Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0031 Transporter Info
Gene Name SLCO2B1
Transporter Name Organic anion transporting polypeptide 2B1
Gene ID
11309
UniProt ID
O94956

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in coronary artery disease condition [3]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Jun (JUN) has been reported to bind to the transcription of SLCO2B1 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        JUNB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 Transcription factor JunB Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor JunB (JUNB) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        NFE2L2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in health condition [5]

TF Protein Name

 Nuclear factor erythroid 2-related factor 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of SLCO2B1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 7 TF(s) Regulating This DT

        AHR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in health condition [5]

TF Protein Name

 Aryl hydrocarbon receptor Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of SLCO2B1 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Embryo; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        MYCN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in NEUROBLASTOMA condition [6]

TF Protein Name

 N-myc proto-oncogene protein Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 N-myc proto-oncogene protein (MYCN) has been reported to activate the transcription of SLCO2B1 gene in NEUROBLASTOMA condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Tissue

 Myotube

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myoblast determination protein 1 (MYOD1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        TCF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 Transcription factor 12 Transcription Factor Info

Tissue

 Blood; Brain; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor 12 (TCF12) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        TCF21 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene in coronary artery disease condition [3]

TF Protein Name

 Transcription factor 21 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 21 (TCF21) has been reported to bind to the SLCO2B1 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        TCF3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in health condition [8]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLCO2B1 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        NR1H3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in atherosclerotic foam cells condition [9]

TF Protein Name

 Oxysterols receptor LXR-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLCO2B1 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

        PPARA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO2B1 gene in health condition [5]

TF Protein Name

 Peroxisome proliferator-activated receptor alpha Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 Down regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to repress the transcription of SLCO2B1 gene in health condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 2B1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in hematopoiesis condition [10]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLCO2B1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

       Transcriptional Phenomenon2

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Erythroid transcription factor (GATA1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in hematopoiesis condition [10]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLCO2B1 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        GATA4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in gastric cancer condition [11]

TF Protein Name

 Transcription factor GATA-4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLCO2B1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 10 TF(s) Regulating This DT

        CTCF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 Transcriptional repressor CTCF Transcription Factor Info

Tissue

 Brain

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCF (CTCF) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        CTCFL 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 Transcriptional repressor CTCFL Transcription Factor Info

Tissue

 Bone marrow; Colon

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor CTCFL (CTCFL) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in erythroleukemia condition [12]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLCO2B1 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in gastric cancer condition [11]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLCO2B1 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Bone marrow; Cervix; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        REST 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 RE1-silencing transcription factor Transcription Factor Info

Tissue

 Blood; Bone marrow; Brain; Breast; Embryo; Liver; Lung; Pancreas

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 RE1-silencing transcription factor (REST) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        YY1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 Transcriptional repressor protein YY1 Transcription Factor Info

Tissue

 Colon; Embryo; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional repressor protein YY1 (YY1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        ZBTB7A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 Zinc finger and BTB domain-containing protein 7A Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        ZNF384 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 Zinc finger protein 384 Transcription Factor Info

Tissue

 Bone marrow

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 384 (ZNF384) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        HNF1A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of organic anion transporter protein(OATP) gene in sepsis condition [13]

TF Protein Name

 Hepatocyte nuclear factor 1-alpha Transcription Factor Info

Studied Phenotype

 Sepsis [ICD11: 1G40-1G41]

Tissue

 Liver

Related DT Changes

 Up regulating

Experimental Material

 C57BL/6 mice

Detailed Description

 Hepatocyte nuclear factor 1-alpha (HNF1A) has been reported to activate the transcription of organic anion transporter protein(OATP) gene in sepsis condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

        HNF1B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO2B1 gene in renal cysts condition [14]

TF Protein Name

 Hepatocyte nuclear factor 1-beta Transcription Factor Info

Studied Phenotype

 Renal cysts [ICD11: GB80]

Tissue

 Kidney

Related DT Changes

 Down regulating

Experimental Material

 Zebrafish TgPT::EGFP)

Detailed Description

 Hepatocyte nuclear factor 1-beta (HNF1B) has been reported to repress the transcription of SLCO2B1 gene in renal cysts condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 2B1.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene [8]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLCO2B1 gene in . condition, which leads to a affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        FOXP1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [2]

TF Protein Name

 Forkhead box protein P1 Transcription Factor Info

Tissue

 Colon; Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Forkhead box protein P1 (FOXP1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 5 TF(s) Regulating This DT

        ELF1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene [15]

TF Protein Name

 ETS-related transcription factor Elf-1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 ETS-related transcription factor Elf-1 (ELF1) has been reported to bind to the transcription of SLCO2B1 gene in . condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        ERG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 Transcriptional regulator ERG Transcription Factor Info

Tissue

 Aorta

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcriptional regulator ERG (ERG) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        FLI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in megakaryocytes condition [16]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) has been reported to bind to the transcription of SLCO2B1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

       Transcriptional Phenomenon2

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 Friend leukemia integration 1 transcription factor Transcription Factor Info

Tissue

 Blood; Mesenchymal; Vein

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        GABPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 GA-binding protein alpha chain Transcription Factor Info

Tissue

 Blood; Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 GA-binding protein alpha chain (GABPA) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        SPI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in K562 cells condition [17]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLCO2B1 gene in K562 cells condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

       Transcriptional Phenomenon2

 Direct binding to SLCO2B1 gene [1]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ARID3A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 AT-rich interactive domain-containing protein 3A Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [4]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SRF 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 Serum response factor Transcription Factor Info

Tissue

 Embryo

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Serum response factor (SRF) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass6: Immunoglobulin fold

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in health condition [18]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLCO2B1 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

      Class6.4: Runt domain factors

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        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO2B1 gene in megakaryocytes condition [16]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLCO2B1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 2B1.

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in prostate cancer condition [19]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLCO2B1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO2B1 gene in epithelial ovarian cancer condition [20]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLCO2B1 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 2B1.

TF Superclass8: beta-Sheet binding to DNA

      Class8.1: TATA-binding proteins

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        TBP 

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       Transcriptional Phenomenon1

 Direct binding to SLCO2B1 gene [7]

TF Protein Name

 TATA-box-binding protein Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 TATA-box-binding protein (TBP) can directly bind to the SLCO2B1 gene, which in turn affects the expression or function of the drug transporter Organic anion transporting polypeptide 2B1.
References
1 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
2 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
3 Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
4 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
5 Regulation of mouse organic anion-transporting polypeptides (Oatps) in liver by prototypical microsomal enzyme inducers that activate distinct transcription factor pathways. Drug Metab Dispos. 2005 Sep;33(9):1276-82.
6 Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation. PLoS One. 2009;4(12):e8154.
7 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-281. (ID:ENSG00000137491)
8 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
9 Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res. 2013;41(6):3518-31.
10 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
11 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
12 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
13 IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters. Shock. 2008 Apr;29(4):490-6.
14 Transcriptional profiling of the zebrafish proximal tubule. Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F478-F488.
15 Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 2010;29(13):2147-60.
16 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
17 Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
18 Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation. Nucleic Acids Res. 2012;40(15):7190-206.
19 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
20 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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