General Information of Drug Transporter (DT)
DT ID DTD0491 Transporter Info
Gene Name SLC9A7
Transporter Name Sodium/hydrogen exchanger 7
Gene ID
84679
UniProt ID
Q96T83

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        BATF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

Basic leucine zipper transcriptional factor ATF-like Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

Bone

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [3]

TF Protein Name

Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

Blood; Liver

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in breast cancer condition [4]

TF Protein Name

Aryl hydrocarbon receptor Transcription Factor Info

Affected Drug/Substrate

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

        ARNT 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in breast cancer condition [4]

TF Protein Name

Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Affected Drug/Substrate

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

       Transcriptional Phenomenon2

Direct binding to SLC9A7 gene [5]

TF Protein Name

Aryl hydrocarbon receptor nuclear translocator Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [5]

TF Protein Name

Myoblast determination protein 1 Transcription Factor Info

Tissue

Myotube

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myoblast determination protein 1 (MYOD1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

Transcription factor 12 Transcription Factor Info

Tissue

Blood; Brain; Embryo

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor 12 (TCF12) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [3]

TF Protein Name

Transcription factor E2-alpha Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2-alpha (TCF3) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        TFAP2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC9A7 gene in MCF7 cells [6]

TF Protein Name

Transcription factor AP-2-alpha Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Transcription factor AP-2-alpha (TFAP2A) has been reported to bind to the transcription of SLC9A7 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7.

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [3]

TF Protein Name

Transcription factor AP-2 gamma Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC9A7 gene in prostate cancer condition [7]

TF Protein Name

Androgen receptor Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Androgen receptor (AR) has been reported to bind to the transcription of SLC9A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [5]

TF Protein Name

COUP transcription factor 2 Transcription Factor Info

Tissue

Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

COUP transcription factor 2 (NR2F2) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in multiple sclerosis condition [8]

TF Protein Name

Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLC9A7 gene in multiple sclerosis condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

Erythroid transcription factor Transcription Factor Info

Tissue

Blood; Bone marrow

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Erythroid transcription factor (GATA1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

Transcriptional repressor CTCF Transcription Factor Info

Tissue

Brain

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional repressor CTCF (CTCF) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [3]

TF Protein Name

Myc-associated zinc finger protein Transcription Factor Info

Tissue

Blood; Cervix; Lung

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myc-associated zinc finger protein (MAZ) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in podocyte condition [9]

TF Protein Name

Wilms tumor protein Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Wilms tumor protein (WT1) has been reported to activate the transcription of SLC9A7 gene in podocyte condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

Zinc finger protein 263 Transcription Factor Info

Tissue

Bone marrow; Kidney

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Zinc finger protein 263 (ZNF263) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PBX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in ovarian cancer condition [10]

TF Protein Name

Pre-B-cell leukemia transcription factor 1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC9A7 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

Transcription factor E2F1 Transcription Factor Info

Tissue

Blood; Breast

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor E2F1 (E2F1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        FOXM1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Activation of SLC9A7 gene in breast cancer condition [11]

TF Protein Name

Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Up regulating

Detailed Description

Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC9A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 7.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [5]

TF Protein Name

Forkhead box protein P1 Transcription Factor Info

Tissue

Embryo; Prostate

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Forkhead box protein P1 (FOXP1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

Transcriptional regulator ERG Transcription Factor Info

Tissue

Aorta

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcriptional regulator ERG (ERG) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC9A7 gene in megakaryocytes condition [12]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

Direct regulating

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC9A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7.

       Transcriptional Phenomenon2

Direct binding to SLC9A7 gene [3]

TF Protein Name

Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

Blood; Mesenchymal; Vein

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [1]

TF Protein Name

Transcription factor PU.1 Transcription Factor Info

Tissue

Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor PU.1 (SPI1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

        SPIB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

Transcription factor Spi-B Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor Spi-B (SPIB) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MEF2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [2]

TF Protein Name

Myocyte-specific enhancer factor 2A Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        EBF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [3]

TF Protein Name

Transcription factor COE1 Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Transcription factor COE1 (EBF1) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC9A7 gene in glioblastoma multiforme condition [13]

TF Protein Name

Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

Temozolomide

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC9A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Binding to SLC9A7 gene in epithelial to mesenchymal transition condition [14]

TF Protein Name

Tumor protein 63 Transcription Factor Info

Studied Phenotype

.

Related DT Changes

Direct regulating

Detailed Description

Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC9A7 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 7.

      Class6.7: Grainyhead domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GRHL2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [5]

TF Protein Name

Grainyhead-like protein 2 homolog Transcription Factor Info

Tissue

Bronchus; Ovary

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

Direct binding to SLC9A7 gene [5]

TF Protein Name

Nuclear factor 1 C-type Transcription Factor Info

Tissue

Blood

Related DT Changes

Direct regulating

Experiment method

TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

Nuclear factor 1 C-type (NFIC) can directly bind to the SLC9A7 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 7.
References
1 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-154. (ID:ENSG00000065923)
3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
4 High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
7 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
8 Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult Scler. 2013;19(8):1035-45.
9 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
10 Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
11 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
12 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
13 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
14 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.

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