Drug Transporter (DT) Information

General Information of DT
DT ID DTD0200
Gene Name SLC25A38
Protein Name Mitochondrial glycine transporter
Gene ID
54977
UniProt ID
Q96DW6
TCDB ID
2.A.29.5.6
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms Mitochondrial glycine transporter GlyC; SIDBA2; SLC25A38; Solute carrier family 25 member 38
DT Family Mitochondrial Carrier (MC) Family ;
Tissue Specificity Preferentially expressed in erythroid cells.
Function Mitochondrial glycine transporters introduce glycine into mitochondrial matrix. In the first enzymatic step of heme biosynthesis, glycine is condensed with succinyl CoA to produce 5- aminolevulinic acid (ALA) in mitochondrial matrix, which is required during erythropoiesis.
Endogenous Substrate(s) Glycine; 5-Aminolevulinate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Mitochondrial glycine transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Mitochondrial glycine transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Mitochondrial glycine transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Mitochondrial glycine transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Mitochondrial glycine transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Mitochondrial glycine transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Mitochondrial glycine transporter
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Mitochondrial glycine transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Mitochondrial glycine transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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