Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID	DTD0004 Transporter Info
Gene Name	ABCG2
Transporter Name	Breast cancer resistance protein
Gene ID	9429
UniProt ID	Q9UNQ0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains
Class1.1: Basic leucine zipper factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
FOSL2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[1]
TF Protein Name	Fos-related antigen 2		Transcription Factor Info
Tissue	Breast; Liver; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Fos-related antigen 2 (FOSL2) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
JUND		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in coronary artery disease condition			[2]
TF Protein Name	Transcription factor JunD		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Transcription factor JunD (JUND) has been reported to bind to the transcription of ABCG2 gene in coronary artery disease condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
NFE2L2		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in non-small cell lung cancer condition			[3]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone; Topotecan
Studied Phenotype	Non-small cell lung cancer [ICD11: 2C25.Y]
Tissue	Lung
Related DT Changes	Up regulating
Experimental Material	Human lung adenocarcinoma cells (A549)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2) has been reported to activate the transcription of ABCG2 gene in non-small cell lung cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in hepatoblastoma condition			[4]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Hepatoblastoma [ICD11: 2C12.01]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatoblastoma cells (HepG2)
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous bisphenol A, has been reported to activate the transcription of ABCG2 gene in hepatoblastoma condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon3	Activation of ABCG2 gene in health condition			[5]
TF Protein Name	Nuclear factor erythroid 2-related factor 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human fetal liver samples
Detailed Description	Nuclear factor erythroid 2-related factor 2 (NFE2L2), influenced by the exogenous bisphenol A, has been reported to activate the transcription of ABCG2 gene in health condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Class1.2: Basic helix-loop-helix factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
AHR		Click to Show/Hide to Show 4 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in colon cancer condition			[6], [7]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone; Benzo[a]pyrene-3-sulfate
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	Up regulating
Experimental Material	C57BL/6N mice
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCG2 gene in colon cancer condition, which leads to an enhanced function of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in health condition			[6]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Aryl hydrocarbon receptor (AHR) has been reported to activate the transcription of ABCG2 gene in health condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon3	Activation of ABCG2 gene in colon cancer condition			[8]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	up regulating
Experimental Material	Human colon adenocarcinoma cells (Caco-2)
Detailed Description	Aryl hydrocarbon receptor (AHR), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to activate the transcription of ABCG2 gene in colon cancer condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon4	Activation of ABCG2 gene in health condition			[9]
TF Protein Name	Aryl hydrocarbon receptor		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Placenta
Related DT Changes	up regulating
Experimental Material	Human placental trophoblast cells (TR-S)
Detailed Description	Aryl hydrocarbon receptor (AHR), influenced by the exogenous polychlorinated dibenzodioxin, has been reported to activate the transcription of ABCG2 gene in health condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
EPAS1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[10]
TF Protein Name	Endothelial PAS domain-containing protein 1		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Heart
Related DT Changes	up regulating
Experimental Material	Human cardiac side population cells
Detailed Description	Endothelial PAS domain-containing protein 1 (EPAS1), influenced by the exogenous hydrogen Peroxide, has been reported to activate the transcription of ABCG2 gene in health condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
MYC		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in AK7 condition			[11]
TF Protein Name	Myc proto-oncogene protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Myc proto-oncogene protein (MYC) has been reported to bind to the transcription of ABCG2 gene in AK7 condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
Class1.3: Basic helix-span-helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TFAP2A		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[12]
TF Protein Name	Transcription factor AP-2-alpha		Transcription Factor Info
Tissue	Cervix
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor AP-2-alpha (TFAP2A) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
TF Superclass2: Zinc-coordinating DNA-binding domains
Class2.1: Nuclear receptors with C4 zinc fingers		Click to Show/Hide the Full List of 10 TF(s) Regulating This DT
AR		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Repression of ABCG2 gene in prostate cancer condition			[13]
TF Protein Name	Androgen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Androgen receptor (AR) has been reported to repress the transcription of ABCG2 gene in prostate cancer condition, which leads to a decreased expression of the drug transporter Breast cancer resistance protein.
ESR1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in breast cancer condition			[14]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Estrogen receptor (ESR1) has been reported to bind to the ABCG2 gene in breast cancer condition, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in bone homeostasis condition			[15]
TF Protein Name	Estrogen receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Estrogen receptor (ESR1) has been reported to activate the transcription of ABCG2 gene in bone homeostasis condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
HNF4A		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in health condition			[16]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCG2 gene in health condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Binding to ABCG2 gene in health condition			[17]
TF Protein Name	Hepatocyte nuclear factor 4-alpha		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ABCG2 gene in health condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
NR1H4		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in colorectal cancer condition			[18]
TF Protein Name	Bile acid receptor		Transcription Factor Info
Studied Phenotype	Colorectal cancer [ICD11: 2B91]
Tissue	Colon
Related DT Changes	up regulating
Experimental Material	human colorectal adenocarcinoma cells (LS174T)
Detailed Description	Bile acid receptor (NR1H4), influenced by the exogenous cisplatin, has been reported to activate the transcription of ABCG2 gene in colorectal cancer condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
NR1I2		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[19]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatocytes
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the exogenous rifampin, has been reported to activate the transcription of ABCG2 gene in health condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Repression of ABCG2 gene in breast cancer condition			[20]
TF Protein Name	Nuclear receptor subfamily 1 group I member 2		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Down regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to repress the transcription of ABCG2 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Breast cancer resistance protein.
NR1I3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[21]
TF Protein Name	Nuclear receptor subfamily 1 group I member 3		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Liver
Related DT Changes	up regulating
Experimental Material	Human hepatocytes
Detailed Description	Nuclear receptor subfamily 1 group I member 3 (NR1I3), influenced by the exogenous phenobarbital, has been reported to activate the transcription of ABCG2 gene in health condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
NR3C1		Click to Show/Hide to Show 3 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in ER(-) breast cancer condition			[22]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of ABCG2 gene in ER(-) breast cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in brain edema condition			[23]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Studied Phenotype	Brain edema [ICD11: 8D60.1]
Tissue	Brain
Related DT Changes	Up regulating
Experimental Material	Sprague-Dawley rats
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to activate the transcription of ABCG2 gene in brain edema condition, which leads to an enhanced function of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon3	Repression of ABCG2 gene in breast cancer condition			[20]
TF Protein Name	Glucocorticoid receptor		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Down regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Glucocorticoid receptor (NR3C1) has been reported to repress the transcription of ABCG2 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Breast cancer resistance protein.
PGR		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in breast cancer condition			[20]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone
Studied Phenotype	Breast cancer [ICD11: 2C60-2C6Z]
Tissue	Breast
Related DT Changes	Up regulating
Experimental Material	Human invasive breast carcinoma of no special type cells (MCF-7)
Detailed Description	Progesterone receptor (PGR) has been reported to activate the transcription of ABCG2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Repression of ABCG2 gene in breast cancer condition			[24]
TF Protein Name	Progesterone receptor		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Down regulating
Detailed Description	Progesterone receptor (PGR) has been reported to repress the transcription of ABCG2 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Breast cancer resistance protein.
PPARA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[25]
TF Protein Name	Peroxisome proliferator-activated receptor alpha		Transcription Factor Info
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Intestine
Related DT Changes	Up regulating
Experimental Material	C57BL/6 mice
Detailed Description	Peroxisome proliferator-activated receptor alpha (PPARA) has been reported to activate the transcription of ABCG2 gene in health condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
PPARG		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[26]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Affected Drug/Substrate	Mitoxantrone
Studied Phenotype	Heallth [ICD11: N.A]
Tissue	Kidney
Related DT Changes	Up regulating
Experimental Material	Green monkey Kidney fibroblast-like cells (COS-1)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG) has been reported to activate the transcription of ABCG2 gene in health condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in colon cancer condition			[27]
TF Protein Name	Peroxisome proliferator-activated receptor gamma		Transcription Factor Info
Studied Phenotype	Colon cancer [ICD11: 2B90]
Tissue	Colon
Related DT Changes	up regulating
Experimental Material	Human colon adenocarcinoma cells (Caco-2)
Detailed Description	Peroxisome proliferator-activated receptor gamma (PPARG), influenced by the exogenous troglitazone, has been reported to activate the transcription of ABCG2 gene in colon cancer condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Class2.3: C2H2 zinc finger factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
BCL6		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in health condition			[28]
TF Protein Name	B-cell lymphoma 6 protein		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	B-cell lymphoma 6 protein (BCL6) has been reported to activate the transcription of ABCG2 gene in health condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
MAZ		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[1]
TF Protein Name	Myc-associated zinc finger protein		Transcription Factor Info
Tissue	Blood; Bone marrow; Lung
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Myc-associated zinc finger protein (MAZ) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
SP1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in pancreatic cancer condition			[29]
TF Protein Name	Transcription factor Sp1		Transcription Factor Info
Affected Drug/Substrate	Gemcitabine; 5-fluorouracil
Studied Phenotype	Pancreatic cancer [ICD11: 2C10]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	Human pancreatic ductal adenocarcinoma cells (ASPC-1)
Detailed Description	Transcription factor Sp1 (SP1) has been reported to activate the transcription of ABCG2 gene in pancreatic cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
TF Superclass3: Helix-turn-helix domains
Class3.1: Homeo domain factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
MSX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in pancreatic cancer condition			[29]
TF Protein Name	Homeobox protein MSX-2		Transcription Factor Info
Affected Drug/Substrate	Gemcitabine; 5-fluorouracil
Studied Phenotype	Pancreatic cancer [ICD11: 2C10]
Tissue	Pancreas
Related DT Changes	Up regulating
Experimental Material	Human pancreatic ductal adenocarcinoma cells (ASPC-1)
Detailed Description	Homeobox protein MSX-2 (MSX2) has been reported to activate the transcription of ABCG2 gene in pancreatic cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
NANOG		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in health condition			[30]
TF Protein Name	Homeobox protein NANOG		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of ABCG2 gene in health condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
Class3.3: Fork head / winged helix factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
FOXA2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in health condition			[17]
TF Protein Name	Hepatocyte nuclear factor 3-beta		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ABCG2 gene in health condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.
Class3.5: Tryptophan cluster factors		Click to Show/Hide the Full List of 3 TF(s) Regulating This DT
FLI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[31]
TF Protein Name	Friend leukemia integration 1 transcription factor		Transcription Factor Info
Tissue	Blood; Mesenchymal; Vein
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
GABPA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[32]
TF Protein Name	GA-binding protein alpha chain		Transcription Factor Info
Tissue	Blood; Liver; Lung; Mesenchymal
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	GA-binding protein alpha chain (GABPA) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
SPI1		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Direct binding to ABCG2 gene			[12]
TF Protein Name	Transcription factor PU.1		Transcription Factor Info
Tissue	Adrenal gland; Blood; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood
Related DT Changes	Direct regulating
Experiment method	TF-transporter regulations were collected from ChIP-Seq datasets.
Detailed Description	Transcription factor PU.1 (SPI1) can directly bind to the ABCG2 gene, which in turn affects the expression or function of the drug transporter Breast cancer resistance protein.
TF Superclass4: Other all-alpha-helical DNA-binding domains
Class4.1: High-mobility group domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
SOX2		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in colorectal cancer condition			[33]
TF Protein Name	Transcription factor SOX-2		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor SOX-2 (SOX2) has been reported to activate the transcription of ABCG2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
TF Superclass6: Immunoglobulin fold
Class6.1: Rel homology region factors		Click to Show/Hide the Full List of 2 TF(s) Regulating This DT
NFKB1		Click to Show/Hide to Show 2 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in bone homeostasis condition			[15]
TF Protein Name	Nuclear factor NF-kappa-B p105 subunit		Transcription Factor Info
Affected Drug/Substrate	17beta-estradiol
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to activate the transcription of ABCG2 gene in bone homeostasis condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Transcriptional Phenomenon2	Activation of ABCG2 gene in lung adenocarcinoma condition			[34]
TF Protein Name	Nuclear factor NF-kappa-B p105 subunit		Transcription Factor Info
Studied Phenotype	Lung adenocarcinoma [ICD11: 2C25.0]
Tissue	Lung
Related DT Changes	up regulating
Experimental Material	Human lung adenocarcinoma cells (A549)
Detailed Description	Nuclear factor NF-kappa-B p105 subunit (NFKB1), influenced by the exogenous arsenic trioxide, has been reported to activate the transcription of ABCG2 gene in lung adenocarcinoma condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
RELA		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in bone homeostasis condition			[15]
TF Protein Name	Transcription factor p65		Transcription Factor Info
Affected Drug/Substrate	17beta-estradiol
Studied Phenotype	.
Related DT Changes	Up regulating
Detailed Description	Transcription factor p65 (RELA) has been reported to activate the transcription of ABCG2 gene in bone homeostasis condition, which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Class6.2: STAT domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
STAT3		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Activation of ABCG2 gene in epithelial ovarian cancer condition			[35]
TF Protein Name	Signal transducer and activator of transcription 3		Transcription Factor Info
Affected Drug/Substrate	Doxorubicin
Studied Phenotype	Epithelial ovarian cancer [2B5D.0]
Tissue	Ovary
Related DT Changes	up regulating
Experimental Material	Human doxorubicin-resistant epithelial ovarian cancer cells (A2780-R)
Detailed Description	Signal transducer and activator of transcription 3 (STAT3), influenced by the exogenous paclitaxel, has been reported to activate the transcription of ABCG2 gene in epithelial ovarian cancer condition , which leads to an increased expression of the drug transporter Breast cancer resistance protein.
Class6.3: p53 domain factors		Click to Show/Hide the Full List of 1 TF(s) Regulating This DT
TP63		Click to Show/Hide to Show 1 Transcriptional Phenomena
Transcriptional Phenomenon1	Binding to ABCG2 gene in epithelial to mesenchymal transition condition			[36]
TF Protein Name	Tumor protein 63		Transcription Factor Info
Studied Phenotype	.
Related DT Changes	Direct regulating
Detailed Description	Tumor protein 63 (TP63) has been reported to bind to the transcription of ABCG2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Breast cancer resistance protein.

References
1	NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2	Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci. PLoS Genet. 2015;11(5):e1005202.
3	Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype. Mol Cancer Ther. 2010 Aug;9(8):2365-76.
4	Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol. 2007;6(4):335-48.
5	Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers. Drug Metab Dispos. 2016 Jul;44(7):1061-5.
6	Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2). Mol Pharmacol. 2010 Aug;78(2):175-85.
7	Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis. 2005 Oct;26(10):1754-63.
8	Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007 Apr;96(2):227-36.
9	Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures. Toxicol Sci. 2011 Sep;123(1):26-36.
10	Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res. 2008 May 9;102(9):1075-81.
11	Gene regulation and epigenetic remodeling in murine embryonic stem cells by c-Myc. PLoS One. 2009;4(11):e7839.
12	hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-239. (ID:ENSG00000118777)
13	Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
14	Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic Acids Res. 2004;32(22):6627-35.
15	Suppression of ligand-dependent estrogen receptor activity by bone-resorbing cytokines in human osteoblasts. Endocrinology. 1999;140(6):2439-51.
16	Mapping of HNF4alpha target genes in intestinal epithelial cells. BMC Gastroenterol. 2009;9:68.
17	Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
18	Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins. Mol Pharm. 2012 Sep 4;9(9):2565-76.
19	Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63.
20	Dexamethasone down-regulates ABCG2 expression levels in breast cancer cells. Biochem Biophys Res Commun. 2008 Oct 24;375(3):308-14.
21	Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes. Arch Biochem Biophys. 2012 Jan 15;517(2):123-30.
22	Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res. 2011;71(20):6360-70.
23	Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. Am J Physiol Cell Physiol. 2008 Aug;295(2):C440-50.
24	Progesterone receptor downregulates breast cancer resistance protein expression via binding to the progesterone response element in breast cancer. Cancer Sci. 2012 May;103(5):959-67.
25	PPARalpha agonists positively and negatively regulate the expression of several nutrient/drug transporters in mouse small intestine. Biol Pharm Bull. 2007 Nov;30(11):2185-90.
26	Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. J Biol Chem. 2006 Aug 18;281(33):23812-23.
27	Short-chain fatty acids exert opposite effects on the expression and function of p-glycoprotein and breast cancer resistance protein in rat intestine. Acta Pharmacol Sin. 2021 Mar;42(3):470-481.
28	The transcriptional regulator BCL6 participates in the secondary gene regulatory response to vitamin D. Biochim Biophys Acta. 2015;1849(3):300-8.
29	The homeobox gene MSX2 determines chemosensitivity of pancreatic cancer cells via the regulation of transporter gene ABCG2. J Cell Physiol. 2012 Feb;227(2):729-38.
30	Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
31	Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
32	The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
33	ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. OMICS. 2010;14(4):369-84.
34	Regulation of ABCG2 by nuclear factor kappa B affects the sensitivity of human lung adenocarcinoma A549 cells to arsenic trioxide. Environ Toxicol Pharmacol. 2018 Jan;57:141-150.
35	CD109 Promotes Drug Resistance in A2780 Ovarian Cancer Cells by Regulating the STAT3-NOTCH1 Signaling Axis. Int J Mol Sci. 2023 Jun 18;24(12):10306.
36	p63 attenuates epithelial to mesenchymal potential in an experimental prostate cell model. PLoS One. 2013;8(5):e62547.

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