Modelled DT Structure
Method: multi-sequence alignment based machine learning
Detail: Structure Info
Drug Transporter (DT) Information
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| General Information of DT | |||||
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| DT ID | DTD0078 | ||||
| Gene Name | SLC10A6 | ||||
| Protein Name | Sodium-dependent organic anion transporter | ||||
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| 3D Structure |
Modelled DT Structure Method: multi-sequence alignment based machine learning Detail: Structure Info |
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| Synonyms | SLC10A6; SOAT; Solute carrier family 10 member 6 | ||||
| DT Family | Bile Acid:Na(+) Symporter (BASS) Family ; | ||||
| Tissue Specificity | Highly expressed in testis, placenta andpancreas. Moderately expressed in heart, lung and mammary gland.Weakly expressed in brain, colon, kidney, liver, ovary, prostate,small intestine, spleen and thymus. | ||||
| Function | This transporter transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner. | ||||
| Endogenous Substrate(s) | Organic anions; Na+; Dehydroepiandrosterone sulfate; Estrone-3-sulfate; Pregnenolone sulfate; Sulfoconjugated taurolithocholate | ||||
| Variability Data of This Drug Transporter (DT) | |||||
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Regulatory Variability Data of This DT (VARIDT 4.0) |
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(α) Tissue Distribution Level of Sodium-dependent organic anion transporter |
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(β) Cell Distribution Level of Sodium-dependent organic anion transporter |
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(γ) Organelle Distribution Level of Sodium-dependent organic anion transporter |
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Regulatory Variability Data of This DT |
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(β) Post-translational Modification of Sodium-dependent organic anion transporter |
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(γ) Transcriptional Regulation of Sodium-dependent organic anion transporter |
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(δ) Epigenetic Regulation of Sodium-dependent organic anion transporter |
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(ε) Exogenous Modulation of Sodium-dependent organic anion transporter |
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General Variability Data of This DT |
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(α) Genetic Polymorphisms of Sodium-dependent organic anion transporter |
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(β) Disease-specific Protein Abundances of Sodium-dependent organic anion transporter |
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(γ) Species- and Tissue-specific DT Abundances |
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If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.