Drug Transporter (DT) Information

General Information of DT
DT ID DTD0089
Gene Name SLC12A8
Protein Name Cation-chloride cotransporter 9
Gene ID
84561
UniProt ID
A0AV02
TCDB ID
2.A.30.1.7
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:6PZT_A

Identity:33.493%

Minimized Score:-801.025 kcal/mol

Detail: Structure Info

Synonyms Solute carrier family 12 member 8; SLC12A8; CCC9
DT Family Cation-Chloride Cotransporter (CCC) Family ;
Tissue Specificity Ubiquitous with very low level in normal skin.
Function This cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation.
Endogenous Substrate(s) Nicotinamide mononucleotide
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Cation-chloride cotransporter 9
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Cation-chloride cotransporter 9
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Cation-chloride cotransporter 9
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(β) Post-translational Modification of Cation-chloride cotransporter 9
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Cation-chloride cotransporter 9
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Cation-chloride cotransporter 9
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Cation-chloride cotransporter 9
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Cation-chloride cotransporter 9
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Cation-chloride cotransporter 9
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           1 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Nicotinamide mononucleotide
 Preclinical Drug Info Dietary shortage 5B7Z [1]
References
1 Slc12a8 is a nicotinamide mononucleotide transporter. Nature Metabolismvolume 1, pages4757 (2019).

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.