Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0121 Transporter Info
Gene Name SLC17A8
Transporter Name Vesicular glutamate transporter 3
Gene ID
246213
UniProt ID
Q8NDX2

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

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       Transcriptional Phenomenon1

 Direct binding to SLC17A8 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC17A8 gene, which in turn affects the expression or function of the drug transporter Vesicular glutamate transporter 3.

        JUND 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC17A8 gene [2]

TF Protein Name

 Transcription factor JunD Transcription Factor Info

Tissue

 Brain; Cervix; Colon; Coronary artery; Liver; Prostate

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunD (JUND) can directly bind to the SLC17A8 gene, which in turn affects the expression or function of the drug transporter Vesicular glutamate transporter 3.

      Class1.2: Basic helix-loop-helix factors

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        ASCL1 

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       Transcriptional Phenomenon1

 Direct binding to SLC17A8 gene [3]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC17A8 gene, which in turn affects the expression or function of the drug transporter Vesicular glutamate transporter 3.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        HNF4A 

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       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC17A8 gene in health condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

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       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in erythroleukemia condition [5]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC17A8 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CUX1 

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       Transcriptional Phenomenon1

 Activation of SLC17A8 gene in multiple human cancer types condition [6]

TF Protein Name

 Homeobox protein cut-like 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC17A8 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Vesicular glutamate transporter 3.

      Class3.3: Fork head / winged helix factors

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        FOXA1 

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       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in prostate cancer condition [7]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC17A8 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.

      Class3.5: Tryptophan cluster factors

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        ETV4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC17A8 gene in health condition [8]

TF Protein Name

 ETS translocation variant 4 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Dorsal root ganglion

Related DT Changes

 Up regulating

Experimental Material

 Wistar rats

Detailed Description

 ETS translocation variant 4 (ETV4) has been reported to activate the transcription of SLC17A8 gene in health condition, which leads to an increased expression of the drug transporter Vesicular glutamate transporter 3.

        ETV5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC17A8 gene in health condition [8]

TF Protein Name

 ETS translocation variant 5 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Dorsal root ganglion

Related DT Changes

 Up regulating

Experimental Material

 Wistar rats

Detailed Description

 ETS translocation variant 5 (ETV5) has been reported to activate the transcription of SLC17A8 gene in health condition, which leads to an increased expression of the drug transporter Vesicular glutamate transporter 3.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        RBPJ 

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       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in immortal lymphoblast cell lines condition [9]

TF Protein Name

 Recombining binding protein suppressor of hairless Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Recombining binding protein suppressor of hairless (RBPJ) has been reported to bind to the transcription of SLC17A8 gene in immortal lymphoblast cell lines condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.

      Class6.3: p53 domain factors

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        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in health condition [10]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC17A8 gene in health condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC17A8 gene in health condition [11]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC17A8 gene in health condition, which leads to an affected expression of the drug transporter Vesicular glutamate transporter 3.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
3 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-412. (ID:ENSG00000179520)
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
6 p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
7 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
8 Brain-derived neurotrophic factor promotes vesicular glutamate transporter 3 expression and neurite outgrowth of dorsal root ganglion neurons through the activation of the transcription factors Etv4 and Etv5. Brain Res Bull. 2016 Mar;121:215-26.
9 Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011;108(36):14902-7.
10 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
11 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.

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