Drug Transporter (DT) Information

General Information of DT
DT ID DTD0222
Gene Name SLC25A6
Protein Name Adenine nucleotide translocator 3
Gene ID
293
UniProt ID
P12236
TCDB ID
2.A.29.1.10
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:1OKC_A

Identity:89.226%

Minimized Score:-787.096 kcal/mol

Detail: Structure Info

Synonyms AAC3; ADP/ATP translocase 3; ANT 3; ANT3; ANT3Y; ADP,ATP carrier protein 3; SLC25A6; Solute carrier family 25 member 6; ADP,ATP carrier protein, isoform T2
DT Family Mitochondrial Carrier (MC) Family ;
Function This transporter may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.
Endogenous Substrate(s) Adenine
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Adenine nucleotide translocator 3
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Adenine nucleotide translocator 3
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Adenine nucleotide translocator 3
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Adenine nucleotide translocator 3
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Adenine nucleotide translocator 3
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Adenine nucleotide translocator 3
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Adenine nucleotide translocator 3
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Adenine nucleotide translocator 3
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Adenine nucleotide translocator 3
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Adenine
 Approved Drug Info Dietary shortage 5B7Z [1]
References
1 Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells. Mol Biol Cell. 2007 Nov;18(11):4681-9.

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