Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0491 Transporter Info | ||||
Gene Name | SLC9A7 | ||||
Transporter Name | Sodium/hydrogen exchanger 7 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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BATF |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
Basic leucine zipper transcriptional factor ATF-like | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
CEBPB |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Bone | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Blood; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class1.2: Basic helix-loop-helix factors |
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AHR |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in breast cancer condition | [4] | ||||
TF Protein Name |
Aryl hydrocarbon receptor | Transcription Factor Info | ||||
Affected Drug/Substrate |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
ARNT |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in breast cancer condition | [4] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Affected Drug/Substrate |
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
MYOD1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
TCF12 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
Transcription factor 12 | Transcription Factor Info | ||||
Tissue |
Blood; Brain; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 12 (TCF12) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
TCF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2A |
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Transcriptional Phenomenon1 |
Binding to SLC9A7 gene in MCF7 cells | [6] | ||||
TF Protein Name |
Transcription factor AP-2-alpha | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC9A7 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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AR |
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Transcriptional Phenomenon1 |
Binding to SLC9A7 gene in prostate cancer condition | [7] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of SLC9A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
NR2F2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
VDR |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in multiple sclerosis condition | [8] | ||||
TF Protein Name |
Vitamin D3 receptor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC9A7 gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class2.3: C2H2 zinc finger factors |
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CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Cervix; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
WT1 |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in podocyte condition | [9] | ||||
TF Protein Name |
Wilms tumor protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Wilms tumor protein (WT1) has been reported to activate the transcription of SLC9A7 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class3.1: Homeo domain factors |
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PBX1 |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in ovarian cancer condition | [10] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC9A7 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Blood; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
FOXM1 |
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Transcriptional Phenomenon1 |
Activation of SLC9A7 gene in breast cancer condition | [11] | ||||
TF Protein Name |
Forkhead box protein M1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
FOXP1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
Forkhead box protein P1 | Transcription Factor Info | ||||
Tissue |
Embryo; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein P1 (FOXP1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class3.5: Tryptophan cluster factors |
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ERG |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
FLI1 |
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Transcriptional Phenomenon1 |
Binding to SLC9A7 gene in megakaryocytes condition | [12] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC9A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
SPI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [1] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
SPIB |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
Transcription factor Spi-B | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Spi-B (SPIB) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class5.1: MADS box factors |
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MEF2A |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [2] | ||||
TF Protein Name |
Myocyte-specific enhancer factor 2A | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class6.1: Rel homology region factors |
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EBF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [3] | ||||
TF Protein Name |
Transcription factor COE1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor COE1 (EBF1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class6.2: STAT domain factors |
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STAT3 |
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Transcriptional Phenomenon1 |
Binding to SLC9A7 gene in glioblastoma multiforme condition | [13] | ||||
TF Protein Name |
Signal transducer and activator of transcription 3 | Transcription Factor Info | ||||
Affected Drug/Substrate |
Temozolomide | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC9A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class6.3: p53 domain factors |
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TP63 |
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Transcriptional Phenomenon1 |
Binding to SLC9A7 gene in epithelial to mesenchymal transition condition | [14] | ||||
TF Protein Name |
Tumor protein 63 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC9A7 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7. | |||||
Class6.7: Grainyhead domain factors |
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GRHL2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
Grainyhead-like protein 2 homolog | Transcription Factor Info | ||||
Tissue |
Bronchus; Ovary | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
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NFIC |
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Transcriptional Phenomenon1 |
Direct binding to SLC9A7 gene | [5] | ||||
TF Protein Name |
Nuclear factor 1 C-type | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear factor 1 C-type (NFIC) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7. | |||||
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