Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0173 Transporter Info | ||||
Gene Name | SLC25A15 | ||||
Transporter Name | Mitochondrial ornithine transporter 1 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Blood; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
CEBPB |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Breast; Cervix; Colon; Embryo; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class1.2: Basic helix-loop-helix factors |
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MAX |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Protein max | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein max (MAX) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
MYC |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in HL60 condition | [5] | ||||
TF Protein Name |
Myc proto-oncogene protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of SLC25A15 gene in HL60 condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon2 |
Repression of SLC25A15 gene in medulloblastoma condition | [6] | ||||
TF Protein Name |
Myc proto-oncogene protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A15 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
TCF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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AR |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [7] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of SLC25A15 gene in . condition, which leads to a affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon2 |
Binding to SLC25A15 gene in prostate cancer condition | [8] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of SLC25A15 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon3 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Tissue |
Cervix; Kidney; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Androgen receptor (AR) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
ESR1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Estrogen receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Estrogen receptor (ESR1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
HNF4A |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in health condition | [9] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC25A15 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class2.3: C2H2 zinc finger factors |
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CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
KLF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
Krueppel-like factor 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 1 (KLF1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
ZNF384 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Zinc finger protein 384 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 384 (ZNF384) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
E2F4 |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in health condition | [10] | ||||
TF Protein Name |
Transcription factor E2F4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC25A15 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
E2F8 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Transcription factor E2F8 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F8 (E2F8) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
FOXP1 |
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Transcriptional Phenomenon1 |
Repression of SLC25A15 gene in embryonic stem cell condition | [11] | ||||
TF Protein Name |
Forkhead box protein P1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC25A15 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class3.5: Tryptophan cluster factors |
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ERG |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
ETS1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Prostate; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
FLI1 |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in megakaryocytes condition | [12] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC25A15 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
GABPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
MYB |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
Transcriptional activator Myb | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional activator Myb (MYB) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
SPI1 |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in acute promyelocytic leukemia condition | [13] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC25A15 gene in acute promyelocytic leukemia condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
SPIB |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Transcription factor Spi-B | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Spi-B (SPIB) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class3.7: ARID domain factors |
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ARID3A |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
AT-rich interactive domain-containing protein 3A | Transcription Factor Info | ||||
Tissue |
Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
KDM5B |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [2] | ||||
TF Protein Name |
Lysine-specific demethylase 5B | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class5.1: MADS box factors |
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MEF2A |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [3] | ||||
TF Protein Name |
Myocyte-specific enhancer factor 2A | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
SRF |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [4] | ||||
TF Protein Name |
Serum response factor | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Serum response factor (SRF) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class6.1: Rel homology region factors |
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EBF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene | [1] | ||||
TF Protein Name |
Transcription factor COE1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor COE1 (EBF1) can directly bind to the SLC25A15 gene, which in turn affects the expression or function of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class6.3: p53 domain factors |
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TP53 |
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Transcriptional Phenomenon1 |
Direct binding to SLC25A15 gene in HFKS condition | [14] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC25A15 gene in HFKS condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Transcriptional Phenomenon2 |
Binding to SLC25A15 gene in health condition | [15] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC25A15 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
Class6.4: Runt domain factors |
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RUNX1 |
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Transcriptional Phenomenon1 |
Binding to SLC25A15 gene in megakaryocytes condition | [12] | ||||
TF Protein Name |
Runt-related transcription factor 1 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC25A15 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Mitochondrial ornithine transporter 1. | |||||
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