Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0143 | ||||
| Gene Name | SLC22A17 | ||||
| Protein Name | Brain-type organic cation transporter | ||||
| Gene ID | |||||
| UniProt ID | |||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | 24p3 receptor; 24p3R; BOCT; BOIT; Lipocalin-2 receptor; NGALR2; NGALR3; Neutrophil gelatinase-associated lipocalin receptor; NgalR; SLC22A17; Solute carrier family 22 member 17; hBOIT | ||||
| DT Family | Major Facilitator Superfamily (MFS) | ||||
| Organic Cation Transporter (OCT) Family | |||||
| Tissue Specificity | Expressed in brain. | ||||
| Function | This transporter plays a key role in iron homeostasis and transport, it is able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. | ||||
| Endogenous Substrate(s) | organic cations | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Brain-type organic cation transporter |
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(β) Cell Distribution Level of Brain-type organic cation transporter |
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(γ) Organelle Distribution Level of Brain-type organic cation transporter |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Brain-type organic cation transporter |
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(γ) Transcriptional Regulation of Brain-type organic cation transporter |
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(δ) Epigenetic Regulation of Brain-type organic cation transporter |
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(ε) Exogenous Modulation of Brain-type organic cation transporter |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Brain-type organic cation transporter |
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(β) Disease-specific Protein Abundances of Brain-type organic cation transporter |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.