Drug Transporter (DT) Information

General Information of DT
DT ID DTD0020
Gene Name SLC10A2
Protein Name Apical sodium-dependent bile acid transporter
Gene ID
6555
UniProt ID
Q12908
TCDB ID
2.A.28.1.2
3D Structure

Modelled DT Structure

Method:homology modeling

Template PDB:3ZUY_A

Identity:33.333%

Minimized Score:-495.929 kcal/mol

Detail: Structure Info

Synonyms ASBT; IBAT; ISBT; Ileal Na(+)/bile acid cotransporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; NTCP2; Na(+)-dependent ileal bile acid transporter; PBAM; SLC10A2; Sodium/taurocholate cotransporting polypeptide, ileal; Solute carrier family 10 member 2
DT Family Bile Acid:Na(+) Symporter (BASS) Family ;
Function This transporter plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine.
Endogenous Substrate(s) Bile acids; Bile conjugates; Cholate; Glycochenodeoxycholate
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Apical sodium-dependent bile acid transporter
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Apical sodium-dependent bile acid transporter
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Apical sodium-dependent bile acid transporter
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Apical sodium-dependent bile acid transporter
Microbiota Influence (MBI)

(β) Post-translational Modification of Apical sodium-dependent bile acid transporter
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Apical sodium-dependent bile acid transporter
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Apical sodium-dependent bile acid transporter
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Apical sodium-dependent bile acid transporter
Exogenous Modulation (EGM)

Structural Variability Data of This DT

(β) Inter-species Structural Differences
Inter-species Structural Differences (ISD)

General Variability Data of This DT

(α) Genetic Polymorphisms of Apical sodium-dependent bile acid transporter
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Apical sodium-dependent bile acid transporter
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)
Molecular Transporting Profile of This DT

Full List of Drug(s) Transported by This DT

 Approved Drug

 Click to Show/Hide the Full List of Drug:           2 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Cholic acid
 Approved Drug Info Synthesis disorders 5C52.10 [1]
Deoxycholic acid
 Approved Drug Info Fat below the chin 5B80 [2]

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:           3 Drugs in Total
Drug Name Highest Status Detail Indication ICD 11 Ref
Glycodeoxycholic acid
 Preclinical Drug Info Asthma CA23 [1]
Sodium taurocholate
 Preclinical Drug Info Type 2 diabetes 5A11 [3]
Taurocholic acid
 Terminated Drug Info Type 2 diabetes 5A11 [3]

Endogenous Metabolites (EMs) Handled by This DT

 Endogenous Metabolites (EMs)

 Click to Show/Hide the Full List of EMs:           1 EMs in Total
EM Name PubChem CID Detail Experimental Material Ref
Bile acid unspecific N.A. EM Info Identified using actively drinking cirrhotic patients [4]

Drug-DT Affinity Assessed by Cell Line

 Withdrawn, Discontinued or Preclinical Drug

 Click to Show/Hide the Full List of Drug:         59 Drugs in Total
Drug Name Highest Status Detail Cell Line Affinity Ref
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Sodium taurocholate Preclinical Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Sodium taurocholate Preclinical Drug Info Monkey kidney fibroblast-like cell (COS)7-ASBT Km =16 microM [6]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
Taurocholic acid Terminated Drug Info Human embryonic kidney cells (HEK293)-ASBT Km =9.4 microM [3]
Taurocholic acid Terminated Drug Info Monkey kidney fibroblast-like cell (COS)1-ASBT Km =13.3 microM [5]
References
1 Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1):G157-69.
2 Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery. Biomaterials. 2018 Jan;151:13-23.
3 Identification of a region of the ileal-type sodium/bile acid cotransporter interacting with a competitive bile acid transport inhibitor. Biochemistry. 2002 Dec 17;41(50):14916-24.
4 Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis. Alcohol Clin Exp Res. 2017 Nov;41(11):1857-1865.
5 Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69.
6 Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2001 Dec;21(12):2039-45.

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