Detail Information of Transcriptional Regulations
General Information of Drug Transporter (DT) | |||||
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DT ID | DTD0542 Transporter Info | ||||
Gene Name | ANXA2 | ||||
Transporter Name | Annexin A2 | ||||
Gene ID | |||||
UniProt ID | |||||
Transcriptional Regulation of This DT (TSR) | ||||||
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Class1.1: Basic leucine zipper factors |
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ATF3 |
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Transcriptional Phenomenon1 |
Repression of ANXA2 gene in glioblastoma multiforme condition | [1] | ||||
TF Protein Name |
Cyclic AMP-dependent transcription factor ATF-3 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) has been reported to repress the transcription of ANXA2 gene in glioblastoma multiforme condition, which leads to a decreased expression of the drug transporter Annexin A2. | |||||
CEBPA |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein alpha (CEBPA) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
CEBPD |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
CCAAT/enhancer-binding protein delta | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
CCAAT/enhancer-binding protein delta (CEBPD) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
CREB1 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Cyclic AMP-responsive element-binding protein 1 | Transcription Factor Info | ||||
Tissue |
Breast; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Cyclic AMP-responsive element-binding protein 1 (CREB1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FOSL1 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Fos-related antigen 1 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast; Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Fos-related antigen 1 (FOSL1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FOSL2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Fos-related antigen 2 | Transcription Factor Info | ||||
Tissue |
Brain; Breast; Liver; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Fos-related antigen 2 (FOSL2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
JUN |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene in coronary artery disease condition | [6] | ||||
TF Protein Name |
Transcription factor Jun | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor Jun (JUN) has been reported to bind to the ANXA2 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Annexin A2. | |||||
JUNB |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Transcription factor JunB | Transcription Factor Info | ||||
Tissue |
Aorta | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor JunB (JUNB) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
JUND |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcription factor JunD | Transcription Factor Info | ||||
Tissue |
Bone | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor JunD (JUND) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class1.2: Basic helix-loop-helix factors |
Click to Show/Hide the Full List of 10 TF(s) Regulating This DT |
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ARNT |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Aryl hydrocarbon receptor nuclear translocator | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Aryl hydrocarbon receptor nuclear translocator (ARNT) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ASCL1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Achaete-scute homolog 1 | Transcription Factor Info | ||||
Tissue |
Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Achaete-scute homolog 1 (ASCL1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ASCL2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Achaete-scute homolog 2 | Transcription Factor Info | ||||
Tissue |
Colon; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Achaete-scute homolog 2 (ASCL2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
CLOCK |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in microsatellite unstable colorectal cancers condition | [7] | ||||
TF Protein Name |
Circadian locomoter output cycles protein kaput | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Circadian locomoter output cycles protein kaput (CLOCK) has been reported to activate the transcription of ANXA2 gene in microsatellite unstable colorectal cancers condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
MITF |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in melanoma condition | [8] | ||||
TF Protein Name |
Microphthalmia-associated transcription factor | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Microphthalmia-associated transcription factor (MITF) has been reported to activate the transcription of ANXA2 gene in melanoma condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
MYOD1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Myoblast determination protein 1 | Transcription Factor Info | ||||
Tissue |
Myotube | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myoblast determination protein 1 (MYOD1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TCF12 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Transcription factor 12 | Transcription Factor Info | ||||
Tissue |
Blood; Brain; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 12 (TCF12) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TCF21 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in coronary artery disease condition | [6] | ||||
TF Protein Name |
Transcription factor 21 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor 21 (TCF21) has been reported to bind to the ANXA2 gene in coronary artery disease condition, which affects the expression or function of the drug transporter Annexin A2. | |||||
Transcriptional Phenomenon2 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcription factor 21 | Transcription Factor Info | ||||
Tissue |
Coronary artery | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor 21 (TCF21) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TCF3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Transcription factor E2-alpha | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2-alpha (TCF3) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TCF4 |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in glioblastoma multiforme condition | [9] | ||||
TF Protein Name |
Transcription factor 4 | Transcription Factor Info | ||||
Affected Drug/Substrate |
Temozolomide | |||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor 4 (TCF4) has been reported to bind to the transcription of ANXA2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Class1.3: Basic helix-span-helix factors |
Click to Show/Hide the Full List of 2 TF(s) Regulating This DT |
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TFAP2A |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Transcription factor AP-2-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2-alpha (TFAP2A) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TFAP2C |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcription factor AP-2 gamma | Transcription Factor Info | ||||
Tissue |
Breast; Cervix; Skin | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor AP-2 gamma (TFAP2C) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class2.1: Nuclear receptors with C4 zinc fingers |
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AR |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene | [10] | ||||
TF Protein Name |
Androgen receptor | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Androgen receptor (AR) has been reported to bind to the transcription of ANXA2 gene in . condition, which leads to a affected expression of the drug transporter Annexin A2. | |||||
ESR1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Estrogen receptor | Transcription Factor Info | ||||
Tissue |
Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Estrogen receptor (ESR1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
HNF4A |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in health condition | [11] | ||||
TF Protein Name |
Hepatocyte nuclear factor 4-alpha | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of ANXA2 gene in health condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
NR2F2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
COUP transcription factor 2 | Transcription Factor Info | ||||
Tissue |
Breast; Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
COUP transcription factor 2 (NR2F2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
PGR |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Progesterone receptor | Transcription Factor Info | ||||
Tissue |
Breast; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Progesterone receptor (PGR) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
PPARD |
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Transcriptional Phenomenon1 |
Repression of ANXA2 gene in myofibroblast condition | [12] | ||||
TF Protein Name |
Peroxisome proliferator-activated receptor delta | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Down regulating | |||||
Detailed Description |
Peroxisome proliferator-activated receptor delta (PPARD) has been reported to repress the transcription of ANXA2 gene in myofibroblast condition, which leads to a decreased expression of the drug transporter Annexin A2. | |||||
Class2.2: Other C4 zinc finger-type factors |
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GATA1 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Erythroid transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Erythroid transcription factor (GATA1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
GATA3 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in breast cancer condition | [13] | ||||
TF Protein Name |
Trans-acting T-cell-specific transcription factor GATA-3 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) has been reported to bind to the transcription of ANXA2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Transcriptional Phenomenon2 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Trans-acting T-cell-specific transcription factor GATA-3 | Transcription Factor Info | ||||
Tissue |
Blood; Brain; Breast; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
GATA4 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in gastric cancer condition | [14] | ||||
TF Protein Name |
Transcription factor GATA-4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription factor GATA-4 (GATA4) has been reported to activate the transcription of ANXA2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
GATA6 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in gastric cancer condition | [14] | ||||
TF Protein Name |
Transcription factor GATA-6 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of ANXA2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
Class2.3: C2H2 zinc finger factors |
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KLF1 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Krueppel-like factor 1 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 1 (KLF1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
KLF5 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in gastric cancer condition | [14] | ||||
TF Protein Name |
Krueppel-like factor 5 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of ANXA2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
KLF9 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Krueppel-like factor 9 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Krueppel-like factor 9 (KLF9) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
MAZ |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Myc-associated zinc finger protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Myc-associated zinc finger protein (MAZ) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
MECOM |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Histone-lysine N-methyltransferase MECOM | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Histone-lysine N-methyltransferase MECOM (MECOM) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
VEZF1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Vascular endothelial zinc finger 1 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Vascular endothelial zinc finger 1 (VEZF1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ZBTB17 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Zinc finger and BTB domain-containing protein 17 | Transcription Factor Info | ||||
Tissue |
Bone | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger and BTB domain-containing protein 17 (ZBTB17) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ZNF217 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in breast cancer condition | [15] | ||||
TF Protein Name |
Zinc finger protein 217 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of ANXA2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
ZNF263 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Zinc finger protein 263 | Transcription Factor Info | ||||
Tissue |
Kidney | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger protein 263 (ZNF263) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class2.6: CXXC zinc finger factors |
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KMT2B |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Histone-lysine N-methyltransferase 2B | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Histone-lysine N-methyltransferase 2B (KMT2B) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class2.8: C3H zinc finger factors |
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ZC3H8 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Zinc finger CCCH domain-containing protein 8 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Zinc finger CCCH domain-containing protein 8 (ZC3H8) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.1: Homeo domain factors |
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HOXB13 |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Homeobox protein Hox-B13 | Transcription Factor Info | ||||
Tissue |
Colon; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Homeobox protein Hox-B13 (HOXB13) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
LHX2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
LIM/homeobox protein Lhx2 | Transcription Factor Info | ||||
Tissue |
Epithelium | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
LIM/homeobox protein Lhx2 (LHX2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
NKX2-1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Homeobox protein Nkx-2.1 | Transcription Factor Info | ||||
Tissue |
Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Homeobox protein Nkx-2.1 (NKX2-1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.2: Paired box factors |
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PAX6 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Paired box protein Pax-6 | Transcription Factor Info | ||||
Tissue |
Epithelium | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Paired box protein Pax-6 (PAX6) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.3: Fork head / winged helix factors |
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E2F1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcription factor E2F1 | Transcription Factor Info | ||||
Tissue |
Mesenchymal | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F1 (E2F1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
E2F4 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in health condition | [16] | ||||
TF Protein Name |
Transcription factor E2F4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Transcription factor E2F4 (E2F4) has been reported to bind to the transcription of ANXA2 gene in health condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
E2F6 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Transcription factor E2F6 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Embryo; Lung | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor E2F6 (E2F6) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FOXA1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-alpha | Transcription Factor Info | ||||
Tissue |
Breast; Embryo; Liver; Lung; Pancreatic ductal; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-alpha (FOXA1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FOXA2 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in health condition | [11] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-beta | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of ANXA2 gene in health condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Transcriptional Phenomenon2 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Hepatocyte nuclear factor 3-beta | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Hepatocyte nuclear factor 3-beta (FOXA2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FOXM1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in breast cancer condition | [17] | ||||
TF Protein Name |
Forkhead box protein M1 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Forkhead box protein M1 (FOXM1) has been reported to activate the transcription of ANXA2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
FOXO3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Forkhead box protein O3 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Forkhead box protein O3 (FOXO3) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.5: Tryptophan cluster factors |
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ELK1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in . condition | [18] | ||||
TF Protein Name |
ETS domain-containing protein Elk-1 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
ETS domain-containing protein Elk-1 (ELK1) has been reported to bind to the transcription of ANXA2 gene in . condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
ERG |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Repression of ANXA2 gene in prostate cancer condition | [19] | ||||
TF Protein Name |
Transcriptional regulator ERG | Transcription Factor Info | ||||
Studied Phenotype |
Prostate cancer [ICD11: 2C82] | |||||
Tissue |
Prostate | |||||
Related DT Changes |
Down regulating | |||||
Experimental Material |
Human prostate carcinoma cells (VCaP) | |||||
Detailed Description |
Transcriptional regulator ERG (ERG) has been reported to repress the transcription of ANXA2 gene in prostate cancer condition, which leads to a decreased expression of the drug transporter Annexin A2. | |||||
ETS1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Protein C-ets-1 | Transcription Factor Info | ||||
Tissue |
Blood; Bone; Bone marrow; Kidney; Lung; Prostate; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Protein C-ets-1 (ETS1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ETV7 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Transcription factor ETV7 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor ETV7 (ETV7) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
FLI1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Friend leukemia integration 1 transcription factor | Transcription Factor Info | ||||
Tissue |
Blood; Mesenchymal; Vein | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Friend leukemia integration 1 transcription factor (FLI1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
MYB |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Transcriptional activator Myb | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional activator Myb (MYB) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
SPI1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcription factor PU.1 | Transcription Factor Info | ||||
Tissue |
Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcription factor PU.1 (SPI1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.6: TEA domain factors |
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TEAD4 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
Transcriptional enhancer factor TEF-3 | Transcription Factor Info | ||||
Tissue |
Bone marrow; Brain; Breast; Colon; Embryo; Liver; Lung; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Transcriptional enhancer factor TEF-3 (TEAD4) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class3.7: ARID domain factors |
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ARID3A |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
AT-rich interactive domain-containing protein 3A | Transcription Factor Info | ||||
Tissue |
Liver | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
AT-rich interactive domain-containing protein 3A (ARID3A) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
KDM5B |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Lysine-specific demethylase 5B | Transcription Factor Info | ||||
Tissue |
Bone marrow; Breast | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Lysine-specific demethylase 5B (KDM5B) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class6.2: STAT domain factors |
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STAT3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in non-alcoholic steatohepatitis condition | [20] | ||||
TF Protein Name |
Signal transducer and activator of transcription 3 | Transcription Factor Info | ||||
Studied Phenotype |
Non-alcoholic steatohepatitis [ICD11: DB92.1] | |||||
Tissue |
Liver | |||||
Related DT Changes |
Up regulating | |||||
Experimental Material |
C57BL/6J mice | |||||
Detailed Description |
Signal transducer and activator of transcription 3 (STAT3) has been reported to activate the transcription of ANXA2 gene in non-alcoholic steatohepatitis condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
Class6.3: p53 domain factors |
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TP53 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in tumor condition | [21] | ||||
TF Protein Name |
Cellular tumor antigen p53 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Cellular tumor antigen p53 (TP53) has been reported to bind to the transcription of ANXA2 gene in tumor condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
TP63 |
Click to Show/Hide to Show 2 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in epithelial to mesenchymal transition condition | [22] | ||||
TF Protein Name |
Tumor protein 63 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Tumor protein 63 (TP63) has been reported to bind to the transcription of ANXA2 gene in epithelial to mesenchymal transition condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Transcriptional Phenomenon2 |
Binding to ANXA2 gene in health condition | [23] | ||||
TF Protein Name |
Tumor protein 63 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Tumor protein 63 (TP63) has been reported to bind to the transcription of ANXA2 gene in health condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Class6.4: Runt domain factors |
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RUNX2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Activation of ANXA2 gene in prostate cancer condition | [24] | ||||
TF Protein Name |
Runt-related transcription factor 2 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Up regulating | |||||
Detailed Description |
Runt-related transcription factor 2 (RUNX2) has been reported to activate the transcription of ANXA2 gene in prostate cancer condition, which leads to an increased expression of the drug transporter Annexin A2. | |||||
RUNX3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [5] | ||||
TF Protein Name |
Runt-related transcription factor 3 | Transcription Factor Info | ||||
Tissue |
Blood | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Runt-related transcription factor 3 (RUNX3) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class6.7: Grainyhead domain factors |
Click to Show/Hide the Full List of 1 TF(s) Regulating This DT |
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GRHL2 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [4] | ||||
TF Protein Name |
Grainyhead-like protein 2 homolog | Transcription Factor Info | ||||
Tissue |
Breast; Bronchus; Ovary; Prostate | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Grainyhead-like protein 2 homolog (GRHL2) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold |
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Class7.1: SMAD/NF-1 DNA-binding domain factors |
Click to Show/Hide the Full List of 3 TF(s) Regulating This DT |
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NFIC |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Nuclear factor 1 C-type | Transcription Factor Info | ||||
Tissue |
Brain; Liver; Uterus | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Nuclear factor 1 C-type (NFIC) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
SMAD3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in HaCaT keratinocytes condition | [25] | ||||
TF Protein Name |
Mothers against decapentaplegic homolog 3 | Transcription Factor Info | ||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Mothers against decapentaplegic homolog 3 (SMAD3) has been reported to bind to the transcription of ANXA2 gene in HaCaT keratinocytes condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
SMAD4 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Binding to ANXA2 gene in health condition | [26] | ||||
TF Protein Name |
Mothers against decapentaplegic homolog 4 | Transcription Factor Info | ||||
Studied Phenotype |
. | |||||
Related DT Changes |
Direct regulating | |||||
Detailed Description |
Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to bind to the transcription of ANXA2 gene in health condition, which leads to an affected expression of the drug transporter Annexin A2. | |||||
Class8.1: TATA-binding proteins |
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TBP |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
TATA-box-binding protein | Transcription Factor Info | ||||
Tissue |
Blood; Bone marrow; Cervix; Embryo | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
TATA-box-binding protein (TBP) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
Class10.1: Other factors |
Click to Show/Hide the Full List of 2 TF(s) Regulating This DT |
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REPIN1 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [2] | ||||
TF Protein Name |
Replication initiator 1 | Transcription Factor Info | ||||
Tissue |
Colon | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
Replication initiator 1 (REPIN1) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
ZZZ3 |
Click to Show/Hide to Show 1 Transcriptional Phenomena |
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Transcriptional Phenomenon1 |
Direct binding to ANXA2 gene | [3] | ||||
TF Protein Name |
ZZ-type zinc finger-containing protein 3 | Transcription Factor Info | ||||
Tissue |
Blood; Cervix | |||||
Related DT Changes |
Direct regulating | |||||
Experiment method |
TF-transporter regulations were collected from ChIP-Seq datasets. | |||||
Detailed Description |
ZZ-type zinc finger-containing protein 3 (ZZZ3) can directly bind to the ANXA2 gene, which in turn affects the expression or function of the drug transporter Annexin A2. | |||||
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