Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0479 Transporter Info
Gene Name SLC8A3
Transporter Name Sodium/calcium exchanger 3
Gene ID
6547
UniProt ID
P57103

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

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        HIF1A 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in hypoxia condition [1]

TF Protein Name

 Hypoxia-inducible factor 1-alpha Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to bind to the transcription of SLC8A3 gene in hypoxia condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC8A3 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC8A3 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Sodium/calcium exchanger 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in health condition [3]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC8A3 gene in health condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

      Class2.2: Other C4 zinc finger-type factors

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        GATA1 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in megakaryocytes condition [4]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC8A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in erythroleukemia condition [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC8A3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

        MAZ 

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       Transcriptional Phenomenon1

 Direct binding to SLC8A3 gene [6]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC8A3 gene, which in turn affects the expression or function of the drug transporter Sodium/calcium exchanger 3.

        SALL4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC8A3 gene in health condition [7]

TF Protein Name

 Sal-like protein 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC8A3 gene in health condition, which leads to an increased expression of the drug transporter Sodium/calcium exchanger 3.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CUX1 

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       Transcriptional Phenomenon1

 Activation of SLC8A3 gene in multiple human cancer types condition [8]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC8A3 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Sodium/calcium exchanger 3.

      Class3.3: Fork head / winged helix factors

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        E2F1 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in MCF7 cells [9]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F1 (E2F1) has been reported to bind to the transcription of SLC8A3 gene in MCF7 cells, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

        E2F4 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in health condition [10]

TF Protein Name

 Transcription factor E2F4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of SLC8A3 gene in health condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

        FOXO3 

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       Transcriptional Phenomenon1

 Activation of SLC8A3 gene in DLD1 condition [11]

TF Protein Name

 Forkhead box protein O3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein O3 (FOXO3) has been reported to activate the transcription of SLC8A3 gene in DLD1 condition, which leads to an increased expression of the drug transporter Sodium/calcium exchanger 3.

      Class3.5: Tryptophan cluster factors

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        FLI1 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in megakaryocytes condition [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC8A3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

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        STAT3 

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       Transcriptional Phenomenon1

 Binding to SLC8A3 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC8A3 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Sodium/calcium exchanger 3.

      Class6.5: T-Box factors

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        EOMES 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC8A3 gene in health condition [12]

TF Protein Name

 Eomesodermin homolog Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Eomesodermin homolog (EOMES) has been reported to activate the transcription of SLC8A3 gene in health condition, which leads to an increased expression of the drug transporter Sodium/calcium exchanger 3.

TF Superclass10: Yet undefined DNA-binding domains

      Class10.1: Other factors

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        KCNIP3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC8A3 gene in brain neuroblastoma condition [13]

TF Protein Name

 Calsenilin Transcription Factor Info

Studied Phenotype

 Brain neuroblastoma [ICD11: 2A00.11]

Tissue

 Brain

Related DT Changes

 Down regulating

Experimental Material

 Human neuroblastoma cells (SH-SY5Y)

Detailed Description

 Calsenilin (KCNIP3) has been reported to repress the transcription of SLC8A3 gene in brain neuroblastoma condition, which leads to a decreased expression of the drug transporter Sodium/calcium exchanger 3.
References
1 High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 2011;117(23):e207-17.
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
4 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
5 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-184. (ID:ENSG00000100678)
7 SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
8 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
9 A computational genomics approach to identify cis-regulatory modules from chromatin immunoprecipitation microarray data--a case study using E2F1. Genome Res. 2006;16(12):1585-95.
10 Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis. Nucleic Acids Res. 2011;39(9):3558-73.
11 Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol. 2013;9:638.
12 Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011;25(3):238-50.
13 Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons. J Neurosci. 2005 Nov 23;25(47):10822-30.

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