Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0222 Transporter Info
Gene Name SLC25A6
Transporter Name Adenine nucleotide translocator 3
Gene ID
293
UniProt ID
P12236
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 SLC25A6 protein results in increased susceptibility to Tretinoin [31]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-4-phenylpyridinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-Methyl-4-phenylpyridinium results in increased expression of SLC25A6 protein [1]

Regulation Mechanism

 Transcription Factor Info

  3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SLC25A6 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC25A6 protein [17]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in increased expression of SLC25A6 protein [18]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in decreased expression of SLC25A6 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  Asbestos, Crocidolite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Asbestos, Crocidolite results in increased expression of SLC25A6 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  azoxystrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 azoxystrobin results in increased expression of SLC25A6 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  Benztropine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benztropine results in increased expression of SLC25A6 protein [7]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in increased expression of SLC25A6 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the expression of SLC25A6 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 bisphenol A results in increased expression of SLC25A6 protein [15]

Regulation Mechanism

 Transcription Factor Info

  bisphenol AF

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol AF results in increased expression of SLC25A6 protein [16]

Regulation Mechanism

 Transcription Factor Info

  bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol B results in increased expression of SLC25A6 protein [16]

Regulation Mechanism

 Transcription Factor Info

  bisphenol F

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol F results in increased expression of SLC25A6 protein [16]

Regulation Mechanism

 Transcription Factor Info

  CD 437

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD 437 results in decreased activity of SLC25A6 protein [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 CD 437 results in decreased expression of SLC25A6 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 chloropicrin results in decreased expression of SLC25A6 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  closantel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 closantel results in decreased activity of SLC25A6 protein [24]

Regulation Mechanism

 Transcription Factor Info

  cobaltous chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 cobaltous chloride results in increased expression of SLC25A6 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  deguelin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 deguelin results in increased expression of SLC25A6 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  dehydroabietylamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 dehydroabietylamine affects the activity of SLC25A6 protein [24]

Regulation Mechanism

 Transcription Factor Info

  deoxynivalenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 deoxynivalenol results in decreased expression of SLC25A6 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  Diuron

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diuron results in decreased expression of SLC25A6 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  Isoniazid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Isoniazid results in decreased expression of SLC25A6 protein [27]

Regulation Mechanism

 Transcription Factor Info

  LDN 193189

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC25A6 protein [17]

Regulation Mechanism

 Transcription Factor Info

  Metribolone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Metribolone promotes the reaction NDRG1 protein binds to SLC25A6 protein [28]

Regulation Mechanism

 Transcription Factor Info

  nickel sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 nickel sulfate results in increased expression of SLC25A6 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  perfluorohexanesulfonic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 perfluorohexanesulfonic acid results in decreased expression of SLC25A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  perfluorooctane sulfonic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 perfluorooctane sulfonic acid results in decreased expression of SLC25A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  perfluorooctanoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 perfluorooctanoic acid results in decreased expression of SLC25A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  pinostrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pinostrobin results in increased expression of SLC25A6 mRNA [30]

Regulation Mechanism

 Transcription Factor Info

  potassium chromate(VI)

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) results in increased expression of SLC25A6 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  Selenium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium results in increased expression of SLC25A6 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC25A6 mRNA [32]

Regulation Mechanism

 Transcription Factor Info

  uranyl acetate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 uranyl acetate affects the expression of SLC25A6 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid results in increased methylation of SLC25A6 gene [33]

Regulation Mechanism

 Transcription Factor Info

  Vanadates

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vanadates results in decreased expression of SLC25A6 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Benzene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzene results in decreased expression of SLC25A6 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

Nanoparticle

  perfluoro-n-nonanoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 perfluoro-n-nonanoic acid results in decreased expression of SLC25A6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Dopamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dopamine increases the expression of SLC25A6 [1]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen inhibits the expression of SLC25A6 [2]

  Temozolomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Temozolomide increases the expression of SLC25A6 [3]

  Ivermectin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ivermectin inhibits the expression of SLC25A6 [4]

  Tretinoin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tretinoin inhibits the expression of SLC25A6 [5]

  Benzatropine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzatropine increases the expression of SLC25A6 [7]

  Clozapine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Clozapine increases the expression of SLC25A6 [7]

Drug Marketed but not Approved by US FDA

  Rotenone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rotenone increases the expression of SLC25A6 [6]

Drug in Phase 3 Trial

  Vitamin E

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vitamin E increases the expression of SLC25A6 [11]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A increases the expression of SLC25A6 [15]

  Bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol B increases the expression of SLC25A6 [16]

Natural Product

  Dietary Carbohydrates

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dietary Carbohydrates inhibits the expression of SLC25A6 [10]

  Selenium nanoparticles

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium nanoparticles increases the expression of SLC25A6 [11]

  Deguelin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Deguelin increases the expression of SLC25A6 [6]

Environmental toxicant

  Bisphenol F

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol F increases the expression of SLC25A6 [16]

Mycotoxins

  Deoxynivalenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Deoxynivalenol inhibits the expression of SLC25A6 [14]

Acute Toxic Substance

  Uranium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Uranium affects the expression of SLC25A6 [9]

  Chloropicrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Chloropicrin inhibits the expression of SLC25A6 [13]

Fungicide

  Azoxystrobin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Azoxystrobin increases the expression of SLC25A6 [6]

Health and Environmental Toxicant

  CD-437

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CD-437 inhibits the expression of SLC25A6 [8]

  1-methyl-4-phenylpyridinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-methyl-4-phenylpyridinium increases the expression of SLC25A6 [1]

  Perfluorooctane sulfonic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Perfluorooctane sulfonic acid inhibits the expression of SLC25A6 [12]
References
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2 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
3 Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
4 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
5 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
6 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615.
7 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144.
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11 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
12 Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes depressed immune functionality in early childhood. J Immunotoxicol. 2016;13(2):173-80.
13 Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
14 Comparison of the toxic mechanism of T-2 toxin and deoxynivalenol on human chondrocytes by microarray and bioinformatics analysis. Toxicol Lett. 2020 Mar 15;321:61-68.
15 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101.
16 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730.
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18 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
19 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
20 DNA methylation profiling of asbestos-treated MeT5A cell line reveals novel pathways implicated in asbestos response. Arch Toxicol. 2018;92(5):1785-1795.
21 Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010;184(1-2):207-11.
22 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
23 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
24 Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast. J Biomol Screen. 2016 Apr;21(4):381-90.
25 Global gene expression profiling in human lung cells exposed to cobalt. BMC Genomics. 2007;8:147.
26 The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles. Front Immunol. 2022;13:925241.
27 Endoplasmic reticulum stress inhibition preserves mitochondrial function and cell survival during the early onset of isoniazid-induced oxidative stress. Chem Biol Interact. 2025;411:111448.
28 Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Mol Cell Proteomics. 2007;6(4):575-88.
29 Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer. Metallomics. 2012 Aug;4(8):784-93.
30 Pinostrobin modulates FOXO3 expression, nuclear localization, and exerts antileukemic effects in AML cells and zebrafish xenografts. Chem Biol Interact. 2023;385:110729.
31 Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid. Exp Cell Res. 2006;312(10):1813-9.
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