Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0160 Transporter Info
Gene Name	SLC23A3
Transporter Name	Na(+)/L-ascorbic acid transporter 3
Gene ID	151295
UniProt ID	Q6PIS1

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
FOS		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Protein c-Fos		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein c-Fos (FOS) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
MAX		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Protein max		Transcription Factor Info
Tissue	Blood; Bone marrow; Brain; Breast; Liver; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein max (MAX) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
MITF		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC23A3 gene in melanoma condition			[5]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of SLC23A3 gene in melanoma condition, which leads to an increased expression of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Transcriptional Phenomenon2	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Microphthalmia-associated transcription factor		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Microphthalmia-associated transcription factor (MITF) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Cervix; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TAL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	T-cell acute lymphocytic leukemia protein 1		Transcription Factor Info
Tissue	Blood; Colon; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	T-cell acute lymphocytic leukemia protein 1 (TAL1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Blood; Brain; Embryo; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Cervix; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
HNF4G		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 4-gamma		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 4-gamma (HNF4G) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
PGR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Progesterone receptor (PGR) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC23A3 gene in myofibroblasts condition			[6]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC23A3 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Na(+)/L-ascorbic acid transporter 3.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GATA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Endothelial transcription factor GATA-2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Endothelial transcription factor GATA-2 (GATA2) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 13 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
SALL4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC23A3 gene in health condition			[7]
TF Protein Name	Sal-like protein 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Sal-like protein 4 (SALL4) has been reported to activate the transcription of SLC23A3 gene in health condition, which leads to an increased expression of the drug transporter Na(+)/L-ascorbic acid transporter 3.
VEZF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Vascular endothelial zinc finger 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ZNF92		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Zinc finger protein 92		Transcription Factor Info
Tissue	Retina
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 92 (ZNF92) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation and repression of SLC23A3 gene in multiple human cancer types condition			[8]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate and repress the transcription of SLC23A3 gene in multiple human cancer types condition, which leads to an affected expression of the drug transporter Na(+)/L-ascorbic acid transporter 3.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Liver; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Blood; Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Tissue	Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Brain; Breast; Cervix; Embryo; Liver; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Tissue	Blood; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Interferon regulatory factor 1 (IRF1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[4]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[2]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene in colorectal cancers condition			[9]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to directly bind to the SLC23A3 gene in colorectal cancers condition, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Embryo; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RBPJ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC23A3 gene in immortal lymphoblast cell lines condition			[10]
TF Protein Name	Recombining binding protein suppressor of hairless		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC23A3 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Na(+)/L-ascorbic acid transporter 3.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[3]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 1 (RUNX1) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.
TF Superclass8: beta-Sheet binding to DNA
Class8.1: TATA-binding proteins		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TBP		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC23A3 gene			[1]
TF Protein Name	TATA-box-binding protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	TATA-box-binding protein (TBP) can directly bind to the SLC23A3 gene, which in turn affects the expression or function of the drug transporter Na(+)/L-ascorbic acid transporter 3.

References
1	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-457. (ID:ENSG00000213901)
4	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5	Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma. Oncogene. 2011;30(20):2319-32.
6	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
7	SALL4 is a key transcription regulator in normal human hematopoiesis. Transfusion. 2013;53(5):1037-49.
8	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
9	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
10	Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.

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