Detail Information of Mutation-induced Spatial Variation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0547 Transporter Info | ||||
| Gene Name | KCNK4 | ||||
| Transporter Name | Potassium channel subfamily K member 4 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Mutation-induced Structural Variation (MSV) of This DT | |||||
| PDB ID | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Method | X-ray | ||||
| Resolution | 2.77 Å | ||||
| Corresponding chain | A/B | ||||
| Mutation Site(s) | N104Q; N108Q; A198E | [1] | |||
| Structure Details | |||||
| Modeling Method | X-ray | ||||
| Publication year | 2021 | ||||
| PDB ID | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Method | X-ray | ||||
| Resolution | 2.782 Å | ||||
| Corresponding chain | A/B | ||||
| Mutation Site(s) | N104Q; N108Q; A270P | [1] | |||
| Structure Details | |||||
| Modeling Method | X-ray | ||||
| Publication year | 2021 | ||||
| PDB ID | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Method | X-ray | ||||
| Resolution | 2.26 Å | ||||
| Corresponding chain | A/B | ||||
| Mutation Site(s) | N104Q; N108Q; G158D | [1] | |||
| Structure Details | |||||
| Modeling Method | X-ray | ||||
| Publication year | 2021 | ||||
| PDB ID | Scanning Method | Resolution | Mutation Sites | Details | Ref |
| 7LJA | X-ray | 2.77 Å | N104Q; N108Q; A198E | [1] | |
| Structure | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Corresponding chain | A/B | ||||
| Sequence Length | 1-264 | Mutation | Yes | ||
| 7LJ4 | X-ray | 2.782 Å | N104Q; N108Q; A270P | [1] | |
| Structure | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Corresponding chain | A/B | ||||
| Sequence Length | 1-264 | Mutation | Yes | ||
| 7LJ5 | X-ray | 2.26 Å | N104Q; N108Q; G158D | [1] | |
| Structure | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Corresponding chain | A/B | ||||
| Sequence Length | 1-264 | Mutation | Yes | ||
| 7LJB | X-ray | 2.97 Å | N104Q; N108Q; G158D | [1] | |
| Structure | |||||
| Expression System | Komagataella pastoris; Mus musculus | ||||
| Corresponding chain | A/B | ||||
| Sequence Length | 1-264 | Mutation | Yes | ||
| References | |||||
| 1 | Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK. Neuron. 2021;109(18):2902-2913.e4. | ||||
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