Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0012 Transporter Info
Gene Name	ABCC3
Transporter Name	Multidrug resistance-associated protein 3
Gene ID	8714
UniProt ID	O15438

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 14 TF(s) Regulating This DT
ATF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-1		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-dependent transcription factor ATF-1 (ATF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ATF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC3 gene in glioblastoma multiforme condition			[2]
TF Protein Name	Cyclic AMP-dependent transcription factor ATF-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of ABCC3 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
BACH2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcription regulator protein BACH2		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription regulator protein BACH2 (BACH2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
CEBPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	CCAAT/enhancer-binding protein alpha		Transcription Factor Info
Tissue	Embryo
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
CEBPB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	CCAAT/enhancer-binding protein beta		Transcription Factor Info
Tissue	Bone
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
CEBPD		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	CCAAT/enhancer-binding protein delta		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
CREB1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Cyclic AMP-responsive element-binding protein 1		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOSL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Fos-related antigen 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 1 (FOSL1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Brain; Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
JUNB		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Transcription factor JunB		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunB (JUNB) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Tissue	Bone marrow; Brain; Breast; Cervix; Colon; Coronary artery; Embryo; Liver; Lung; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor JunD (JUND) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
MAFF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Transcription factor MafF		Transcription Factor Info
Tissue	Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor MafF (MAFF) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
NFE2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcription factor NF-E2 45 kDa subunit		Transcription Factor Info
Tissue	Blood; Bone marrow; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
NFE2L2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in health condition			[6]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of ABCC3 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in gastric signet ring cell adenocarcinoma condition			[7]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Gastric signet ring cell adenocarcinoma [2B72.0]
Tissue	Stomach
Related DT Changes	up regulating
Experimental Material	Human gastric signet ring cell adenocarcinoma cells (SNU-601)
Detailed Description	Aryl hydrocarbon receptor (AHR), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to activate the transcription of ABCC3 gene in gastric signet ring cell adenocarcinoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Activation of ABCC3 gene in health condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCC3 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
ARNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Aryl hydrocarbon receptor nuclear translocator		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ASCL1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Achaete-scute homolog 1		Transcription Factor Info
Tissue	Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Achaete-scute homolog 1 (ASCL1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
BHLHE40		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Class E basic helix-loop-helix protein 40		Transcription Factor Info
Tissue	Bone marrow; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Class E basic helix-loop-helix protein 40 (BHLHE40) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
MNT		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Max-binding protein MNT		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-binding protein MNT (MNT) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
MXI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Max-interacting protein 1		Transcription Factor Info
Tissue	Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Max-interacting protein 1 (MXI1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TCF12		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Transcription factor 12		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor 12 (TCF12) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TCF3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Transcription factor E2-alpha		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2-alpha (TCF3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
USF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Upstream stimulatory factor 1		Transcription Factor Info
Tissue	Brain; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 1 (USF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
USF2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Upstream stimulatory factor 2		Transcription Factor Info
Tissue	Cervix; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Upstream stimulatory factor 2 (USF2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2C		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in breast cancer condition			[8]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) has been reported to activate the transcription of ABCC3 gene in breast cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[3]
TF Protein Name	Transcription factor AP-2 gamma		Transcription Factor Info
Tissue	Breast; Cervix; Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 9 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in prostate cancer condition			[9]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Androgen receptor (AR) has been reported to bind to the transcription of ABCC3 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
ESR1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC3 gene in breast cancer condition			[10]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	down regulating
Experimental Material	Human breast carcinoma cells (MCF-7)
Detailed Description	Estrogen receptor (ESR1), influenced by the exogenous fulvestrant, has been reported to repress the transcription of ABCC3 gene in breast cancer condition , which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
HNF4A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in health condition			[11]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCC3 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
NR1I2		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in colon cancer condition			[12]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Affected Drug/Substrate	Oxaliplatin; 5-fluorouracil
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Up regulating
Experimental Material	human colon cancer cell isolates
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of ABCC3 gene in colon cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Activation of ABCC3 gene in cholestatic liver disease condition			[13]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Cholestatic liver disease [ICD11: DB99]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of ABCC3 gene in cholestatic liver disease condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon3	Activation of ABCC3 gene in health condition			[14]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous estradiol, has been reported to activate the transcription of ABCC3 gene in health condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon4	Activation of ABCC3 gene in head and neck squamous cell carcinoma condition			[15]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Head and neck squamous cell carcinoma [2D60.0]
Tissue	Head and neck
Related DT Changes	up regulating
Experimental Material	Human head and neck squamous cell carcinoma isolates
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous estradiol, has been reported to activate the transcription of ABCC3 gene in head and neck squamous cell carcinoma condition , which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
NR1I3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in health condition			[16]
TF Protein Name	Nuclear receptor subfamily 1 group I member 3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Sprague-Dawley rats
Detailed Description	Nuclear receptor subfamily 1 group I member 3 (NR1I3) has been reported to activate the transcription of ABCC3 gene in health condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
NR2F2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	COUP transcription factor 2		Transcription Factor Info
Tissue	Bone marrow; Breast; Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	COUP transcription factor 2 (NR2F2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
PPARD		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC3 gene in myofibroblasts condition			[17]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of ABCC3 gene in myofibroblasts condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Repression of ABCC3 gene in breast cancer condition			[18]
TF Protein Name	Peroxisome proliferator-activated receptor delta		Transcription Factor Info
Affected Drug/Substrate	ST247 and DG172
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of ABCC3 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
RARA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC3 gene in hepatoblastoma condition			[19]
TF Protein Name	Retinoic acid receptor alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Retinoic acid receptor alpha (RARA) has been reported to repress the transcription of ABCC3 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
RXRA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCC3 gene in hepatoblastoma condition			[19]
TF Protein Name	Retinoic acid receptor RXR-alpha		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Down regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Retinoic acid receptor RXR-alpha (RXRA) has been reported to repress the transcription of ABCC3 gene in hepatoblastoma condition, which leads to a decreased expression of the drug transporter Multidrug resistance-associated protein 3.
Class2.2: Other C4 zinc finger-type factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
GATA1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in megakaryocytes condition			[20]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	Erythroid transcription factor (GATA1) has been reported to bind to the transcription of ABCC3 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[4]
TF Protein Name	Erythroid transcription factor		Transcription Factor Info
Tissue	Blood; Bone marrow; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Erythroid transcription factor (GATA1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
GATA3		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in breast cancer condition			[21]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ABCC3 gene in breast cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[5]
TF Protein Name	Trans-acting T-cell-specific transcription factor GATA-3		Transcription Factor Info
Tissue	Blood; Brain; Breast; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 14 TF(s) Regulating This DT
CTCF		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcriptional repressor CTCF		Transcription Factor Info
Tissue	Brain
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional repressor CTCF (CTCF) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
EGR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in erythroleukemia condition			[22]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Early growth response protein 1 (EGR1) has been reported to bind to the transcription of ABCC3 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[3]
TF Protein Name	Early growth response protein 1		Transcription Factor Info
Tissue	Bone marrow; Breast; Colon; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Early growth response protein 1 (EGR1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
GLI2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Zinc finger protein GLI2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein GLI2 (GLI2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
KLF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Krueppel-like factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 1 (KLF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
KLF5		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in gastric cancer condition			[23]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of ABCC3 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[1]
TF Protein Name	Krueppel-like factor 5		Transcription Factor Info
Tissue	Colon; Pancreatic ductal; Stomach
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 5 (KLF5) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
KLF9		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Krueppel-like factor 9		Transcription Factor Info
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Krueppel-like factor 9 (KLF9) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Cervix; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
SP1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in cholestatic condition			[24]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor Sp1 (SP1) has been reported to bind to the transcription of ABCC3 gene in cholestatic condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Activation of ABCC3 gene in hepatoblastoma condition			[19]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	Up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of ABCC3 gene in hepatoblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
VEZF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Vascular endothelial zinc finger 1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
WT1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in podocyte condition			[25]
TF Protein Name	Wilms tumor protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Wilms tumor protein (WT1) has been reported to activate the transcription of ABCC3 gene in podocyte condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
ZBTB7A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Zinc finger and BTB domain-containing protein 7A		Transcription Factor Info
Tissue	Bone marrow; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ZNF217		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in breast cancer condition			[26]
TF Protein Name	Zinc finger protein 217		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of ABCC3 gene in breast cancer condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
ZNF263		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Zinc finger protein 263		Transcription Factor Info
Tissue	Bone marrow; Kidney
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 263 (ZNF263) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ZNF384		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Zinc finger protein 384		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Zinc finger protein 384 (ZNF384) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class2.6: CXXC zinc finger factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
KMT2B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Histone-lysine N-methyltransferase 2B		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Histone-lysine N-methyltransferase 2B (KMT2B) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 4 TF(s) Regulating This DT
CDX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene in health condition			[27]
TF Protein Name	Homeobox protein CDX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein CDX-2 (CDX2) has been reported to bind to the transcription of ABCC3 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
PBX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Pre-B-cell leukemia transcription factor 3		Transcription Factor Info
Tissue	Blood; Brain; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Pre-B-cell leukemia transcription factor 3 (PBX3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
POU2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	POU domain, class 2, transcription factor 1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	POU domain, class 2, transcription factor 1 (POU2F1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
SIX5		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Homeobox protein SIX5		Transcription Factor Info
Tissue	Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Homeobox protein SIX5 (SIX5) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 8 TF(s) Regulating This DT
E2F1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcription factor E2F1		Transcription Factor Info
Tissue	Breast; Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F1 (E2F1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
E2F6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Transcription factor E2F6		Transcription Factor Info
Tissue	Bone marrow; Embryo; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor E2F6 (E2F6) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXA1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Hepatocyte nuclear factor 3-alpha		Transcription Factor Info
Tissue	Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXA2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in health condition			[11]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ABCC3 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Direct binding to ABCC3 gene			[3]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXG1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Forkhead box protein G1		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein G1 (FOXG1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXM1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Forkhead box protein M1		Transcription Factor Info
Tissue	Brain; Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein M1 (FOXM1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXO3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Forkhead box protein O3		Transcription Factor Info
Tissue	Bone marrow; Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein O3 (FOXO3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FOXP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Forkhead box protein P1		Transcription Factor Info
Tissue	Colon; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Forkhead box protein P1 (FOXP1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 12 TF(s) Regulating This DT
ELF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	ETS-related transcription factor Elf-1		Transcription Factor Info
Tissue	Blood; Bone marrow; Breast; Liver; Lung; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS-related transcription factor Elf-1 (ELF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ELK1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[28]
TF Protein Name	ETS domain-containing protein Elk-1		Transcription Factor Info
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of ABCC3 gene, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
ELK3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in hypoxia condition			[29]
TF Protein Name	ETS domain-containing protein Elk-3		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	ETS domain-containing protein Elk-3 (ELK3) has been reported to bind to the transcription of ABCC3 gene in hypoxia condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
ELK4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	ETS domain-containing protein Elk-4		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS domain-containing protein Elk-4 (ELK4) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ERG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Transcriptional regulator ERG		Transcription Factor Info
Tissue	Aorta
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcriptional regulator ERG (ERG) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ETS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Protein C-ets-1		Transcription Factor Info
Tissue	Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-1 (ETS1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ETS2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Protein C-ets-2		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Protein C-ets-2 (ETS2) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ETV1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	ETS translocation variant 1		Transcription Factor Info
Tissue	Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	ETS translocation variant 1 (ETV1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
ETV7		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Transcription factor ETV7		Transcription Factor Info
Tissue	Colon
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor ETV7 (ETV7) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Bone marrow; Breast; Cervix; Embryo; Liver; Lung; Mesenchymal; Prostate
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class3.7: ARID domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
ARID3A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	AT-rich interactive domain-containing protein 3A		Transcription Factor Info
Tissue	Liver
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
KDM5B		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Lysine-specific demethylase 5B		Transcription Factor Info
Tissue	Breast
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Lysine-specific demethylase 5B (KDM5B) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in colorectal cancer condition			[30]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of ABCC3 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Transcriptional Phenomenon2	Activation of ABCC3 gene in glioblastoma condition			[31]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	Glioblastoma [ICD11: 2A00.00]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Human glioblastoma cells (A172)
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of ABCC3 gene in glioblastoma condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
Class4.2: Heteromeric CCAAT-binding factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
NFYA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[4]
TF Protein Name	Nuclear transcription factor Y subunit alpha		Transcription Factor Info
Tissue	Bone marrow
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear transcription factor Y subunit alpha (NFYA) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
EBF1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Transcription factor COE1		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor COE1 (EBF1) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCC3 gene in health condition			[32]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCC3 gene in health condition, which leads to an affected expression of the drug transporter Multidrug resistance-associated protein 3.
Class6.4: Runt domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
RUNX3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[3]
TF Protein Name	Runt-related transcription factor 3		Transcription Factor Info
Tissue	Blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Runt-related transcription factor 3 (RUNX3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
Class6.7: Grainyhead domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GRHL3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[1]
TF Protein Name	Grainyhead-like protein 3 homolog		Transcription Factor Info
Tissue	Skin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Grainyhead-like protein 3 homolog (GRHL3) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold
Class7.1: SMAD/NF-1 DNA-binding domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFIC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	Nuclear factor 1 C-type		Transcription Factor Info
Tissue	Brain; Liver; Uterus
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Nuclear factor 1 C-type (NFIC) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.
SMAD4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCC3 gene in hESCs condition			[33]
TF Protein Name	Mothers against decapentaplegic homolog 4		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of ABCC3 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Multidrug resistance-associated protein 3.
TF Superclass10: Yet undefined DNA-binding domains
Class10.5: GTF2I domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
GTF2I		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCC3 gene			[5]
TF Protein Name	General transcription factor II-I		Transcription Factor Info
Tissue	Foreskin
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	General transcription factor II-I (GTF2I) can directly bind to the ABCC3 gene, which in turn affects the expression or function of the drug transporter Multidrug resistance-associated protein 3.

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