Detail Information of Transcriptional Regulations

General Information of Drug Transporter (DT)
DT ID DTD0029 Transporter Info
Gene Name SLCO1A2
Transporter Name Organic anion transporting polypeptide 1A2
Gene ID
6579
UniProt ID
P46721

Transcriptional Regulation of This DT (TSR)

TF Superclass1: Basic domains

      Class1.1: Basic leucine zipper factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        BACH1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1A2 gene in breast cancer bone metastasis condition [1]

TF Protein Name

 Transcription regulator protein BACH1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription regulator protein BACH1 (BACH1) has been reported to activate the transcription of SLCO1A2 gene in breast cancer bone metastasis condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1A2.

      Class1.2: Basic helix-loop-helix factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        TCF4 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1A2 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Transcription factor 4 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Up regulating

Detailed Description

 Transcription factor 4 (TCF4) has been reported to activate the transcription of SLCO1A2 gene in glioblastoma multiforme condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1A2.

TF Superclass2: Zinc-coordinating DNA-binding domains

      Class2.1: Nuclear receptors with C4 zinc fingers

Click to Show/Hide the Full List of 4 TF(s) Regulating This DT

        AR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in prostate cancer condition [3]

TF Protein Name

 Androgen receptor Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Androgen receptor (AR) has been reported to bind to the transcription of SLCO1A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

        HNF4A 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 4-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 4-alpha (HNF4A) has been reported to bind to the transcription of SLCO1A2 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

        NR1I2 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1A2 gene in breast cancer condition [5]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Up regulating

Experimental Material

 human breast cancer cell isolates

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2) has been reported to activate the transcription of SLCO1A2 gene in breast cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1A2.

       Transcriptional Phenomenon2

 Activation of SLCO1A2 gene in health condition [6]

TF Protein Name

 Nuclear receptor subfamily 1 group I member 2 Transcription Factor Info

Studied Phenotype

 Heallth [ICD11: N.A]

Tissue

 Liver

Related DT Changes

 up regulating

Experimental Material

 Human liver samples

Detailed Description

 Nuclear receptor subfamily 1 group I member 2 (NR1I2), influenced by the metabolite from Host unspecified microbiota, has been reported to activate the transcription of SLCO1A2 gene in health condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1A2.

        VDR 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Activation of SLCO1A2 gene in colon cancer condition [7]

TF Protein Name

 Vitamin D3 receptor Transcription Factor Info

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Tissue

 Colon

Related DT Changes

 Up regulating

Experimental Material

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 Vitamin D3 receptor (VDR) has been reported to activate the transcription of SLCO1A2 gene in colon cancer condition, which leads to an increased expression of the drug transporter Organic anion transporting polypeptide 1A2.

TF Superclass3: Helix-turn-helix domains

      Class3.3: Fork head / winged helix factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        FOXA1 

Click to Show/Hide to Show 2 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in prostate carcinoma condition [8]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLCO1A2 gene in prostate carcinoma condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

       Transcriptional Phenomenon2

 Binding to SLCO1A2 gene in prostate cancer condition [9]

TF Protein Name

 Hepatocyte nuclear factor 3-alpha Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-alpha (FOXA1) has been reported to bind to the transcription of SLCO1A2 gene in prostate cancer condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

        FOXA2 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in health condition [4]

TF Protein Name

 Hepatocyte nuclear factor 3-beta Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Hepatocyte nuclear factor 3-beta (FOXA2) has been reported to bind to the transcription of SLCO1A2 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

TF Superclass6: Immunoglobulin fold

      Class6.1: Rel homology region factors

Click to Show/Hide the Full List of 2 TF(s) Regulating This DT

        NFKB1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO1A2 gene in breast cancer condition [10]

TF Protein Name

 Nuclear factor NF-kappa-B p105 subunit Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Down regulating

Experimental Material

 Human invasive breast carcinoma of no special type cells (MCF-7)

Detailed Description

 Nuclear factor NF-kappa-B p105 subunit (NFKB1) has been reported to repress the transcription of SLCO1A2 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 1A2.

        RELA 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Repression of SLCO1A2 gene in breast cancer condition [10]

TF Protein Name

 Transcription factor p65 Transcription Factor Info

Studied Phenotype

 Breast cancer [ICD11: 2C60-2C6Z]

Tissue

 Breast

Related DT Changes

 Down regulating

Experimental Material

 Human invasive breast carcinoma of no special type cells (MCF-7)

Detailed Description

 Transcription factor p65 (RELA) has been reported to repress the transcription of SLCO1A2 gene in breast cancer condition, which leads to a decreased expression of the drug transporter Organic anion transporting polypeptide 1A2.

      Class6.2: STAT domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        STAT3 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in glioblastoma multiforme condition [2]

TF Protein Name

 Signal transducer and activator of transcription 3 Transcription Factor Info

Affected Drug/Substrate

 Temozolomide

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Signal transducer and activator of transcription 3 (STAT3) has been reported to bind to the transcription of SLCO1A2 gene in glioblastoma multiforme condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.

      Class6.4: Runt domain factors

Click to Show/Hide the Full List of 1 TF(s) Regulating This DT

        RUNX1 

Click to Show/Hide to Show 1 Transcriptional Phenomena      

       Transcriptional Phenomenon1

 Binding to SLCO1A2 gene in health condition [11]

TF Protein Name

 Runt-related transcription factor 1 Transcription Factor Info

Studied Phenotype

 .

Related DT Changes

 Direct regulating

Detailed Description

 Runt-related transcription factor 1 (RUNX1) has been reported to bind to the transcription of SLCO1A2 gene in health condition, which leads to an affected expression of the drug transporter Organic anion transporting polypeptide 1A2.
References
1 Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis. J Biol Chem. 2012;287(40):33533-44.
2 Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma. Neuro Oncol. 2013;15(3):279-89.
3 Inhibition of p53 expression modifies the specificity of chromatin binding by the androgen receptor. Oncotarget. 2012;3(2):183-94.
4 Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing. Nucleic Acids Res. 2009;37(22):7498-508.
5 Interplay between the nuclear receptor pregnane X receptor and the uptake transporter organic anion transporter polypeptide 1A2 selectively enhances estrogen effects in breast cancer. Cancer Res. 2008 Nov 15;68(22):9338-47.
6 Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
7 The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor. Mol Pharmacol. 2012 Jul;82(1):37-46.
8 SUMO ligase PIAS1 functions as a target gene selective androgen receptor coregulator on prostate cancer cell chromatin. Nucleic Acids Res. 2015;43(2):848-61.
9 Integrative analysis of FOXP1 function reveals a tumor-suppressive effect in prostate cancer. Mol Endocrinol. 2014;28(12):2012-24.
10 Identification of a NF Kappa B Inhibition Site on the Proximal Promoter Region of Human Organic Anion Transporting Polypeptide 1A2 Coding Gene SLCO1A2. Drug Metab Dispos. 2018 May;46(5):643-651.
11 Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family. Genes Dev. 2007;21(15):1882-94.

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