| General Information of DT | |||||
|---|---|---|---|---|---|
| DT ID | DTD0479 | ||||
| Gene Name | SLC8A3 | ||||
| Protein Name | Sodium/calcium exchanger 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| TCDB ID | |||||
| 3D Structure |
Modelled DT Structure Method:homology modeling Template PDB:6BV7_A; 3US9_A Identity:72.093%;64.483% Minimized Score:-553.566 kcal/mol Detail: Structure Info |
||||
| Synonyms | NCX3; Na(+)/Ca(2+)-exchange protein 3; SLC8A3; Solute carrier family 8 member 3 | ||||
| DT Family | Ca(2+):Cation Antiporter (CACA) Family ; | ||||
| Tissue Specificity | Isoform 2 is expressed in brain and skeletalmuscle. Isoform 3 is expressed in excitable cells of brain, retinaand skeletal muscle. Isoform 4 is expressed in skeletal muscle. | ||||
| Function | This transporter mediates the electrical exchange of calcium ions and sodium ions on the cell membrane and contributes to the calcium homeostasis of excitable cells in muscles and brain. | ||||
| Endogenous Substrate(s) | Ca2+; Na+ | ||||
| Variability Data of This Drug Transporter (DT) | |||||
|
Regulatory Variability Data of This DT (VARIDT 4.0) |
|||||
|
(α) Tissue Distribution Level of Sodium/calcium exchanger 3 |
|||||
|
(β) Cell Distribution Level of Sodium/calcium exchanger 3 |
|||||
|
(γ) Organelle Distribution Level of Sodium/calcium exchanger 3 |
|||||
|
Regulatory Variability Data of This DT |
|||||
|
(β) Post-translational Modification of Sodium/calcium exchanger 3 |
|||||
|
(γ) Transcriptional Regulation of Sodium/calcium exchanger 3 |
|||||
|
(δ) Epigenetic Regulation of Sodium/calcium exchanger 3 |
|||||
|
(ε) Exogenous Modulation of Sodium/calcium exchanger 3 |
|||||
|
Structural Variability Data of This DT |
|||||
|
(β) Inter-species Structural Differences |
|||||
|
General Variability Data of This DT |
|||||
|
(α) Genetic Polymorphisms of Sodium/calcium exchanger 3 |
|||||
|
(β) Disease-specific Protein Abundances of Sodium/calcium exchanger 3 |
|||||
|
(γ) Species- and Tissue-specific DT Abundances |
|||||
If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.