Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0038 Transporter Info
Gene Name	ABCA12
Transporter Name	ATP-binding cassette sub-family A member 12
Gene ID	26154
UniProt ID	Q86UK0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
BACH1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in breast cancer bone metastasis condition			[1]
TF Protein Name	Transcription regulator protein BACH1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of ABCA12 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TCF4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in colorectal cancer condition			[2]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to activate the transcription of ABCA12 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Transcriptional Phenomenon2	Binding to ABCA12 gene in glioblastoma multiforme condition			[3]
TF Protein Name	Transcription factor 4		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor 4 (TCF4) has been reported to bind to the transcription of ABCA12 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in harlequin ichthyosis condition			[4]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	Harlequin ichthyosis [ICD11: EC20.02]
Tissue	Skin
Related DT Changes	Up regulating
Experimental Material	human Foreskin keratinocyte isolates
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of ABCA12 gene in harlequin ichthyosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
PPARD		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCA12 gene in myofibroblast condition			[5]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of ABCA12 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Transcriptional Phenomenon2	Activation of ABCA12 gene in harlequin ichthyosis condition			[6]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	Harlequin ichthyosis [ICD11: EC20.02]
Tissue	Skin
Related DT Changes	Up regulating
Experimental Material	human Foreskin keratinocyte isolates
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of ABCA12 gene in harlequin ichthyosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
PPARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in harlequin ichthyosis condition			[6]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Harlequin ichthyosis [ICD11: EC20.02]
Tissue	Skin
Related DT Changes	Up regulating
Experimental Material	human Foreskin keratinocyte isolates
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCA12 gene in harlequin ichthyosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in breast cancer condition			[7]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ABCA12 gene in breast cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in gastric cancer condition			[8]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of ABCA12 gene in gastric cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in erythroleukemia condition			[9]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of ABCA12 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in gastric cancer condition			[8]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of ABCA12 gene in gastric cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in breast cancer condition			[10]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of ABCA12 gene in breast cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in multiple human cancer types condition			[11]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of ABCA12 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in breast cancer condition			[12]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of ABCA12 gene in breast cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
IRF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in health condition			[13]
TF Protein Name	Interferon regulatory factor 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Interferon regulatory factor 1 (IRF1) has been reported to activate the transcription of ABCA12 gene in health condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
TF Superclass6: Immunoglobulin fold
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in glioblastoma multiforme condition			[3]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Temozolomide
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of ABCA12 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TP53		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in stress response condition			[14]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of ABCA12 gene in stress response condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
Transcriptional Phenomenon2	Activation of ABCA12 gene in atherosclerosis condition			[15]
TF Protein Name	Cellular tumor antigen p53		Transcription Factor Info
Studied Phenotype	Atherosclerosis [ICD11: BD40]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Cellular tumor antigen p53 (TP53) has been reported to activate the transcription of ABCA12 gene in atherosclerosis condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in epithelial to mesenchymal transition condition			[16]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCA12 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCA12 gene in prostate cancer condition			[17]
TF Protein Name	Runt-related transcription factor 2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ABCA12 gene in prostate cancer condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SMAD4		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCA12 gene in epithelial ovarian cancer condition			[18]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of ABCA12 gene in epithelial ovarian cancer condition, which leads to an affected expression of the drug transporter ATP-binding cassette sub-family A member 12.
Transcriptional Phenomenon2	Activation of ABCA12 gene in human embryonic stem cells (hESCs) condition			[19]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of ABCA12 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter ATP-binding cassette sub-family A member 12.

References
1	Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2	Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
3	Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
4	PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J Invest Dermatol. 2008 Jan;128(1):104-9.
5	Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor. PLoS One. 2011;6(1):e16344.
6	Keratinocyte differentiation and upregulation of ceramide synthesis induced by an oat lipid extract via the activation of PPAR pathways. Exp Dermatol. 2015 Apr;24(4):290-5.
7	Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC Cancer. 2014;14:278.
8	Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
9	Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
10	Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
11	p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. J Biol Chem. 2009;284(40):27701-11.
12	FOXM1 cistrome predicts breast cancer metastatic outcome better than FOXM1 expression levels or tumor proliferation index. Breast Cancer Res Treat. 2015;154(1):23-32.
13	Genome-wide analysis of interferon regulatory factor I binding in primary human monocytes. Gene. 2011;487(1):21-8.
14	Characterization of genome-wide p53-binding sites upon stress response. Nucleic Acids Res. 2008;36(11):3639-54.
15	p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012 Mar;56(3):656-62.
16	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
17	Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
18	ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.
19	Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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Detail Information of Transcriptional Regulations

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