Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0020 Transporter Info
Gene Name SLC10A2
Transporter Name Apical sodium-dependent bile acid transporter
Gene ID
6555
UniProt ID
Q12908

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC10A2 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        FOS 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC10A2 gene in Crohn's ileitis condition [2]

TF Protein Name

 Protein c-Fos Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Protein c-Fos (FOS) has been reported to repress the transcription of SLC10A2 gene in Crohn's ileitis condition, which leads to a decreased expression of the drug transporter Apical sodium-dependent bile acid transporter.

       Transcriptional Phenomenon2

 Repression of SLC10A2 gene in crohn's ileitis condition [3]

TF Protein Name

 Protein c-Fos Transcription Factor Info

Studied Phenotype

 Crohn's ileitis [ICD11: DD70.1]

Tissue

 Ileum

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Protein c-Fos (FOS) has been reported to repress the transcription of SLC10A2 gene in crohn's ileitis condition, which leads to a decreased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in crohn's ileitis condition [3]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 Crohn's ileitis [ICD11: DD70.1]

Tissue

 Ileum

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Transcription factor Jun (JUN) has been reported to activate the transcription of SLC10A2 gene in crohn's ileitis condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC10A2 gene [4]

TF Protein Name

 Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC10A2 gene, which in turn affects the expression or function of the drug transporter Apical sodium-dependent bile acid transporter.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in prostate cancer condition [5]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC10A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

        NR1H4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC10A2 gene in health condition [6]

TF Protein Name

 Bile acid receptor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Colon

Related DT Changes

 Down regulating

Experimental Material

 New Zealand White rabbits

Detailed Description

 Bile acid receptor (NR1H4) has been reported to repress the transcription of SLC10A2 gene in health condition, which leads to a decreased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        NR3C1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in crohn's ileitis condition [7]

TF Protein Name

 Glucocorticoid receptor Transcription Factor Info

Studied Phenotype

 Crohn's ileitis [ICD11: DD70.1]

Tissue

 Ileum

Related DT Changes

 Up regulating

Experimental Material

 human Crohn disease ileal cell isolates

Detailed Description

 Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of SLC10A2 gene in crohn's ileitis condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        NR5A2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in colon cancer condition [8]

TF Protein Name

 Nuclear receptor subfamily 5 group A member 2 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6J mice

Detailed Description

 Nuclear receptor subfamily 5 group A member 2 (NR5A2) has been reported to activate the transcription of SLC10A2 gene in colon cancer condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

       Transcriptional Phenomenon2

 Activation of SLC10A2 gene in health condition [6]

TF Protein Name

 Nuclear receptor subfamily 5 group A member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 New Zealand White rabbits

Detailed Description

 Nuclear receptor subfamily 5 group A member 2 (NR5A2) has been reported to activate the transcription of SLC10A2 gene in health condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        PPARD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC10A2 gene in myofibroblasts condition [9]

TF Protein Name

 Peroxisome proliferator-activated receptor delta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC10A2 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Apical sodium-dependent bile acid transporter.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in THP-1 human monocytic leukemia cells condition [10]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC10A2 gene in THP-1 human monocytic leukemia cells condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC10A2 gene in health condition [11]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Related DT Changes

 Down regulating

Detailed Description

 Transcription factor GATA-4 (GATA4), influenced by the host unspecified microbiota, has been reported to repress the transcription of SLC10A2 gene in health condition, which leads to a decreased expression of the drug transporter Apical sodium-dependent bile acid transporter.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in podocyte condition [12]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC10A2 gene in podocyte condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in HESC condition [13]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC10A2 gene in HESC condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in HESC condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC10A2 gene in HESC condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in stress response condition [14]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC10A2 gene in stress response condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC10A2 gene in health condition [15]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC10A2 gene in health condition, which leads to an affected expression of the drug transporter Apical sodium-dependent bile acid transporter.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in prostate cancer condition [16]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC10A2 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC10A2 gene in human embryonic stem cells (hESCs) condition [17]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC10A2 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Apical sodium-dependent bile acid transporter.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology. 2002;123(6):2005-16.
3 c-Fos is a critical mediator of inflammatory-mediated repression of the apical sodium-dependent bile acid transporter. Gastroenterology. 2006 Aug;131(2):554-67.
4 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
5 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
6 FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G60-6.
7 Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut. 2004 Jan;53(1):78-84.
8 Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter. J Biol Chem. 2003 May 30;278(22):19909-16.
9 Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
10 Patterns of genome-wide VDR locations. PLoS One. 2014;9(4):e96105.
11 Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4. J Hepatol. 2015 Sep;63(3):697-704.
12 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
13 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
14 Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
15 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
16 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
17 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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