Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0291 Transporter Info
Gene Name SLC35A5
Transporter Name Probable UDP-sugar transporter protein SLC35A5
Gene ID
55032
UniProt ID
Q9BS91

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ATF2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-2 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-2 (ATF2) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        ATF3 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC35A5 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Down regulating

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of SLC35A5 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

       Transcriptional Phenomenon2

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Cyclic AMP-dependent transcription factor ATF-3 Transcription Factor Info

Tissue

 Blood; Bone marrow; Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        CREB1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC35A5 gene in health condition [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) has been reported to activate the transcription of SLC35A5 gene in health condition, which leads to an increased expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

       Transcriptional Phenomenon2

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Embryo; Liver; Lung; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [6]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor Jun (JUN) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        ARNTL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Basic helix-loop-helix ARNT-like protein 1 Transcription Factor Info

Tissue

 Bone; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Basic helix-loop-helix ARNT-like protein 1 (ARNTL) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        CLOCK 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Circadian locomoter output cycles protein kaput Transcription Factor Info

Tissue

 Bone; Brain; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Circadian locomoter output cycles protein kaput (CLOCK) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        MAX 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [6]

TF Protein Name

 Protein max Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein max (MAX) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in health condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to bind to the transcription of SLC35A5 gene in health condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        GATA4 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC35A5 gene in gastric cancer condition [8]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC35A5 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

       Transcriptional Phenomenon2

 Direct binding to SLC35A5 gene [6]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Tissue

 Heart

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor GATA-4 (GATA4) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        KLF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Krueppel-like factor 4 Transcription Factor Info

Tissue

 Pancreatic ductal; Skin

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 4 (KLF4) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Tissue

 Pancreatic ductal; Stomach

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 5 (KLF5) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        E2F1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 Transcription factor E2F1 Transcription Factor Info

Tissue

 Mesenchymal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2F1 (E2F1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Tissue

 Breast; Embryo; Liver; Pancreatic ductal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Tissue

 Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 8 TF(s) Regulating This DT

        EHF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [6]

TF Protein Name

 ETS homologous factor Transcription Factor Info

Tissue

 Bronchus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS homologous factor (EHF) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        ELK1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [9]

TF Protein Name

 ETS domain-containing protein Elk-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS domain-containing protein Elk-1 (ELK1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        ETS1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC35A5 gene in T cell activation condition [10]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Related DT Changes

 Up regulating

Detailed Description

 Protein C-ets-1 (ETS1) has been reported to activate the transcription of SLC35A5 gene in T cell activation condition, which leads to an increased expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

       Transcriptional Phenomenon2

 Direct binding to SLC35A5 gene [6]

TF Protein Name

 Protein C-ets-1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Kidney; Lung; Prostate; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Protein C-ets-1 (ETS1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in megakaryocytes condition [11]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC35A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

       Transcriptional Phenomenon2

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Umbilical cord blood; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [1]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Cervix; Liver; Lung; Mesenchymal; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        IRF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [5]

TF Protein Name

 Interferon regulatory factor 1 Transcription Factor Info

Tissue

 Blood; Bone marrow; Pancreatic ductal

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Interferon regulatory factor 1 (IRF1) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in APL condition [12]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC35A5 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in glioblastoma multiforme condition [13]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC35A5 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in megakaryocytes condition [11]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC35A5 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFIC 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC35A5 gene [3]

TF Protein Name

 Nuclear factor 1 C-type Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Nuclear factor 1 C-type (NFIC) can directly bind to the SLC35A5 gene, which in turn affects the expression or function of the drug transporter Probable UDP-sugar transporter protein SLC35A5.

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC35A5 gene in epithelial ovarian cancer condition [14]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC35A5 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Probable UDP-sugar transporter protein SLC35A5.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 In vivo RNAi screen for BMI1 targets identifies TGF-BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis. Cancer Cell. 2013;23(5):660-76.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-286. (ID:ENSG00000138459)
4 Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102(12):4459-64.
5 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
6 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
7 Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease. BMC Med. 2013;11:163.
8 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9 ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. PLoS Genet. 2012;8(5):e1002694.
10 DNA specificity determinants associate with distinct transcription factor functions. PLoS Genet. 2009;5(12):e1000778.
11 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
12 Structurally differentiated cis-elements that interact with PU.1 are functionally distinguishable in acute promyelocytic leukemia. J Hematol Oncol. 2013;6:25.
13 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
14 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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