Detail Information of Genetic Polymorphisms
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0089 Transporter Info | ||||
| Gene Name | SLC12A8 | ||||
| Protein Name | Cation-chloride cotransporter 9 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Genetic Polymorphisms of DT (GPD) | |||||
| Genetic Polymorphism | rs651630 | ||||
| Site of GPD | chr3:125092470 (GRCh38.p12) | ||||
| GPD Type | SNP | ||||
| Allele(s) in dbSNP | G>A | ||||
| Minor Allele Frequency | A=0.3916/1961 (Global) | ||||
| Genotype AA | Click to Show/Hide the Full List of Affected Drugs: 2 Drugs in Total | ||||
| Tumor Necrosis Factor Alpha (tnf-alpha) Inhibitors | N.A. | Psoriasis | Genotype AA is associated with decreased risk of Psoriasis when treated with Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Psoriasis as compared to genotypes AG + GG. | [ 1] | |
| Tumor necrosis factor alpha (Tnf-Alpha) inhibitors | N.A. | Psoriasis | Correlated with the decreased psoriasis risk in patients (compare with genotypes AG + GG) | [ 1] | |
| Genotype AG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Tumor Necrosis Factor Alpha (tnf-alpha) Inhibitors | N.A. | Psoriasis | Patients with the AG genotype and psoriasis may have an increased risk for paradoxical psoriasiform reactions when treated with TNF-inhibitors as compared to patients with the AA genotype. Other genetic and clinical factors may also influence risk for paradoxical psoriasiform reactions. | [ 1] | |
| Genotype GG | Click to Show/Hide the Full List of Affected Drugs: 1 Drugs in Total | ||||
| Tumor Necrosis Factor Alpha (tnf-alpha) Inhibitors | N.A. | Psoriasis | Patients with the GG genotype and psoriasis may have an increased risk for paradoxical psoriasiform reactions when treated with TNF-inhibitors as compared to patients with the AA genotype. Other genetic and clinical factors may also influence risk for paradoxical psoriasiform reactions. | [ 1] | |
| References | |||||
| 1 | Paradoxical psoriasiform reactions to anti-TNF drugs are associated with genetic polymorphisms in patients with psoriasis. Pharmacogenomics J. 2016 Aug;16(4):336-40. | ||||
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