Drug Transporter (DT) Information

General Information of DT
DT ID DTD0482
Gene Name SLC9A2
Protein Name Sodium/hydrogen exchanger 2
Gene ID
6549
UniProt ID
Q9UBY0
TCDB ID
2.A.36.1.17
3D Structure

Modelled DT Structure

Method: multi-sequence alignment based machine learning

Detail: Structure Info

Synonyms NHE-2; NHE2; Na(+)/H(+) exchanger 2; SLC9A2; Solute carrier family 9 member 2
DT Family Monovalent Cation:Proton Antiporter-1 (CPA1) family ;
Tissue Specificity Expressed in skeletal muscle, colon andkidney. Lower levels in the testis, prostate, ovary, and smallintestine.
Function This transporter mediates and participates in regulating pH value to eliminate acids generated by active metabolism or to combat adverse environmental conditions.
Endogenous Substrate(s) Na+; H+
Variability Data of This Drug Transporter (DT)

Regulatory Variability Data of This DT (VARIDT 4.0)

(α) Tissue Distribution Level of Sodium/hydrogen exchanger 2
Tissue Distribution Level (TD)

(β) Cell Distribution Level of Sodium/hydrogen exchanger 2
Cell Distribution Level (CD)

(γ) Organelle Distribution Level of Sodium/hydrogen exchanger 2
Organelle Distribution Level (Subc)

Regulatory Variability Data of This DT

(α) Microbiota Influence of Sodium/hydrogen exchanger 2
Microbiota Influence (MBI)

(β) Post-translational Modification of Sodium/hydrogen exchanger 2
Post-translational Modification (PTM)

(γ) Transcriptional Regulation of Sodium/hydrogen exchanger 2
Transcriptional Regulation (TSR)

(δ) Epigenetic Regulation of Sodium/hydrogen exchanger 2
Epigenetic Regulation (EGR)

(ε) Exogenous Modulation of Sodium/hydrogen exchanger 2
Exogenous Modulation (EGM)

General Variability Data of This DT

(α) Genetic Polymorphisms of Sodium/hydrogen exchanger 2
Genetic Polymorphisms of This DT (GPD)

(β) Disease-specific Protein Abundances of Sodium/hydrogen exchanger 2
Disease-specific Protein Abundances of This DT (DPAD)

(γ) Species- and Tissue-specific DT Abundances
Species/Tissue-specific Protein Abundances of This DT (S/TPAD)

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