Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0222 Transporter Info
Gene Name SLC25A6
Transporter Name Adenine nucleotide translocator 3
Gene ID
293
UniProt ID
P12236

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Breast; Cervix

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Jun (JUN) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Bone marrow; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Uterus; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A6 gene in MCF7 cells [5]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC25A6 gene in MCF7 cells, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 3.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Cervix; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC25A6 gene in . condition, which leads to a affected expression of the drug transporter Adenine nucleotide translocator 3.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        ESR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 Estrogen receptor beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor beta (ESR2) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A6 gene in health condition [7]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A6 gene in health condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 3.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast; Epithelium; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        EGR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 E3 SUMO-protein ligase EGR2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 E3 SUMO-protein ligase EGR2 (EGR2) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Breast; Foreskin; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        TFDP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 Transcription factor Dp-1 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Dp-1 (TFDP1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A6 gene in megakaryocytes condition [8]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC25A6 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Adenine nucleotide translocator 3.

       Transcriptional Phenomenon2

 Direct binding to SLC25A6 gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Umbilical cord blood; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GTF2B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A6 gene [3]

TF Protein Name

 Transcription initiation factor IIB Transcription Factor Info

Tissue

 Cervix; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription initiation factor IIB (GTF2B) can directly bind to the SLC25A6 gene, which in turn affects the expression or function of the drug transporter Adenine nucleotide translocator 3.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-386. (ID:ENSG00000169100)
5 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
6 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
7 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
8 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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