Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0480 Transporter Info
Gene Name SLC8B1
Transporter Name Mitochondrial sodium/calcium exchanger protein
Gene ID
80024
UniProt ID
Q6J4K2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        ATF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        CEBPD 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 CCAAT/enhancer-binding protein delta Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        FOSL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Fos-related antigen 1 Transcription Factor Info

Tissue

 Bone marrow; Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Fos-related antigen 1 (FOSL1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        BHLHE40 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Class E basic helix-loop-helix protein 40 Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        MITF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Microphthalmia-associated transcription factor Transcription Factor Info

Tissue

 Epithelium; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Microphthalmia-associated transcription factor (MITF) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene in Coronary Artery Disease condition [5]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLC8B1 gene in Coronary Artery Disease condition, which affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        USF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Upstream stimulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Colon; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 1 (USF1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        USF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Upstream stimulatory factor 2 Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Upstream stimulatory factor 2 (USF2) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class1.3: Basic helix-span-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TFAP2C 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Transcription factor AP-2 gamma Transcription Factor Info

Tissue

 Breast; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 11 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC8B1 gene in erythroleukemia condition [6]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC8B1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        KLF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Krueppel-like factor 1 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 1 (KLF1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Foreskin; Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Colon; Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Embryo; Liver; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Bone marrow; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class2.9: C2CH THAP-type zinc finger factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        THAP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 THAP domain-containing protein 1 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 THAP domain-containing protein 1 (THAP1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        PBX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Pre-B-cell leukemia transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Embryo; Endoderm; Liver; Lung; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 9 TF(s) Regulating This DT

        ELK3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC8B1 gene in hypoxia condition [7]

TF Protein Name

 ETS domain-containing protein Elk-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC8B1 gene in hypoxia condition, which leads to an affected expression of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        ETS1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone; Bone marrow; Kidney; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        FLI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Bone marrow; Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [4]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        MYB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [1]

TF Protein Name

 Transcriptional activator Myb Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional activator Myb (MYB) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [2]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

        SPIB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC8B1 gene [3]

TF Protein Name

 Transcription factor Spi-B Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Spi-B (SPIB) can directly bind to the SLC8B1 gene, which in turn affects the expression or function of the drug transporter Mitochondrial sodium/calcium exchanger protein.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC8B1 gene in fibrosarcoma condition [8]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to activate the transcription of SLC8B1 gene in fibrosarcoma condition, which leads to an increased expression of the drug transporter Mitochondrial sodium/calcium exchanger protein.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC8B1 gene in glioblastoma multiforme condition [9]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC8B1 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Mitochondrial sodium/calcium exchanger protein.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-172. (ID:ENSG00000089060)
5 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
6 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
7 The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
8 Modulation of gene expression regulated by the transcription factor NF-B/RelA. J Biol Chem. 2014;289(17):11927-11944.
9 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.

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