Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0023 Transporter Info
Gene Name	SLC22A5
Transporter Name	Organic cation/carnitine transporter 2
Gene ID	6584
UniProt ID	O76082

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
BATF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[]
TF Protein Name	Basic leucine zipper transcriptional factor ATF-like		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Basic leucine zipper transcriptional factor ATF-like (BATF) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[2]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Blood; Breast; Cervix; Colon; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[3]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
CLOCK		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in colorectal cancer condition			[5]
TF Protein Name	Circadian locomoter output cycles protein kaput		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of SLC22A5 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[6]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[7]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TFAP2C		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[8]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of SLC22A5 gene in . condition, which leads to an affected expression of the drug transporter Organic cation/carnitine transporter 2.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[10]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Estrogen receptor (ESR1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
NR1H3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in atherosclerotic foam cells condition			[11]
TF Protein Name	Oxysterols receptor LXR-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Oxysterols receptor LXR-alpha (NR1H3) has been reported to activate the transcription of SLC22A5 gene in atherosclerotic foam cells condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
NR1I2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in health condition			[12]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human liver samples
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous carbamazepine, has been reported to activate the transcription of SLC22A5 gene in health condition , which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[13]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Breast; Epithelium
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
PPARA		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in health condition			[14]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	L-carnitine
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Wistar rats
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC22A5 gene in health condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
Transcriptional Phenomenon2	Activation of SLC22A5 gene in colon cancer condition			[15]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Affected Drug/Substrate	L-carnitine
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Up regulating
Experimental Material	human colon cancer cell isolates
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC22A5 gene in colon cancer condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
Transcriptional Phenomenon3	Activation of SLC22A5 gene in hepatoblastoma condition			[16]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of SLC22A5 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
PPARD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in myofibroblast condition			[17]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to activate the transcription of SLC22A5 gene in myofibroblast condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
RARG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[18]
TF Protein Name	Retinoic acid receptor gamma		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor gamma (RARG) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
RXRG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[19]
TF Protein Name	Retinoic acid receptor RXR-gamma		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Retinoic acid receptor RXR-gamma (RXRG) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[20]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
GATA3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A5 gene in breast cancer condition			[21]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of SLC22A5 gene in breast cancer condition, which leads to an affected expression of the drug transporter Organic cation/carnitine transporter 2.
GATA4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in gastric cancer condition			[22]
TF Protein Name	Transcription factor GATA-4		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of SLC22A5 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
GATA6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in gastric cancer condition			[22]
TF Protein Name	Transcription factor GATA-6		Transcription Factor Info
Affected Drug/Substrate	Metformin
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC22A5 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 7 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[23]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
EGR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[24]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
KLF4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[25]
TF Protein Name	Krueppel-like factor 4		Transcription Factor Info
Tissue	Foreskin; Pancreatic ductal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 4 (KLF4) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
KLF5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[26]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[27]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[28]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[29]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
CUX1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in multiple human cancer types condition			[30]
TF Protein Name	Homeobox protein cut-like 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Homeobox protein cut-like 1 (CUX1) has been reported to activate the transcription of SLC22A5 gene in multiple human cancer types condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
NKX2-1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[31]
TF Protein Name	Homeobox protein Nkx-2.1		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[32]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class3.2: Paired box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
PAX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[33]
TF Protein Name	Paired box protein Pax-5		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Paired box protein Pax-5 (PAX5) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[34]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[35]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[36]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Embryo; Endoderm; Liver; Lung; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[37]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Embryo; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 5 TF(s) Regulating This DT
EHF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[38]
TF Protein Name	ETS homologous factor		Transcription Factor Info
Tissue	Bronchus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS homologous factor (EHF) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[39]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[40]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
MYB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[]
TF Protein Name	Transcriptional activator Myb		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional activator Myb (MYB) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[41]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[42]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Bone marrow; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass5: alpha-Helices exposed by beta-structures
Class5.1: MADS box factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SRF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[43]
TF Protein Name	Serum response factor		Transcription Factor Info
Tissue	Blood; Colon; Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Serum response factor (SRF) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[44]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
STAT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[45]
TF Protein Name	Signal transducer and activator of transcription 1-alpha/beta		Transcription Factor Info
Tissue	Blood; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Signal transducer and activator of transcription 1-alpha/beta (STAT1) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of SLC22A5 gene in health condition			[46]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	L-carnitine
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Blood
Related DT Changes	Up regulating
Experimental Material	human monocyte isolates
Detailed Description	Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of SLC22A5 gene in health condition, which leads to an increased expression of the drug transporter Organic cation/carnitine transporter 2.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to SLC22A5 gene in epithelial to mesenchymal transition condition			[47]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC22A5 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Organic cation/carnitine transporter 2.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[48]
TF Protein Name	Grainyhead-like protein 2 homolog		Transcription Factor Info
Tissue	Breast; Bronchus; Ovary
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[49]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Brain; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.
TF Superclass8: beta-Sheet binding to DNA
Class8.1: TATA-binding proteins		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TBP		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to SLC22A5 gene			[50]
TF Protein Name	TATA-box-binding protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Embryo; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	TATA-box-binding protein (TBP) can directly bind to the SLC22A5 gene, which in turn affects the expression or function of the drug transporter Organic cation/carnitine transporter 2.

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