Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0547 Transporter Info
Gene Name	KCNK4
Transporter Name	Potassium channel subfamily K member 4
Gene ID	50801
UniProt ID	Q9NYG8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Breast; Cervix; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Colon; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 12 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ASCL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Achaete-scute homolog 2		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 2 (ASCL2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Max-binding protein MNT		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-binding protein MNT (MNT) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Tissue	Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 21 (TCF21) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Embryo; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Tissue	Intestine; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
HNF4G		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 4-gamma		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 16 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Tonsil
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	B-cell lymphoma 6 protein (BCL6) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
CTCFL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Transcriptional repressor CTCFL		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCFL (CTCFL) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
EGR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNK4 gene in erythroleukemia condition			[5]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of KCNK4 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Potassium channel subfamily K member 4.
Transcriptional Phenomenon2	Direct binding to KCNK4 gene			[4]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Colon; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ZBTB7B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7B		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7B (ZBTB7B) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ZNF143		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Zinc finger protein 143		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 143 (ZNF143) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
HOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Homeobox protein Hox-A1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Hox-A1 (HOXA1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
HOXA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Homeobox protein Hox-A6		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Hox-A6 (HOXA6) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of KCNK4 gene in embryonic stem cell condition			[6]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of KCNK4 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Potassium channel subfamily K member 4.
Transcriptional Phenomenon2	Direct binding to KCNK4 gene			[3]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
RFX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	DNA-binding protein RFX2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	DNA-binding protein RFX2 (RFX2) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class3.6: TEA domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TEAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Transcriptional enhancer factor TEF-3		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional enhancer factor TEF-3 (TEAD4) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[3]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[4]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Blood; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNK4 gene in health condition			[7]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of KCNK4 gene in health condition, which leads to an affected expression of the drug transporter Potassium channel subfamily K member 4.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
TF Superclass10: Yet undefined DNA-binding domains
Class10: Uncharacterized		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[1]
TF Protein Name	Nuclear respiratory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear respiratory factor 1 (NRF1) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.
Class10.5: GTF2I domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2I		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNK4 gene			[2]
TF Protein Name	General transcription factor II-I		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	General transcription factor II-I (GTF2I) can directly bind to the KCNK4 gene, which in turn affects the expression or function of the drug transporter Potassium channel subfamily K member 4.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-421. (ID:ENSG00000182450)
5	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
7	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.

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