Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0367 Transporter Info
Gene Name SLC44A5
Transporter Name Choline transporter-like protein 5
Gene ID
204962
UniProt ID
Q8NCS7

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        MYC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC44A5 gene in medulloblastoma condition [1]

TF Protein Name

 Myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC44A5 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Choline transporter-like protein 5.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC44A5 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC44A5 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC44A5 gene in erythroleukemia condition [3]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC44A5 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

        WT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC44A5 gene in podocyte condition [4]

TF Protein Name

 Wilms tumor protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Wilms tumor protein (WT1) has been reported to activate the transcription of SLC44A5 gene in podocyte condition, which leads to an increased expression of the drug transporter Choline transporter-like protein 5.

TF Superclass3: Helix-turn-helix domains

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC44A5 gene in K562 cells [5]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC44A5 gene in K562 cells, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC44A5 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC44A5 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP53 

Click to Show/Hide to Show 3 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC44A5 gene in HFKS condition [6]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC44A5 gene in HFKS condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

       Transcriptional Phenomenon2

 Binding to SLC44A5 gene in tumorigenesis condition [7]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC44A5 gene in tumorigenesis condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.

       Transcriptional Phenomenon3

 Activation of SLC44A5 gene in atherosclerosis condition [8]

TF Protein Name

 Cellular tumor antigen p53 Transcription Factor Info

Studied Phenotype

 Atherosclerosis [ICD11: BD40]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 Human hepatoblastoma cells (HepG2)

Detailed Description

 Cellular tumor antigen p53 (TP53) has been reported to activate the transcription of SLC44A5 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter Choline transporter-like protein 5.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        SMAD3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC44A5 gene in health condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to activate the transcription of SLC44A5 gene in health condition, which leads to an increased expression of the drug transporter Choline transporter-like protein 5.

        SMAD4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC44A5 gene in health condition [9]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC44A5 gene in health condition, which leads to an increased expression of the drug transporter Choline transporter-like protein 5.

       Transcriptional Phenomenon2

 Binding to SLC44A5 gene in epithelial ovarian cancer condition [10]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC44A5 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Choline transporter-like protein 5.
References
1 Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
4 Alternatively spliced isoforms of WT1 control podocyte-specific gene expression. Kidney Int. 2015;88(2):321-31.
5 Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
6 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
7 A global map of p53 transcription-factor binding sites in the human genome. Cell. 2006;124(1):207-19.
8 p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62.
9 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.
10 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.