Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0173 | ||||
| Gene Name | SLC25A15 | ||||
| Protein Name | Mitochondrial ornithine transporter 1 | ||||
| Gene ID | |||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | D13S327; HHH; ORC1; ORNT1; SLC25A15; SP1855; Solute carrier family 25 member 15 | ||||
| DT Family | Mitochondrial Carrier (MC) Family ; | ||||
| Tissue Specificity | Highly expressed in liver, pancreas, testis,lung and small intestine. Lower levels are detected in spleen,kidney, brain and heart. | ||||
| Function | This transporter is ornithine-citrulline antiporter and it connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline. | ||||
| Endogenous Substrate(s) | Ornithine; Citrulline | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Mitochondrial ornithine transporter 1 |
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(β) Cell Distribution Level of Mitochondrial ornithine transporter 1 |
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(γ) Organelle Distribution Level of Mitochondrial ornithine transporter 1 |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Mitochondrial ornithine transporter 1 |
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(γ) Transcriptional Regulation of Mitochondrial ornithine transporter 1 |
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(δ) Epigenetic Regulation of Mitochondrial ornithine transporter 1 |
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(ε) Exogenous Modulation of Mitochondrial ornithine transporter 1 |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Mitochondrial ornithine transporter 1 |
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(β) Disease-specific Protein Abundances of Mitochondrial ornithine transporter 1 |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.