Detail Information of Mutation-induced Spatial Variation

General Information of Drug Transporter (DT)
DT ID DTD0547 Transporter Info
Gene Name KCNK4
Transporter Name Potassium channel subfamily K member 4
Gene ID
50801
UniProt ID
Q9NYG8
Mutation-induced Structural Variation (MSV) of This DT
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 		PDB ID
7LJB
Expression System Komagataella pastoris; Mus musculus
Method X-ray
Resolution 2.97 Å
Corresponding chain A/B
Mutation Site(s) N104Q; N108Q; G158D [1]
Structure Details
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Modeling Method X-ray
Publication year 2021
Closely Related Crystal Structure of This MSV
PDB ID Scanning Method Resolution Mutation Sites Details Ref
7LJA X-ray 2.77 Å N104Q; N108Q; A198E
Show Detail
[1]
Structure
Expression System Komagataella pastoris; Mus musculus
Corresponding chain A/B
Sequence Length 1-264 Mutation Yes
7LJ4 X-ray 2.782 Å N104Q; N108Q; A270P
Show Detail
[1]
Structure
Expression System Komagataella pastoris; Mus musculus
Corresponding chain A/B
Sequence Length 1-264 Mutation Yes
7LJ5 X-ray 2.26 Å N104Q; N108Q; G158D
Show Detail
[1]
Structure
Expression System Komagataella pastoris; Mus musculus
Corresponding chain A/B
Sequence Length 1-264 Mutation Yes
7LJB X-ray 2.97 Å N104Q; N108Q; G158D
Show Detail
[1]
Structure
Expression System Komagataella pastoris; Mus musculus
Corresponding chain A/B
Sequence Length 1-264 Mutation Yes
References
1 Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021;109(18):2902-2913.e4.

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