Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0248 Transporter Info | ||||
Gene Name | SLC29A2 | ||||
Transporter Name | Equilibrative nucleoside transporter 2 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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CEBPB |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein beta | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
FOSL2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Fos-related antigen 2 | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Fos-related antigen 2 (FOSL2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class1.2: Basic helix-loop-helix factors |
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ARNT |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ASCL2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Achaete-scute homolog 2 | Transcription Factor Info | ||||
Tissue |
Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Achaete-scute homolog 2 (ASCL2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
BHLHE40 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Class E basic helix-loop-helix protein 40 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
HEY1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Hairy/enhancer-of-split related with YRPW motif protein 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
HIF1A |
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Transcriptional Phenomenon1 |
Repression of SLC29A2 gene in intestinal inflammation condition | [5] | ||||
TF Protein Name |
Hypoxia-inducible factor 1-alpha | Transcription Factor Info | ||||
Studied Phenotype |
Intestinal inflammation [ICD11: 1A40.Z] | |||||
Tissue |
Colon | |||||
Related DT Changes |
Down regulating | |||||
Experimental Material |
C57BL/6 mice | |||||
Detailed Description |
Hypoxia-inducible factor 1-alpha (HIF1A) has been reported to repress the transcription of SLC29A2 gene in intestinal inflammation condition, which leads to a decreased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
MITF |
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Transcriptional Phenomenon1 |
Activation of SLC29A2 gene in melanoma condition | [6] | ||||
TF Protein Name |
Microphthalmia-associated transcription factor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC29A2 gene in melanoma condition, which leads to an increased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
MXI1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Max-interacting protein 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Cervix; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Max-interacting protein 1 (MXI1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
MYOD1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
TCF12 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Transcription factor 12 | Transcription Factor Info | ||||
Tissue |
Blood; Breast; Embryo; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 12 (TCF12) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
TCF3 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class1.3: Basic helix-span-helix factors |
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TFAP2A |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Transcription factor AP-2-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Cervix; Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
TFAP2C |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Cervix; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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ESR1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Estrogen receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Estrogen receptor (ESR1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
NR2F2 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class2.3: C2H2 zinc finger factors |
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BCL6 |
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Transcriptional Phenomenon1 |
Activation of SLC29A2 gene in health condition | [7] | ||||
TF Protein Name |
B-cell lymphoma 6 protein | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of SLC29A2 gene in health condition, which leads to an increased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
B-cell lymphoma 6 protein | Transcription Factor Info | ||||
Tissue |
Blood; Tonsil | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
B-cell lymphoma 6 protein (BCL6) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
CTCF |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcriptional repressor CTCF | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCF (CTCF) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
CTCFL |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcriptional repressor CTCFL | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
EGR1 |
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Transcriptional Phenomenon1 |
Binding to SLC29A2 gene in erythroleukemia condition | [8] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC29A2 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Early growth response protein 1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Breast; Colon; Embryo; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Early growth response protein 1 (EGR1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
HINFP |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Histone H4 transcription factor | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Histone H4 transcription factor (HINFP) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
KLF4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Krueppel-like factor 4 | Transcription Factor Info | ||||
Tissue |
Breast; Pancreatic ductal; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 4 (KLF4) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
KLF5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Krueppel-like factor 5 | Transcription Factor Info | ||||
Tissue |
Colon; Pancreatic ductal; Stomach | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 5 (KLF5) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
KLF9 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Krueppel-like factor 9 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 9 (KLF9) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
MAZ |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
REST |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
RE1-silencing transcription factor | Transcription Factor Info | ||||
Tissue |
Bone marrow; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
RE1-silencing transcription factor (REST) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
SP1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Transcription factor Sp1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Colon; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Sp1 (SP1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
SP4 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcription factor Sp4 | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor Sp4 (SP4) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
VEZF1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Vascular endothelial zinc finger 1 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
YY1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Transcriptional repressor protein YY1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Brain; Colon; Embryo; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional repressor protein YY1 (YY1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZBTB7A |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Zinc finger and BTB domain-containing protein 7A | Transcription Factor Info | ||||
Tissue |
Bone marrow; Liver; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZNF143 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Zinc finger protein 143 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Cervix; Colon; Embryo; Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 143 (ZNF143) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZNF384 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Zinc finger protein 384 | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 384 (ZNF384) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZNF76 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Zinc finger protein 76 | Transcription Factor Info | ||||
Tissue |
Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 76 (ZNF76) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZNF83 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Zinc finger protein 83 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 83 (ZNF83) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class2.9: C2CH THAP-type zinc finger factors |
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THAP11 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
THAP domain-containing protein 11 | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
THAP domain-containing protein 11 (THAP11) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class3.1: Homeo domain factors |
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HOXA1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Homeobox protein Hox-A1 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Homeobox protein Hox-A1 (HOXA1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
PBX1 |
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Transcriptional Phenomenon1 |
Activation of SLC29A2 gene in ovarian cancer condition | [9] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC29A2 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
PBX3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Pre-B-cell leukemia transcription factor 3 | Transcription Factor Info | ||||
Tissue |
Brain | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
POU2F1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
POU domain, class 2, transcription factor 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
SIX5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Homeobox protein SIX5 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Homeobox protein SIX5 (SIX5) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZEB1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Zinc finger E-box-binding homeobox 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class3.2: Paired box factors |
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PAX5 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Paired box protein Pax-5 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Paired box protein Pax-5 (PAX5) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
E2F6 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcription factor E2F6 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F6 (E2F6) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
E2F7 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Transcription factor E2F7 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F7 (E2F7) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
FOXD2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Forkhead box protein D2 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein D2 (FOXD2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
FOXP1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Forkhead box protein P1 | Transcription Factor Info | ||||
Tissue |
Embryo; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein P1 (FOXP1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class3.5: Tryptophan cluster factors |
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ELF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
ETS-related transcription factor Elf-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Breast; Liver; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ELK3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
ETS domain-containing protein Elk-3 | Transcription Factor Info | ||||
Tissue |
Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ELK4 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
ETS domain-containing protein Elk-4 | Transcription Factor Info | ||||
Tissue |
Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS domain-containing protein Elk-4 (ELK4) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ERG |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Tissue |
Blood; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ETS1 |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Lung; Pancreas; Prostate; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ETS2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Protein C-ets-2 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-2 (ETS2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ETV1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
ETS translocation variant 1 | Transcription Factor Info | ||||
Tissue |
Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ETS translocation variant 1 (ETV1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ETV7 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcription factor ETV7 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor ETV7 (ETV7) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
FLI1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC29A2 gene in megakaryocytes condition | [10] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLC29A2 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
GABPA |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
GA-binding protein alpha chain | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
GA-binding protein alpha chain (GABPA) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
IRF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Interferon regulatory factor 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Pancreatic ductal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Interferon regulatory factor 1 (IRF1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
MYB |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Transcriptional activator Myb | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional activator Myb (MYB) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
SPI1 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC29A2 gene in APL condition | [11] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC29A2 gene in acute promyelocytic leukemia (APL) condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Transcriptional Phenomenon2 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class3.7: ARID domain factors |
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KDM5B |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Lysine-specific demethylase 5B | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class4.2: Heteromeric CCAAT-binding factors |
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NFYA |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [4] | ||||
TF Protein Name |
Nuclear transcription factor Y subunit alpha | Transcription Factor Info | ||||
Tissue |
Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class5.1: MADS box factors |
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SRF |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Serum response factor | Transcription Factor Info | ||||
Tissue |
Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Serum response factor (SRF) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class6.1: Rel homology region factors |
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NFKB1 |
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Transcriptional Phenomenon1 |
Repression of SLC29A2 gene in acute lung injury condition | [12] | ||||
TF Protein Name |
Nuclear factor NF-kappa-B p105 subunit | Transcription Factor Info | ||||
Affected Drug/Substrate |
Adenosine | |||||
Studied Phenotype |
Acute lung injury [ICD11: NB32.3Z] | |||||
Related DT Changes |
Down regulating | |||||
Experimental Material |
C57BL/6 mice | |||||
Detailed Description |
Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of SLC29A2 gene in acute lung injury condition, which leads to a decreased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
RBPJ |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to SLC29A2 gene in immortal lymphoblast cell lines (LCLs) condition | [13] | ||||
TF Protein Name |
Recombining binding protein suppressor of hairless | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC29A2 gene in immortal lymphoblast cell lines (LCLs) condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class6.3: p53 domain factors |
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TP63 |
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Transcriptional Phenomenon1 |
Binding to SLC29A2 gene in health condition | [14] | ||||
TF Protein Name |
Tumor protein 63 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC29A2 gene in health condition, which leads to an affected expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class6.5: T-Box factors |
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EOMES |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of SLC29A2 gene in health condition | [15] | ||||
TF Protein Name |
Eomesodermin homolog | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Eomesodermin homolog (EOMES) has been reported to activate the transcription of SLC29A2 gene in health condition, which leads to an increased expression of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class10.1: Other factors |
Click to Show/Hide the Full List of 2 TF(s) Regulating This DT |
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PCGF2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [1] | ||||
TF Protein Name |
Polycomb group RING finger protein 2 | Transcription Factor Info | ||||
Tissue |
Foreskin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Polycomb group RING finger protein 2 (PCGF2) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
ZBTB10 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [2] | ||||
TF Protein Name |
Zinc finger and BTB domain-containing protein 10 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger and BTB domain-containing protein 10 (ZBTB10) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
Class10.5: GTF2I domain factors |
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GTF2I |
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Transcriptional Phenomenon1 |
Direct binding to SLC29A2 gene | [3] | ||||
TF Protein Name |
General transcription factor II-I | Transcription Factor Info | ||||
Tissue |
Foreskin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
General transcription factor II-I (GTF2I) can directly bind to the SLC29A2 gene, which in turn affects the expression or function of the drug transporter Equilibrative nucleoside transporter 2. | |||||
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