General Information of Drug Transporter (DT)
DT ID	DTD0143 Transporter Info
Gene Name	SLC22A17
Protein Name	Brain-type organic cation transporter
Gene ID	51310
UniProt ID	Q8WUG5
Genetic Polymorphisms of DT (GPD)
Genetic Polymorphism	rs4982753
Site of GPD	chr14:23345360 (GRCh38.p12)
GPD Type	SNP
Allele(s) in dbSNP	C>A / C>T
Minor Allele Frequency	T=0.2283/28669 (Global)
Allele T	Click to Show/Hide the Full List of Affected Drugs:           3 Drugs in Total
Anthracyclines And Related Substances	N.A.	Cardiotoxicity	Allele T is associated with decreased risk of Cardiotoxicity when exposed to anthracyclines and related substances in people with Hodgkin Disease or Sarcoma as compared to allele C.		[ 1]
Daunorubicin	N.A.	Cardiotoxicity	Allele T is associated with decreased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele C.		[ 2]
Doxorubicin	N.A.	Cardiotoxicity	Allele T is associated with decreased likelihood of cardiotoxicity when treated with daunorubicin or doxorubicin in children with Neoplasms as compared to allele C.		[ 2]
Allele G	Click to Show/Hide the Full List of Affected Drugs:           1 Drugs in Total
Anthracyclines	N.A.	Cardiotoxicity	Correlated with the anthracycline-induced cardiotoxicity (compare with allele A)		[ 2]
References
1	Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci. Pharmacogenomics J. 2024 Jun 29;24(4):21.
2	Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. Pharmacogenomics. 2015;16(10):1065-76.

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