Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0200 Transporter Info
Gene Name	SLC25A38
Transporter Name	Mitochondrial glycine transporter
Gene ID	54977
UniProt ID	Q96DW6

Post-Translational Modification of This DT
Overview ofSLC25A38 Modification Sites with Functional and Structural Information
Sequence	M I Q N S R P S L L Q P Q D V G D T V E T L M L H P V I K A F L C G S I S G T C S T L L F Q P L D L L K T R L Q T L Q P S D H G S R R V G M L A V L L K V V R T E S L L G L W K G M S P S I V R C V P G V G I Y F G T L Y S L K Q Y F L R G H P P T A L E S V M L G V G S R S V A G V C M S P I T V I K T R Y E S G K Y G Y E S I Y A A L R S I Y H S E G H R G L F S G L T A T L L R D A P F S G I Y L M F Y N Q T K N I V P H D Q V D A T L I P I T N F S C G I F A G I L A S L V T Q P A D V I K T H M Q L Y P L K F Q W I G Q A V T L I F K D Y G L R G F F Q G G I P R A L R R T L M A A M A W T V Y E E M M A K M G L K S
PTM type	X-Phosphorylation X-Phosphorylation X: Amino Acid

Phosphorylation
Serine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A38			[1]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	110
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A38 Serine 110 has the potential to affect its expression or activity.
Threonine	3 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[2]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	182
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A38 Threonine 182 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC25A38			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	283
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A38 Threonine 283 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC25A38			[3]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	291
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A38 Threonine 291 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC25A38			[3]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	293
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC25A38 Tyrosine 293 has the potential to affect its expression or activity.

References
1	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
2	15 years of PhosphoSitePlus?: integrating post-translationally modified sites, disease variants and isoforms. Nucleic Acids Res. 2019;47(D1):D433-D441.
3	Sequential enrichment with titania-coated magnetic mesoporous hollow silica microspheres and zirconium arsenate-modified magnetic nanoparticles for the study of phosphoproteome of HL60 cells. J Chromatogr A. 2014 Oct 24;1365:54-60.

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Detail Information of Post-Translational Modifications

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