Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0183 Transporter Info
Gene Name	SLC25A22
Transporter Name	Mitochondrial glutamate carrier 1
Gene ID	79751
UniProt ID	Q9H936

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
BATF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Basic leucine zipper transcriptional factor ATF-like		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
XBP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	X-box-binding protein 1		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	X-box-binding protein 1 (XBP1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Colon; Embryo; Liver; Lung; Uterus; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A22 gene in Burkitt lymphoma condition			[5]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC25A22 gene in Burkitt lymphoma condition, which leads to a decreased expression of the drug transporter Mitochondrial glutamate carrier 1.
MYOD1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Myoblast determination protein 1		Transcription Factor Info
Tissue	Myotube
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myoblast determination protein 1 (MYOD1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A22 gene in coronary artery disease condition			[6]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 21 (TCF21) has been reported to bind to the transcription of SLC25A22 gene in coronary artery disease condition, which leads to a affected expression of the drug transporter Mitochondrial glutamate carrier 1.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Embryo; Liver; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A22 gene in myofibroblast condition			[7]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC25A22 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Mitochondrial glutamate carrier 1.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 15 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
CTCFL		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Transcriptional repressor CTCFL		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Colon; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Breast; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
MECOM		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Histone-lysine N-methyltransferase MECOM		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Tissue	Blood; Bone marrow; Colon; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp1 (SP1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
SP4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Transcription factor Sp4		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor Sp4 (SP4) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ZBTB7B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Zinc finger and BTB domain-containing protein 7B		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7B (ZBTB7B) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
NKX2-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Homeobox protein Nkx-2.1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ZEB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Zinc finger E-box-binding homeobox 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger E-box-binding homeobox 1 (ZEB1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
E2F7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Transcription factor E2F7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F7 (E2F7) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOXP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC25A22 gene in embryonic stem cell condition			[8]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Forkhead box protein P1 (FOXP1) has been reported to repress the transcription of SLC25A22 gene in embryonic stem cell condition, which leads to a decreased expression of the drug transporter Mitochondrial glutamate carrier 1.
Transcriptional Phenomenon2	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FOXP2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Forkhead box protein P2		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P2 (FOXP2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
RFX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	DNA-binding protein RFX2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	DNA-binding protein RFX2 (RFX2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 11 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Lung; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A22 gene in hypoxia condition			[9]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of SLC25A22 gene in hypoxia condition, which leads to an affected expression of the drug transporter Mitochondrial glutamate carrier 1.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	GastroIntestine tract; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
IRF1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC25A22 gene in health condition			[10]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Interferon regulatory factor 1 (IRF1) has been reported to activate the transcription of SLC25A22 gene in health condition, which leads to an increased expression of the drug transporter Mitochondrial glutamate carrier 1.
Transcriptional Phenomenon2	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
IRF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Interferon regulatory factor 2		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 2 (IRF2) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Blood; Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[2]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
RBPJ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A22 gene in immortal lymphoblast cell lines condition			[11]
TF Protein Name	Recombining binding protein suppressor of hairless		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC25A22 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Mitochondrial glutamate carrier 1.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[1]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC25A22 gene in health condition			[12]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of SLC25A22 gene in health condition, which leads to an affected expression of the drug transporter Mitochondrial glutamate carrier 1.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Tissue	Thyroid
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Tumor protein 63 (TP63) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[4]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC25A22 gene			[3]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the SLC25A22 gene, which in turn affects the expression or function of the drug transporter Mitochondrial glutamate carrier 1.

References
1	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-410. (ID:ENSG00000177542)
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5	Deep sequencing of MYC DNA-binding sites in Burkitt lymphoma. PLoS One. 2011;6(11):e26837.
6	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
7	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
8	An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-46.
9	The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PLoS One. 2014;9(11):e113050.
10	Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene. 2011;487(1):21-8.
11	Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
12	Distinct p53 genomic binding patterns in normal and cancer-derived human cells. Cell Cycle. 2011;10(24):4237-49.

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