Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0200 Transporter Info
Gene Name SLC25A38
Transporter Name Mitochondrial glycine transporter
Gene ID
54977
UniProt ID
Q96DW6

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        FOSL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 Fos-related antigen 2 Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 2 (FOSL2) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Embryo; Liver; Lung; Uterus; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A38 gene in melanoma condition [5]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC25A38 gene in melanoma condition, which leads to an increased expression of the drug transporter Mitochondrial glycine transporter.

        MNT 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Max-binding protein MNT Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Max-binding protein MNT (MNT) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        MYC 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC25A38 gene in medulloblastoma condition [6]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A38 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Mitochondrial glycine transporter.

       Transcriptional Phenomenon2

 Repression of SLC25A38 gene in Burkitt lymphoma condition [7]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A38 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Mitochondrial glycine transporter.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Tissue

 Breast; Cervix

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in health condition [8]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A38 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in megakaryocytes condition [9]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC25A38 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        BCL6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A38 gene in health condition [10]

TF Protein Name

 B-cell lymphoma 6 protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC25A38 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial glycine transporter.

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in melanocyte deficiency condition [11]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcriptional repressor protein YY1 (YY1) has been reported to bind to the transcription of SLC25A38 gene in melanocyte deficiency condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        CUX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC25A38 gene in multiple human cancer types condition [12]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC25A38 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Mitochondrial glycine transporter.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in prostate cancer condition [13]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC25A38 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

       Transcriptional Phenomenon2

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 9 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene [14]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLC25A38 gene in . condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in hypoxia condition [15]

TF Protein Name

 ETS domain-containing protein Elk-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC25A38 gene in hypoxia condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        ETS2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Protein C-ets-2 Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-2 (ETS2) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [3]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.2: Heteromeric CCAAT-binding factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFYA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [1]

TF Protein Name

 Nuclear transcription factor Y subunit alpha Transcription Factor Info

Tissue

 Bone marrow; Cervix; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

        NFYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 Nuclear transcription factor Y subunit beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RBPJ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in immortal lymphoblast cell lines (LCLs) condition [16]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC25A38 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC25A38 gene in megakaryocytes condition [9]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC25A38 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial glycine transporter.

TF Superclass8: beta-Sheet binding to DNA

      Class8.1: TATA-binding proteins

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TBP 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC25A38 gene [2]

TF Protein Name

 TATA-box-binding protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 TATA-box-binding protein (TBP) can directly bind to the SLC25A38 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glycine transporter.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-311. (ID:ENSG00000144659)
5 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
7 Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
8 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
10 The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
11 YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8(5):e1002688.
12 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
13 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
14 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
15 The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
16 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.

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