Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0543 Transporter Info
Gene Name	KCNN1
Transporter Name	Small conductance calcium-activated potassium channel protein 1
Gene ID	3780
UniProt ID	Q92952

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Bone marrow; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of KCNN1 gene in health condition			[4]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of KCNN1 gene in health condition, which leads to an increased expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
MITF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of KCNN1 gene in melanoma condition			[6]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of KCNN1 gene in melanoma condition, which leads to an increased expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Kidney; Liver; Lung; Skin; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc proto-oncogene protein (MYC) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TFAP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Transcription factor AP-4		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-4 (TFAP4) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in MCF7 cells			[7]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of KCNN1 gene in MCF7 cells, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
CTCFL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Transcriptional repressor CTCFL		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCFL (CTCFL) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in erythroleukemia condition			[8]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of KCNN1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Colon; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ZKSCAN1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Zinc finger protein with KRAB and SCAN domains 1		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein with KRAB and SCAN domains 1 (ZKSCAN1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ZNF143		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Zinc finger protein 143		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 143 (ZNF143) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene			[9]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of KCNN1 gene in . condition, which leads to a affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Transcriptional Phenomenon2	Direct binding to KCNN1 gene			[2]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ELK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in health condition			[10]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of KCNN1 gene in health condition, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
SPI1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in K562 cells			[11]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of KCNN1 gene in K562 cells, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Transcriptional Phenomenon2	Binding to KCNN1 gene in HL60 condition			[9]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of KCNN1 gene in HL60 condition, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Transcriptional Phenomenon3	Direct binding to KCNN1 gene			[3]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
NFYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Nuclear transcription factor Y subunit beta		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit beta (NFYB) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[3]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Embryo; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
RBPJ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in immortal lymphoblast cell lines condition			[12]
TF Protein Name	Recombining binding protein suppressor of hairless		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of KCNN1 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[1]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Tissue	Blood; Breast; Cervix; Lung; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor p65 (RELA) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[5]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to KCNN1 gene in megakaryocytes condition			[13]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of KCNN1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Small conductance calcium-activated potassium channel protein 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to KCNN1 gene			[2]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the KCNN1 gene, which in turn affects the expression or function of the drug transporter Small conductance calcium-activated potassium channel protein 1.

References
1	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-202. (ID:ENSG00000105642)
4	Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha. Nucleic Acids Res. 2012;40(15):7416-29.
5	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
6	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
7	A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
8	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
9	Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
10	ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
11	Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
12	Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
13	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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