Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0348 Transporter Info
Gene Name	SLC39A7
Transporter Name	Zinc transporter SLC39A7
Gene ID	7922
UniProt ID	Q92504

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A7 gene in breast cancer bone metastasis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC39A7 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Zrt- Irt-like protein 7.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone marrow; Breast; Cervix; Colon; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Blood; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Colon; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
MNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Max-binding protein MNT		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-binding protein MNT (MNT) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Bone marrow; Brain; Cervix; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc proto-oncogene protein (MYC) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A7 gene in health condition			[6]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC39A7 gene in health condition, which leads to an affected expression of the drug transporter Zrt- Irt-like protein 7.
HNF4G		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 4-gamma		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC39A7 gene in myofibroblast condition			[7]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC39A7 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Zrt- Irt-like protein 7.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 13 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
CTCFL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Transcriptional repressor CTCFL		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Colon; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Embryo; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
PRDM14		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	PR domain zinc finger protein 14		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	PR domain zinc finger protein 14 (PRDM14) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
SALL4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC39A7 gene in health condition			[8]
TF Protein Name	Sal-like protein 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC39A7 gene in health condition, which leads to an increased expression of the drug transporter Zrt- Irt-like protein 7.
YY1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Transcriptional repressor protein YY1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Cervix; Colon; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A7 gene			[6]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC39A7 gene in . condition, which leads to a affected expression of the drug transporter Zrt- Irt-like protein 7.
Transcriptional Phenomenon2	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC39A7 gene in embryonic stem cell condition			[9]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC39A7 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Zrt- Irt-like protein 7.
RFX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	DNA-binding protein RFX5		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	DNA-binding protein RFX5 (RFX5) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 6 TF(s) Regulating This DT
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Umbilical cord blood; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
SPI1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC39A7 gene in K562 cells			[10]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC39A7 gene in K562 cells, which leads to an affected expression of the drug transporter Zrt- Irt-like protein 7.
Transcriptional Phenomenon2	Direct binding to SLC39A7 gene			[5]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[5]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[3]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[2]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene in HFKS condition			[11]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC39A7 gene in HFKS condition, which leads to an affected expression of the drug transporter Zrt- Irt-like protein 7.
Transcriptional Phenomenon2	Binding to SLC39A7 gene in health condition			[12]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC39A7 gene in health condition, which leads to an affected expression of the drug transporter Zrt- Irt-like protein 7.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC39A7 gene			[4]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC39A7 gene, which in turn affects the expression or function of the drug transporter Zrt- Irt-like protein 7.

References
1	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-217. (ID:ENSG00000112473)
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
7	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
8	SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
9	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
10	Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
11	Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
12	Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.

Detail Information of Transcriptional Regulations

Visitor Map

Correspondence