Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0111 Transporter Info
Gene Name	SLC16A7
Transporter Name	Monocarboxylate transporter 2
Gene ID	9194
UniProt ID	O60669

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in breast cancer bone metastasis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC16A7 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
JUN		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in K562 cells			[4]
TF Protein Name	Transcription factor Jun		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Jun (JUN) has been reported to bind to the transcription of SLC16A7 gene in K562 cells, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[5]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Blood; Cervix; Colon; Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLC16A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in breast cancer condition			[6]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Affected Drug/Substrate	2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) has been reported to activate the transcription of SLC16A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC16A7 gene in medulloblastoma condition			[7]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to repress the transcription of SLC16A7 gene in medulloblastoma condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 2.
TCF21		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[8]
TF Protein Name	Transcription factor 21		Transcription Factor Info
Tissue	Coronary artery
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 21 (TCF21) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
TCF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in glioblastoma multiforme condition			[9]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC16A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[5]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in prostate cancer condition			[10]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC16A7 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[3]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
PPARA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in health condition			[11]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Embryo
Related DT Changes	Up regulating
Experimental Material	CBA/F1 hybrid mice
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC16A7 gene in health condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of SLC16A7 gene in myofibroblast condition			[12]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of SLC16A7 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Monocarboxylate transporter 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[8]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[5]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[2]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in breast cancer condition			[13]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC16A7 gene in breast cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PBX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in ovarian cancer condition			[14]
TF Protein Name	Pre-B-cell leukemia transcription factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Pre-B-cell leukemia transcription factor 1 (PBX1) has been reported to activate the transcription of SLC16A7 gene in ovarian cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[2]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[8]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC16A7 gene in breast cancer condition			[15]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of SLC16A7 gene in breast cancer condition, which leads to an increased expression of the drug transporter Monocarboxylate transporter 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[3]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[5]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[2]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Breast; Embryo; Liver; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.
TF Superclass6: Immunoglobulin fold
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in glioblastoma multiforme condition			[9]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLC16A7 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in megakaryocytes condition			[16]
TF Protein Name	Runt-related transcription factor 1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC16A7 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC16A7 gene in epithelial ovarian cancer condition			[17]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of SLC16A7 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter Monocarboxylate transporter 2.
TF Superclass10: Yet undefined DNA-binding domains
Class10.1: Other factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC16A7 gene			[3]
TF Protein Name	Transcription initiation factor IIB		Transcription Factor Info
Tissue	Cervix; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription initiation factor IIB (GTF2B) can directly bind to the SLC16A7 gene, which in turn affects the expression or function of the drug transporter Monocarboxylate transporter 2.

References
1	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4	c-Jun binding site identification in K562 cells. J Genet Genomics. 2011;38(6):235-42.
5	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-238. (ID:ENSG00000118596)
6	High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci. 2012 Dec;130(2):349-61.
7	Silencing of thrombospondin-1 is critical for myc-induced metastatic phenotypes in medulloblastoma. Cancer Res. 2010;70(20):8199-210.
8	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
9	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
10	Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
11	Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. Reproduction. 2009 Sep;138(3):493-505.
12	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
13	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
14	Identification of PBX1 target genes in cancer cells by global mapping of PBX1 binding sites. PLoS One. 2012;7(5):e36054.
15	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
16	Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
17	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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Detail Information of Transcriptional Regulations

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