Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0007 Transporter Info
Gene Name SLC47A1
Transporter Name Multidrug and toxin extrusion protein 1
Gene ID
55244
UniProt ID
Q96FL8

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 6 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC47A1 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLC47A1 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Multidrug and toxin extrusion protein 1.

        CEBPA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [2]

TF Protein Name

 CCAAT/enhancer-binding protein alpha Transcription Factor Info

Tissue

 Blood; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [3]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Bone

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        CREB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [4]

TF Protein Name

 Cyclic AMP-responsive element-binding protein 1 Transcription Factor Info

Tissue

 Bone marrow; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        JUN 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC47A1 gene in papillary renal cell cancer condition [5]

TF Protein Name

 Transcription factor Jun Transcription Factor Info

Studied Phenotype

 Papillary renal cell cancer [ICD11: 2C90.Y]

Tissue

 Kidney

Related DT Changes

 Up regulating

Experimental Material

 human kidney cell isolates

Detailed Description

 Transcription factor Jun (JUN) has been reported to activate the transcription of SLC47A1 gene in papillary renal cell cancer condition, which leads to an increased expression of the drug transporter Multidrug and toxin extrusion protein 1.

        NFE2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [6]

TF Protein Name

 Transcription factor NF-E2 45 kDa subunit Transcription Factor Info

Tissue

 Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor NF-E2 45 kDa subunit (NFE2) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in glioblastoma multiforme condition [7]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to bind to the transcription of SLC47A1 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in prostate cancer condition [8]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC47A1 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

        ESR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [3]

TF Protein Name

 Estrogen receptor Transcription Factor Info

Tissue

 Bone; Breast; Endometrium; Uterus

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Estrogen receptor (ESR1) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLC47A1 gene in health condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

        NR2F2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [2]

TF Protein Name

 COUP transcription factor 2 Transcription Factor Info

Tissue

 Breast; Liver

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 COUP transcription factor 2 (NR2F2) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        GATA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in megakaryocytes condition [10]

TF Protein Name

 Erythroid transcription factor Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Erythroid transcription factor (GATA1) has been reported to bind to the transcription of SLC47A1 gene in megakaryocytes condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

      Class2.3: C2H2 zinc finger factors

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        KLF12 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLC47A1 gene in papillary renal cell cancer condition [5]

TF Protein Name

 Krueppel-like factor 12 Transcription Factor Info

Studied Phenotype

 Papillary renal cell cancer [ICD11: 2C90.Y]

Tissue

 Kidney

Related DT Changes

 Down regulating

Experimental Material

 human kidney cell isolates

Detailed Description

 Krueppel-like factor 12 (KLF12) has been reported to repress the transcription of SLC47A1 gene in papillary renal cell cancer condition, which leads to a decreased expression of the drug transporter Multidrug and toxin extrusion protein 1.

        KLF9 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [6]

TF Protein Name

 Krueppel-like factor 9 Transcription Factor Info

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Krueppel-like factor 9 (KLF9) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        MAZ 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [4]

TF Protein Name

 Myc-associated zinc finger protein Transcription Factor Info

Tissue

 Blood; Liver; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myc-associated zinc finger protein (MAZ) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [3]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in health condition [9]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLC47A1 gene in health condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

      Class3.5: Tryptophan cluster factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        ETV1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [2]

TF Protein Name

 ETS translocation variant 1 Transcription Factor Info

Tissue

 GastroIntestine tract

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 ETS translocation variant 1 (ETV1) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

        SPI1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [4]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

      Class3.7: ARID domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        KDM5B 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [3]

TF Protein Name

 Lysine-specific demethylase 5B Transcription Factor Info

Tissue

 Breast

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Lysine-specific demethylase 5B (KDM5B) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

TF Superclass5: alpha-Helices exposed by beta-structures

      Class5.1: MADS box factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        MEF2A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [6]

TF Protein Name

 Myocyte-specific enhancer factor 2A Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Myocyte-specific enhancer factor 2A (MEF2A) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

TF Superclass6: Immunoglobulin fold

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [6]

TF Protein Name

 Signal transducer and activator of transcription 1-alpha/beta Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Signal transducer and activator of transcription 1-alpha/beta (STAT1) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

      Class6.3: p53 domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TP63 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene in epithelial to mesenchymal transition condition [11]

TF Protein Name

 Tumor protein 63 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Tumor protein 63 (TP63) has been reported to bind to the transcription of SLC47A1 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 3 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC47A1 gene [12]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLC47A1 gene in . condition, which leads to an affected expression of the drug transporter Multidrug and toxin extrusion protein 1.

        RUNX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC47A1 gene in prostate cancer condition [13]

TF Protein Name

 Runt-related transcription factor 2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of SLC47A1 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Multidrug and toxin extrusion protein 1.

        RUNX3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC47A1 gene [2]

TF Protein Name

 Runt-related transcription factor 3 Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Runt-related transcription factor 3 (RUNX3) can directly bind to the SLC47A1 gene, which in turn affects the expression or function of the drug transporter Multidrug and toxin extrusion protein 1.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC47A1 gene in human embryonic stem cells condition [14]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC47A1 gene in human embryonic stem cells (hESCs) condition, which leads to an increased expression of the drug transporter Multidrug and toxin extrusion protein 1.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
3 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
4 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
5 Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct;19(10):770-80.
6 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-304. (ID:ENSG00000142494)
7 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
8 Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009;4(8):e6589.
9 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
10 Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators. Dev Cell. 2011;20(5):597-609.
11 p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.
12 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.
13 Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012;40(8):3538-47.
14 Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs. Dev Biol. 2011;357(2):492-504.

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