Detail Information of Mutation-induced Spatial Variation

General Information of Drug Transporter (DT)
DT ID DTD0529 Transporter Info
Gene Name SCN9A
Transporter Name Voltage-gated sodium channel alpha Nav1.7
Gene ID
6335
UniProt ID
Q15858
Mutation-induced Structural Variation (MSV) of This DT
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 		PDB ID
7XVE
Expression System Homo sapiens
Method EM
Resolution 2.7 Å
Corresponding chain A
Mutation Site(s) E190K; G183R; L900F; T904M; A908F; V981F; M986F; V987F [1]
Structure Details
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Modeling Method EM
Publication year 2022
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 		PDB ID
7XVF
Expression System Homo sapiens
Method EM
Resolution 2.8 Å
Corresponding chain A
Mutation Site(s) E190K; G183R; L900F; T904M; A908F; V981F; M986F; V987F [1]
Structure Details
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Modeling Method EM
Publication year 2022
Expression System Trichoplusia ni
Method EM
Resolution 3.6 Å
Corresponding chain N.A.
Mutation Site(s) R373A; L481A; [2]
Structure Details
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Modeling Method EM
Publication year 2020
Closely Related Crystal Structure of This MSV
PDB ID Scanning Method Resolution Mutation Sites Details Ref
7XVE EM 2.7 Å E190K; G183R; L900F; T904M; A908F; V981F; M986F; V987F
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[1]
Structure
Expression System Homo sapiens
Corresponding chain A
Sequence Length 1-1988 Mutation Yes
7XVF EM 2.8 Å E190K; G183R; L900F; T904M; A908F; V981F; M986F; V987F
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[1]
Structure
Expression System Homo sapiens
Corresponding chain A
Sequence Length 1-1989 Mutation Yes
7K48 EM 3.6 Å R373A; L481A;
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[2]
Structure
Expression System Trichoplusia ni
Corresponding chain .
Sequence Length . Mutation Yes
8XMN EM 3.37 Å L909F; G1497C
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[3]
Structure
Expression System Homo sapiens
Corresponding chain A
Sequence Length 1-1988 Mutation Yes
8XMO EM 3.39 Å N.A.
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[3]
Structure
Expression System Homo sapiens
Corresponding chain A
Sequence Length 1-1988 Mutation Yes
8XMM EM 2.89 Å L909F; T913M; A917F; V1481I; V1482F; G1497C
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[3]
Structure
Expression System Homo sapiens
Corresponding chain A
Sequence Length 1-1988 Mutation Yes
References
1 Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7. Proc Natl Acad Sci U S A. 2022;119(33):e2209164119.
2 Structural Basis for High-Affinity Trapping of the Na(V)1.7 Channel in Its Resting State by Tarantula Toxin. Mol Cell. 2021 Jan 7;81(1):38-48.e4.
3 Dissection of the structure-function relationship of Na(v) channels. Proc Natl Acad Sci U S A. 2024;121(9):e2322899121.

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