Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0020 Transporter Info
Gene Name	SLC10A2
Transporter Name	Apical sodium-dependent bile acid transporter
Gene ID	6555
UniProt ID	Q12908

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC10A2 exon			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC10A2 promoter			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chenodeoxycholic Acid inhibits the reaction SLC10A2 protein results in increased transport of Taurocholic Acid			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Erythrosine inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC10A2 protein results in increased transport of Taurocholic Acid			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Sulfobromophthalein inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Taurocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Taurocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Taurolithocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Troglitazone inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC10A2 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
betulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	betulin affects the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Betulinic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Betulinic Acid affects the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic Acid inhibits the reaction SLC10A2 protein results in increased transport of Taurocholic Acid			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC10A2 protein results in increased uptake of Chenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Chenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Cholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Cholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Cholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
cholylsarcosine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of cholylsarcosine			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of cholylsarcosine			[19]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Deoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Deoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
deoxynivalenol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol results in decreased expression of SLC10A2 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	GW 4064 inhibits the reaction deoxynivalenol results in decreased expression of SLC10A2 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SB 203580 inhibits the reaction deoxynivalenol results in decreased expression of SLC10A2 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
Erythrosine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythrosine inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Erythrosine inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Glycochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Glycocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
glycoursodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of glycoursodeoxycholic acid			[19]
Regulation Mechanism				Transcription Factor Info
GW 4064	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 4064 inhibits the reaction deoxynivalenol results in decreased expression of SLC10A2 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
Indocyanine Green	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Indocyanine Green			[22]
Regulation Mechanism				Transcription Factor Info
lactacystin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lactacystin inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
LDN 57444	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 57444 inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased transport of perfluorooctane sulfonic acid			[23]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid affects the methylation of SLC10A2 gene			[24]
Regulation Mechanism				Transcription Factor Info
SB 203580	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SB 203580 inhibits the reaction deoxynivalenol results in decreased expression of SLC10A2 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
Sodium	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Chenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Cholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of cholylsarcosine			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Deoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Glycodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of glycoursodeoxycholic acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of ursodoxicoltaurine			[19]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfobromophthalein inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sulfobromophthalein inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Taurochenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Taurochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurochenodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Taurodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of Taurodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurodeoxycholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Taurolithocholic Acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	betulin affects the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Betulinic Acid affects the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Erythrosine inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Sulfobromophthalein inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Taurocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Taurolithocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Taurolithocholic Acid inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Troglitazone inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
Troglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the reaction SLC10A2 protein results in increased uptake of Taurocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Troglitazone inhibits the reaction SLC10A2 protein results in increased uptake of Taurolithocholic Acid			[19]
Regulation Mechanism				Transcription Factor Info
ursodoxicoltaurine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 protein results in increased uptake of ursodoxicoltaurine			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium deficiency inhibits the reaction SLC10A2 protein results in increased uptake of ursodoxicoltaurine			[19]
Regulation Mechanism				Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC10A2 gene SNP results in increased susceptibility to Vincristine			[25]
Regulation Mechanism				Transcription Factor Info
Natural Product
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	lactacystin inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	LDN 57444 inhibits the reaction Resveratrol results in decreased expression of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Resveratrol results in decreased expression of and results in decreased activity of SLC10A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Chenodeoxycholic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid inhibits the transportation of Sodium taurocholate by SLC10A2 (Ki = 75 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-ASBT
DT Modulation2	Chenodiol inhibits the transportation of Sodium taurocholate by SLC10A2 (Ki = 3.3 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-ASBT
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Sodium taurocholate by SLC10A2 (Ki = 24 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC10A2			[2]
Secretin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Secretin induces the activity of SLC10A2			[3]
Budesonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide induces the activity of SLC10A2			[4]
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone induces the activity of SLC10A2			[4]
Ciprofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciprofibrate induces the activity of SLC10A2			[5]
Irbesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the activity of SLC10A2			[6]
Drug in Phase 3 Trial
Resveratrol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the expression of SLC10A2			[8]
Elobixibat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elobixibat inhibits the activity of SLC10A2			[12]
Drug in Phase 2 Trial
LUM001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LUM001 inhibits the activity of SLC10A2			[10]
GSK2330672	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK2330672 modulates the activity of SLC10A2			[11]
264W94	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	264W94 modulates the activity of SLC10A2			[13]
S-8921	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-8921 inhibits the activity of SLC10A2			[14]
Colestyramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colestyramine induces the activity of SLC10A2			[16]
Drug in Phase 1/2 Trial
Taurocholic Acid	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurocholic acid modulates the activity of SLC10A2			[1]
Drug in Phase 1 Trial
GSK1614235 + GSK2330672	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK1614235 + GSK2330672 modulates the activity of SLC10A2			[15]
Investigative Drug
Taurochenodeoxycholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurochenodeoxycholate inhibits the transportation of Sodium taurocholate by SLC10A2 (Ki = 6.1 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-ASBT
Tauroursodeoxycholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tauroursodeoxycholate inhibits the transportation of Sodium taurocholate by SLC10A2 (Ki = 28 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)1-ASBT
Mycotoxins
Deoxynivalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxynivalenol inhibits the expression of SLC10A2			[9]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC10A2			[7]

References
1	Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69.
2	Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
3	Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats. Hepatology. 2005 May;41(5):1037-45.
4	Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor. Gut. 2004 Jan;53(1):78-84.
5	Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J Biol Chem. 2002 Aug 23;277(34):30559-66.
6	Structure-activity relationship for FDA approved drugs as inhibitors of the human sodium taurocholate cotransporting polypeptide (NTCP). Mol Pharm. 2013 Mar 4;10(3):1008-19.
7	Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
8	Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2). Biochem J. 2014 Apr 15;459(2):301-12.
9	Exposure to the mycotoxin deoxynivalenol reduces the transport of conjugated bile acids by intestinal Caco-2 cells. Arch Toxicol. 2022 May;96(5):1473-1482.
10	Current research on the treatment of primary sclerosing cholangitis. Intractable Rare Dis Res. 2015 Feb; 4(1): 1-6.
11	Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes. J Med Chem. 2013 Jun 27;56(12):5094-114.
12	Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013 Feb;22(2):277-84.
13	Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes. Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E68-76.
14	Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11.
15	Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 960).
16	Coordinate regulation of bile acid biosynthetic and recovery pathways. Biochem Biophys Res Commun. 1996 Aug 5;225(1):128-33.
17	Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes. FEBS Open Bio. 2023;13(7):1320-1332.
18	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
19	Substrate Specificities and Inhibition Pattern of the Solute Carrier Family 10 Members NTCP, ASBT and SOAT. Front Mol Biosci. 2021;8:689757.
20	Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
21	Ribotoxin deoxynivalenol induces taurocholic acid malabsorption in an in vitro human intestinal model. Toxicol Lett. 2023;383:54-63.
22	Apical Sodium-Dependent Bile Acid Cotransporter, A Novel Transporter of Indocyanine Green, and Its Application in Drug Screening. Int J Mol Sci. 2020;21(6).
23	Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats. Toxicol Sci. 2015;146(2):363-73.
24	Gestational Perfluoroalkyl Substance Exposure and DNA Methylation at Birth and 12 Years of Age: A Longitudinal Epigenome-Wide Association Study. Environ Health Perspect. 2022;130(3):37005.
25	Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. J Clin Oncol. 2011;29(7):797-804.

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Detail Information of Exogenous Modulation

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