Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0078 Transporter Info
Gene Name	SLC10A6
Transporter Name	Sodium-dependent organic anion transporter
Gene ID	345274
UniProt ID	Q3KNW5

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC10A6 exon		[4]
Regulation Mechanism			Transcription Factor Info
Chemical Compound
Arsenicals	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenicals results in increased expression of SLC10A6 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC10A6 promoter		[5]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC10A6 5' UTR		[5]
Regulation Mechanism			Transcription Factor Info
betulin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	betulin affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	betulin inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
Betulinic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Betulinic Acid affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Betulinic Acid inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC10A6 gene		[7]
Regulation Mechanism			Transcription Factor Info
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
daidzein	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction SLC10A6 protein results in increased transport of estrone sulfate		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	daidzein metabolite inhibits the reaction SLC10A6 protein results in increased transport of estrone sulfate		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	estrone sulfate inhibits the reaction SLC10A6 protein results in increased transport of daidzein metabolite		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC10A6 protein results in increased transport of daidzein metabolite		[8]
Regulation Mechanism			Transcription Factor Info
Dehydroepiandrosterone Sulfate	15 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	betulin affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Betulinic Acid inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Dehydroepiandrosterone Sulfate affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Dehydroepiandrosterone Sulfate inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Erythrosine inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Irbesartan inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Losartan inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	lupenone affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	Sulfobromophthalein inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	Taurocholic Acid affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	Taurolithocholic Acid inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Troglitazone inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
Erythrosine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Erythrosine inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Erythrosine inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
estrone sulfate	8 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction SLC10A6 protein results in increased transport of estrone sulfate		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	daidzein metabolite inhibits the reaction SLC10A6 protein results in increased transport of estrone sulfate		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	estrone sulfate inhibits the reaction SLC10A6 protein results in increased transport of daidzein metabolite		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC10A6 protein results in increased susceptibility to estrone sulfate		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC10A6 protein results in increased transport of estrone sulfate		[8]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	SLC10A6 protein results in increased uptake of estrone sulfate		[9]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of estrone sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Sodium promotes the reaction SLC10A6 protein results in increased uptake of estrone sulfate		[9]
Regulation Mechanism			Transcription Factor Info
Irbesartan	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Irbesartan inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
Losartan	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Losartan inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
lupenone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lupenone affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	lupenone affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
methylarsine oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylarsine oxide results in increased expression of SLC10A6 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
pregnenolone sulfate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC10A6 protein results in increased uptake of pregnenolone sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of pregnenolone sulfate		[6]
Regulation Mechanism			Transcription Factor Info
Sodium	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of estrone sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of pregnenolone sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Sodium promotes the reaction SLC10A6 protein results in increased uptake of estrone sulfate		[9]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased expression of SLC10A6 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
Sulfobromophthalein	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulfobromophthalein inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Sulfobromophthalein inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
Taurocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Taurocholic Acid affects the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Taurocholic Acid affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
Taurolithocholic Acid	15 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Betulinic Acid affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	betulin inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Dehydroepiandrosterone Sulfate inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Erythrosine inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Irbesartan inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Losartan inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	lupenone affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Sodium deficiency inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	Sulfobromophthalein inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	Taurocholic Acid affects the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	Taurolithocholic Acid inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	Taurolithocholic Acid inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	Troglitazone inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
theaflavin-3,3'-digallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	theaflavin-3,3'-digallate affects the expression of SLC10A6 mRNA		[11]
Regulation Mechanism			Transcription Factor Info
Troglitazone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the reaction SLC10A6 protein results in increased uptake of Dehydroepiandrosterone Sulfate		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Troglitazone inhibits the reaction SLC10A6 protein results in increased uptake of Taurolithocholic Acid		[6]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic increases the expression of SLC10A6		[1]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC10A6		[3]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC10A6		[2]

References
1	Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
2	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
3	Dynamic alteration in miRNA and mRNA expression profiles at different stages of chronic arsenic exposure-induced carcinogenesis in a human cell culture model of skin cancer. Arch Toxicol. 2021 Jul;95(7):2351-2365.
4	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
5	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
6	Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT. Front Mol Biosci. 2021;8:689757.
7	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
8	Transport of the soy isoflavone daidzein and its conjugative metabolites by the carriers SOAT, NTCP, OAT4, and OATP2B1. Arch Toxicol. 2015;89(12):2253-63.
9	Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6). Front Pharmacol. 2018;9:941.
10	Inorganic arsenic and its methylated metabolites as endocrine disruptors in the placenta: Mechanisms underpinning glucocorticoid receptor (GR) pathway perturbations. Toxicol Appl Pharmacol. 2020;409:115305.
11	Theaflavin 3, 3'-Digallate Delays Ovarian Aging by Improving Oocyte Quality and Regulating Granulosa Cell Function. Oxid Med Cell Longev. 2021;2021:7064179.

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Detail Information of Exogenous Modulation

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