Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0300 Transporter Info
Gene Name SLC35D3
Transporter Name Fringe connection-like protein 1
Gene ID
340146
UniProt ID
Q5M8T2

Transcriptional Regulation of This DT (TSR)

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        ISL1 

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       Transcriptional Phenomenon1

 Activation of SLC35D3 gene in health condition [1]

TF Protein Name

 Insulin gene enhancer protein ISL-1 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Brain

Related DT Changes

 Up regulating

Experimental Material

 C57/BL6J mice

Detailed Description

 Insulin gene enhancer protein ISL-1 (ISL1) has been reported to activate the transcription of SLC35D3 gene in health condition, which leads to an increased expression of the drug transporter Fringe connection-like protein 1.

      Class3.3: Fork head / winged helix factors

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        FOXM1 

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       Transcriptional Phenomenon1

 Activation of SLC35D3 gene in breast cancer condition [2]

TF Protein Name

 Forkhead box protein M1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC35D3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Fringe connection-like protein 1.

      Class3.5: Tryptophan cluster factors

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        ERG 

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       Transcriptional Phenomenon1

 Activation of SLC35D3 gene in leukemia condition [3]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcriptional regulator ERG (ERG) has been reported to activate the transcription of SLC35D3 gene in leukemia condition, which leads to an increased expression of the drug transporter Fringe connection-like protein 1.

        FLI1 

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       Transcriptional Phenomenon1

 Direct binding to SLC35D3 gene [4]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC35D3 gene, which in turn affects the expression or function of the drug transporter Fringe connection-like protein 1.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

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        SOX2 

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       Transcriptional Phenomenon1

 Activation of SLC35D3 gene in colorectal cancer condition [5]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of SLC35D3 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Fringe connection-like protein 1.

TF Superclass6: Immunoglobulin fold

      Class6.4: Runt domain factors

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        RUNX1 

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       Transcriptional Phenomenon1

 Binding to SLC35D3 gene in megakaryocytes condition [6]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC35D3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Fringe connection-like protein 1.
References
1 Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77.
2 FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
3 Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG. Oncogene. 2011;30(17):2044-56.
4 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-423. (ID:ENSG00000182747)
5 ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
6 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.

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