Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0482 Transporter Info
Gene Name SLC9A2
Transporter Name Sodium/hydrogen exchanger 2
Gene ID
6549
UniProt ID
Q9UBY0

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

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        CEBPB 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A2 gene [1]

TF Protein Name

 CCAAT/enhancer-binding protein beta Transcription Factor Info

Tissue

 Blood; Bone marrow; Breast; Cervix; Colon; Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 CCAAT/enhancer-binding protein beta (CEBPB) can directly bind to the SLC9A2 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 2.

      Class1.2: Basic helix-loop-helix factors

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        ASCL1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A2 gene [2]

TF Protein Name

 Achaete-scute homolog 1 Transcription Factor Info

Tissue

 Lung

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Achaete-scute homolog 1 (ASCL1) can directly bind to the SLC9A2 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 2.

        MYOD1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition [3]

TF Protein Name

 Myoblast determination protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Myoblast determination protein 1 (MYOD1) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        TCF3 

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       Transcriptional Phenomenon1

 Direct binding to SLC9A2 gene [4]

TF Protein Name

 Transcription factor E2-alpha Transcription Factor Info

Tissue

 Blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor E2-alpha (TCF3) can directly bind to the SLC9A2 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 2.

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A2 gene in colorectal cancer condition [5]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLC9A2 gene in colorectal cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

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        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in prostate cancer condition [6]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLC9A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        ESR2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in breast cancer condition [7]

TF Protein Name

 Estrogen receptor beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Estrogen receptor beta (ESR2) has been reported to bind to the transcription of SLC9A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

      Class2.2: Other C4 zinc finger-type factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        GATA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in hematopoiesis condition [8]

TF Protein Name

 Endothelial transcription factor GATA-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Endothelial transcription factor GATA-2 (GATA2) has been reported to bind to the transcription of SLC9A2 gene in hematopoiesis condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        GATA6 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A2 gene in gastric cancer condition [9]

TF Protein Name

 Transcription factor GATA-6 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor GATA-6 (GATA6) has been reported to activate the transcription of SLC9A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.

      Class2.3: C2H2 zinc finger factors

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        EGR1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in erythroleukemia condition [10]

TF Protein Name

 Early growth response protein 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Early growth response protein 1 (EGR1) has been reported to bind to the transcription of SLC9A2 gene in erythroleukemia condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        KLF5 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A2 gene in gastric cancer condition [9]

TF Protein Name

 Krueppel-like factor 5 Transcription Factor Info

Affected Drug/Substrate

 Metformin

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Krueppel-like factor 5 (KLF5) has been reported to activate the transcription of SLC9A2 gene in gastric cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.

        SP1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

       Transcriptional Phenomenon2

 Activation of SLC9A2 gene in colon cancer condition [11]

TF Protein Name

 Transcription factor Sp1 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (C2bbe1)

Detailed Description

 Transcription factor Sp1 (SP1) has been reported to activate the transcription of SLC9A2 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.

        SP3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A2 gene in colon cancer condition [11]

TF Protein Name

 Transcription factor Sp3 Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (C2bbe1)

Detailed Description

 Transcription factor Sp3 (SP3) has been reported to activate the transcription of SLC9A2 gene in colon cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.

        ZNF217 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in breast cancer condition [12]

TF Protein Name

 Zinc finger protein 217 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Zinc finger protein 217 (ZNF217) has been reported to bind to the transcription of SLC9A2 gene in breast cancer condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        ZNF263 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Direct binding to SLC9A2 gene [2]

TF Protein Name

 Zinc finger protein 263 Transcription Factor Info

Tissue

 Bone marrow; Kidney

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Zinc finger protein 263 (ZNF263) can directly bind to the SLC9A2 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 2.

TF Superclass3: Helix-turn-helix domains

      Class3.1: Homeo domain factors

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        CDX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition [3]

TF Protein Name

 Homeobox protein CDX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein CDX-2 (CDX2) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        NANOG 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition [13]

TF Protein Name

 Homeobox protein NANOG Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Homeobox protein NANOG (NANOG) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in prostate carcinoma condition [14]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLC9A2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

      Class3.5: Tryptophan cluster factors

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        SPI1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in K562 cells [15]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor PU.1 (SPI1) has been reported to bind to the transcription of SLC9A2 gene in K562 cells, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

       Transcriptional Phenomenon2

 Direct binding to SLC9A2 gene [16]

TF Protein Name

 Transcription factor PU.1 Transcription Factor Info

Tissue

 Adrenal gland; Blood; Bone marrow; Brain; Breast; Embryo; Foreskin; Heart; Intestine; Kidney; Lung; Muscle; Penis; Placenta; Renal cortex; Renal pelvis; Skin; Spinal cord; Stomach; Testes; Umbilical cord blood

Related DT Changes

 Direct regulating

Experiment method

 TF-transporter regulations were collected from ChIP-Seq datasets.

Detailed Description

 Transcription factor PU.1 (SPI1) can directly bind to the SLC9A2 gene, which in turn affects the expression or function of the drug transporter Sodium/hydrogen exchanger 2.

TF Superclass4: Other all-alpha-helical DNA-binding domains

      Class4.1: High-mobility group domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        SOX2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in HESC condition [13]

TF Protein Name

 Transcription factor SOX-2 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor SOX-2 (SOX2) has been reported to bind to the transcription of SLC9A2 gene in HESC condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

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        NFKB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition [3]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLC9A2 gene in health condition [3]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Transcription factor p65 (RELA) has been reported to bind to the transcription of SLC9A2 gene in health condition, which leads to an affected expression of the drug transporter Sodium/hydrogen exchanger 2.

TF Superclass7: beta-Hairpin exposed by an alpha/beta-scaffold

      Class7.1: SMAD/NF-1 DNA-binding domain factors

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        SMAD4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLC9A2 gene in epithelial ovarian cancer condition [17]

TF Protein Name

 Mothers against decapentaplegic homolog 4 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Mothers against decapentaplegic homolog 4 (SMAD4) has been reported to activate the transcription of SLC9A2 gene in epithelial ovarian cancer condition, which leads to an increased expression of the drug transporter Sodium/hydrogen exchanger 2.
References
1 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(D1):D991-5.
2 hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets. Genomics Proteomics Bioinformatics. 2020 Apr;18(2):120-228. (ID:ENSG00000115616)
3 The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. Am J Physiol Gastrointest Liver Physiol. 2001;280(4):G763-73.
4 Closure of the NCBI SRA and implications for the long-term future of genomics data storage. Genome Biol. 2011;12(3):402.
5 Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol. 2008;28(8):2732-44.
6 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
7 Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 2011;12:36.
8 Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy. Mol Cell. 2009;36(4):667-81.
9 Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. 2015;64(5):707-19.
10 Global analysis of in vivo EGR1-binding sites in erythroleukemia cell using chromatin immunoprecipitation and massively parallel sequencing. Electrophoresis. 2010;31(17):2936-43.
11 Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. Biochem J. 2007 Oct 1;407(1):101-11.
12 Global analysis of ZNF217 chromatin occupancy in the breast cancer cell genome reveals an association with ERalpha. BMC Genomics. 2014;15(1):520.
13 Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122(6):947-56.
14 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
15 Role of transcriptional corepressor ETO2 in erythroid cells. Exp Hematol. 2013;41(3):303-15.e1.
16 The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 2018 Jan 4;46(D1):D794-D801
17 ChIP-seq defined genome-wide map of TGF/SMAD4 targets: implications with clinical outcome of ovarian cancer. PLoS One. 2011;6(7):e22606.

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