Detail Information of Post-Translational Modifications

General Information of Drug Transporter (DT)
DT ID	DTD0482 Transporter Info
Gene Name	SLC9A2
Transporter Name	Sodium/hydrogen exchanger 2
Gene ID	6549
UniProt ID	Q9UBY0

Post-Translational Modification of This DT
Overview ofSLC9A2 Modification Sites with Functional and Structural Information
Sequence	M E P L G N W R S L R A P L P P M L L L L L L Q V A G P V G A L A E T L L N A P R A M G T S S S P P S P A S V V A P G T T L F E E S R L P V F T L D Y P H V Q I P F E I T L W I L L A S L A K I G F H L Y H K L P T I V P E S C L L I M V G L L L G G I I F G V D E K S P P A M K T D V F F L Y L L P P I V L D A G Y F M P T R P F F E N I G T I F W Y A V V G T L W N S I G I G V S L F G I C Q I E A F G L S D I T L L Q N L L F G S L I S A V D P V A V L A V F E N I H V N E Q L Y I L V F G E S L L N D A V T V V L Y N L F K S F C Q M K T I E T I D V F A G I A N F F V V G I G G V L I G I F L G F I A A F T T R F T H N I R V I E P L F V F L Y S Y L S Y I T A E M F H L S G I M A I T A C A M T M N K Y V E E N V S Q K S Y T T I K Y F M K M L S S V S E T L I F I F M G V S T V G K N H E W N W A F V C F T L A F C L M W R A L G V F V L T Q V I N R F R T I P L T F K D Q F I I A Y G G L R G A I C F A L V F L L P A A V F P R K K L F I T A A I V V I F F T V F I L G I T I R P L V E F L D V K R S N K K Q Q A V S E E I Y C R L F D H V K T G I E D V C G H W G H N F W R D K F K K F D D K Y L R K L L I R E N Q P K S S I V S L Y K K L E I K H A I E M A E T G M I S T V P T F A S L N D C R E E K I R K V T S S E T D E I R E L L S R N L Y Q I R Q R T L S Y N R H S L T A D T S E R Q A K E I L I R R R H S L R E S I R K D S S L N R E H R A S T S T S R Y L S L P K N T K L P E K L Q K R R T I S I A D G N S S D S D A D A G T T V L N L Q P R A R R F L P E Q F S K K S P Q S Y K M E W K N E V D V D S G R D M P S T P P T P H S R E K G T Q T S G L L Q Q P L L S K D Q S G S E R E D S L T E G I P P K P P P R L V W R A S E P G S R K A R F G S E K P
PTM type	X-Acetylation X-N-glycosylation X-Oxidation X-Phosphorylation X-S-palmitoylation X-Ubiquitination X: Amino Acid

Acetylation
Lysine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[1]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	679
Experimental Method	Co-Immunoprecipitation
Detailed Description	Acetylation at SLC9A2 Lysine 679 has the potential to affect its expression or activity.
N-glycosylation
Asparagine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[2]
Role of PTM	Potential impacts
Modified Residue	Asparagine	Modified Location	350
Experimental Method	Co-Immunoprecipitation
Detailed Description	N-linked Glycosylation at SLC9A2 Asparagine 350 has the potential to affect its expression or activity.
Oxidation
Cystine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[3]
Role of PTM	Potential impacts
Modified Residue	Cystine	Modified Location	518
Experimental Method	Co-Immunoprecipitation
Detailed Description	Oxidation at SLC9A2 Cystine 518 has the potential to affect its expression or activity.
Phosphorylation
Serine	26 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	46
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 46 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A2			[4]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	47
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 47 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	550
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 550 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	551
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 551 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	581
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 581 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A2			[6], [7]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	595
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 595 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC9A2			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	596
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 596 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC9A2			[8]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	606
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 606 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	623
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 623 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	647
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 647 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC9A2			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	661
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 661 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC9A2			[9]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	663
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 663 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC9A2			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	665
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 665 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC9A2			[8], [11]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	669
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 669 has the potential to affect its expression or activity.
PTM Phenomenon15	Have the potential to influence SLC9A2			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	687
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 687 has the potential to affect its expression or activity.
PTM Phenomenon16	Have the potential to influence SLC9A2			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	693
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 693 has the potential to affect its expression or activity.
PTM Phenomenon17	Have the potential to influence SLC9A2			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	694
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 694 has the potential to affect its expression or activity.
PTM Phenomenon18	Have the potential to influence SLC9A2			[13], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	696
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 696 has the potential to affect its expression or activity.
PTM Phenomenon19	Have the potential to influence SLC9A2			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	720
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 720 has the potential to affect its expression or activity.
PTM Phenomenon20	Have the potential to influence SLC9A2			[15]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	739
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 739 has the potential to affect its expression or activity.
PTM Phenomenon21	Have the potential to influence SLC9A2			[12], [14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	745
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 745 has the potential to affect its expression or activity.
PTM Phenomenon22	Have the potential to influence SLC9A2			[15], [16]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	752
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 752 has the potential to affect its expression or activity.
PTM Phenomenon23	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	760
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 760 has the potential to affect its expression or activity.
PTM Phenomenon24	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	769
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 769 has the potential to affect its expression or activity.
PTM Phenomenon25	Have the potential to influence SLC9A2			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	780
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 780 has the potential to affect its expression or activity.
PTM Phenomenon26	Have the potential to influence SLC9A2			[14]
Role of PTM	Potential impacts
Modified Residue	Serine	Modified Location	798
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Serine 798 has the potential to affect its expression or activity.
Threonine	14 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	45
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 45 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A2			[4]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	342
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 342 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	578
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 578 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A2			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	594
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 594 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A2			[5], [6]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	598
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 598 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A2			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	662
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 662 has the potential to affect its expression or activity.
PTM Phenomenon7	Have the potential to influence SLC9A2			[9]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	664
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 664 has the potential to affect its expression or activity.
PTM Phenomenon8	Have the potential to influence SLC9A2			[9], [10]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	674
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 674 has the potential to affect its expression or activity.
PTM Phenomenon9	Have the potential to influence SLC9A2			[12], [13]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	685
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 685 has the potential to affect its expression or activity.
PTM Phenomenon10	Have the potential to influence SLC9A2			[12], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	746
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 746 has the potential to affect its expression or activity.
PTM Phenomenon11	Have the potential to influence SLC9A2			[12], [14]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	749
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 749 has the potential to affect its expression or activity.
PTM Phenomenon12	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	757
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 757 has the potential to affect its expression or activity.
PTM Phenomenon13	Have the potential to influence SLC9A2			[5]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	759
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 759 has the potential to affect its expression or activity.
PTM Phenomenon14	Have the potential to influence SLC9A2			[17], [18]
Role of PTM	Potential impacts
Modified Residue	Threonine	Modified Location	782
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Threonine 782 has the potential to affect its expression or activity.
Tyrosine	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[11], [19]
Role of PTM	Potential impacts
Modified Residue	Tyrosine	Modified Location	667
Experimental Method	Co-Immunoprecipitation
Detailed Description	Phosphorylation at SLC9A2 Tyrosine 667 has the potential to affect its expression or activity.
S-palmitoylation
Unclear Residue	1 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	.			[20]
Role of PTM	Protein Activity Modulation
Experimental Material(s)	kidney tissues
Experimental Method	Co-Immunoprecipitation
Detailed Description	S-palmitoylation at SLC9A2 has been reported to play a critical role in kidney clear cell carcinoma (KIRC), and targeting this modification may offer a novel therapeutic strategy.
Ubiquitination
Lysine	6 PTM Phenomena Related to This Residue		Click to Show/Hide the Full List
PTM Phenomenon1	Have the potential to influence SLC9A2			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	360
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 360 has the potential to affect its expression or activity.
PTM Phenomenon2	Have the potential to influence SLC9A2			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	364
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 364 has the potential to affect its expression or activity.
PTM Phenomenon3	Have the potential to influence SLC9A2			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	531
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 531 has the potential to affect its expression or activity.
PTM Phenomenon4	Have the potential to influence SLC9A2			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	532
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 532 has the potential to affect its expression or activity.
PTM Phenomenon5	Have the potential to influence SLC9A2			[21], [22]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	536
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 536 has the potential to affect its expression or activity.
PTM Phenomenon6	Have the potential to influence SLC9A2			[21]
Role of PTM	Potential impacts
Modified Residue	Lysine	Modified Location	540
Experimental Method	Co-Immunoprecipitation
Detailed Description	Ubiquitination at SLC9A2 Lysine 540 has the potential to affect its expression or activity.

References
1	Primary psychosomatic treatment. Z Arztl Fortbild (Jena). 1994 Sep;88(9):655-7.
2	dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications. Nucleic Acids Res. 2022 Jan 7;50(D1):D471-D479. (ID: SL9A2_HUMAN)
3	A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 Mar 5;180(5):968-983.e24.
4	Quantitative phosphoproteomics of Alzheimer's disease reveals cross-talk between kinases and small heat shock proteins. Proteomics. 2015 Jan;15(2-3):508-519.
5	Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res. 2013 Jun 7;12(6):2414-21.
6	Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis. Sci Rep. 2018 Feb 2;8(1):2269.
7	Phosphoproteomic analysis of the highly-metastatic hepatocellular carcinoma cell line, MHCC97-H. Int J Mol Sci. 2015 Feb 16;16(2):4209-25.
8	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul;13(7):1690-704.
9	An integrated strategy for highly sensitive phosphoproteome analysis from low micrograms of protein samples. Analyst. 2018 Jul 23;143(15):3693-3701.
10	Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS/MS proteomics and phosphoproteomics. Anal Bioanal Chem. 2017 Jul;409(19):4615-4625.
11	Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma. Mol Cell Proteomics. 2014 Apr;13(4):1034-49.
12	Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 Jun 2;534(7605):55-62.
13	Quantitative phosphoproteomic analysis identifies novel functional pathways of tumor suppressor DLC1 in estrogen receptor positive breast cancer. PLoS One. 2018 Oct 2;13(10):e0204658.
14	Proteogenomic integration reveals therapeutic targets in breast cancer xenografts. Nat Commun. 2017 Mar 28;8:14864.
15	TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells. J Proteome Res. 2013 Sep 6;12(9):4136-51.
16	Quantitative phosphoproteomics identifies substrates and functional modules of Aurora and Polo-like kinase activities in mitotic cells. Sci Signal. 2011 Jun 28;4(179):rs5.
17	Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line. Anal Chem. 2019 Feb 5;91(3):2201-2208.
18	Phosphoproteins in extracellular vesicles as candidate markers for breast cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3175-3180.
19	Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71.
20	zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. J Cancer Res Clin Oncol. 2024;150(4):194. Published 2024 Apr 15.
21	Systematic functional prioritization of protein posttranslational modifications. Cell. 2012 Jul 20;150(2):413-25.
22	A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284.

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Detail Information of Post-Translational Modifications

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