Detail Information of Microbiota Influence

General Information of Drug Transporter (DT)
DT ID DTD0021 Transporter Info
Gene Name SLC15A1
Transporter Name Peptide transporter 1
Gene ID
6564
UniProt ID
P46059
Microbiota Influence of This DT (MBI)

Bacteria: Bacillota

   Genus: Geobacillus

     Geobacillus kaustophilus 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [1], [2]

Regulating Factor
GK2020

Detailed Description

 The protein gk2020 of Geobacillus kaustophilus has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Staphylococcus

     Staphylococcus hominis 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [3]

Regulating Factor
PepTSh

Detailed Description

 The protein PepTSh of Staphylococcus hominis SK119 has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Streptococcus

     Streptococcus thermophilus 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [1], [4]

Regulating Factor
PepTSt

Detailed Description

 The protein PepTSt of Streptococcus thermophilus LMG 18311 has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Pseudomonadota

   Genus: Escherichia

     Escherichia coli 

Microbe Info

Click to Show/Hide the Full List 10 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
ompC

Detailed Description

 The protein ompc of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC15A1 substrates/drugs in the health condition [6]

Regulating Factor
ompC

Detailed Description

 The protein ompC of Escherichia coli JM712 has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence3

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
ompF

Detailed Description

 The protein ompf of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence4

 Co-transport of human SLC15A1 substrates/drugs in the health condition [6]

Regulating Factor
ompF

Detailed Description

 The protein ompF of Escherichia coli JM712 has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence5

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
ybgH

Detailed Description

 The protein ybgh of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence6

 Co-transport of human SLC15A1 substrates/drugs in the health condition [7], [8]

Regulating Factor
ydgR

Detailed Description

 The protein ydgR of Escherichia coli BL21 has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence7

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
ydgR

Detailed Description

 The protein ydgr of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence8

 Co-transport of human SLC15A1 substrates/drugs in the health condition [9]

Regulating Factor
ydgR

Detailed Description

 The protein ydgr of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence9

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
yhiP

Detailed Description

 The protein yhip of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence10

 Co-transport of human SLC15A1 substrates/drugs in the health condition [5]

Regulating Factor
yjdL

Detailed Description

 The protein yjdl of Escherichia coli has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Shewanella

     Shewanella oneidensis 

Microbe Info

Click to Show/Hide the Full List 2 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [1], [10]

Regulating Factor
PepTSo

Detailed Description

 The protein peptso of Shewanella oneidensis has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

       Microbe Influence2

 Co-transport of human SLC15A1 substrates/drugs in the health condition [1], [11], [12]

Regulating Factor
PepTSo2

Detailed Description

 The protein peptso2 of Shewanella oneidensis has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

   Genus: Yersinia

     Yersinia enterocolitica 

Microbe Info

Click to Show/Hide the Full List 1 Microbe Influence Related to This Species      

       Microbe Influence1

 Co-transport of human SLC15A1 substrates/drugs in the health condition [1], [13]

Regulating Factor
YePEPT

Detailed Description

 The protein yepept of Yersinia enterocolitica has been reported to transport similar substrates/drugs of SLC15A1, which affects the distribution of its substrate/drug in vivo.

Bacteria: Host unspecified microbiota

   Genus: Unknown microbiota

     Host unspecified microbiota 

Click to Show/Hide the Full List 6 Microbe Influence Related to This Species      

       Microbe Influence1

 Up regulating of SLC15A1 expression in colon cancer condition [14]

Regulating Factor
Chenodeoxycholic acid

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Studied Tissue

 Colon

In Vitro Model

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 The metabolite chenodeoxycholic acid generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC15A1.

       Microbe Influence2

 Up regulating of SLC15A1 expression in colon cancer condition [14]

Regulating Factor
Deoxycholic acid

Studied Phenotype

 Colon cancer [ICD11: 2B90]

Studied Tissue

 Colon

In Vitro Model

 Human colon adenocarcinoma cells (Caco-2)

Detailed Description

 The metabolite deoxycholic acid generated from the host unspecified microbiota has been reported to increase the expression of the drug transporter SLC15A1.

       Microbe Influence3

 Down regulating of SLC15A1 expression in conventional mice compared with germ-free mice [15]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Jejunum

In Vivo Model

 C57BL/6 germ-free/conventionally-raised mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC15A1.

       Microbe Influence4

 Down regulating of SLC15A1 expression in conventional mice compared with germ-free mice [16], [17]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Small intestine

In Vivo Model

 C57BL/6N mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC15A1.

       Microbe Influence5

 Down regulating of SLC15A1 expression in hypoxia condition [18]

Studied Phenotype

 Hypoxia [ICD11: MD11.1]

Studied Tissue

 Liver

In Vivo Model

 Sprague-Dawley rats

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC15A1.

       Microbe Influence6

 Down regulating of SLC15A1 expression in conventional mice compared with germ-free mice [19]

Studied Phenotype

 Conventional mice compared with germ-free mice [ICD11: N.A]

Studied Tissue

 Large intestine

In Vivo Model

 C57BL/6 mice

Detailed Description

 The host unspecified microbiota has been reported to decrease the expression of the drug transporter SLC15A1.
References
1 Role of electrostatic interactions for ligand recognition and specificity of peptide transporters. BMC Biol. 2015 Aug 6;13:58.
2 Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11343-8.
3 Structural basis of malodour precursor transport in the human axilla. Elife. 2018 Jul 3;7:e34995.
4 Alternating access mechanism in the POT family of oligopeptide transporters. EMBO J. 2012 Aug 15;31(16):3411-21.
5 DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli. FEBS J. 2008 Jul;275(13):3290-8.
6 The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. J Antimicrob Chemother. 1993 Aug;32(2):195-213.
7 The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells. J Biol Chem. 2018 Jan 19;293(3):1007-1017.
8 Sulpiride Serves, a Substrate for the Gut Microbiome. Dose Response. 2021 Feb 11;19(1):1559325820987943.
9 Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR. Res Microbiol. 2017 Jun;168(5):443-449.
10 Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2. EMBO J. 2011 Jan 19;30(2):417-26.
11 Structural insights into substrate recognition in proton-dependent oligopeptide transporters. EMBO Rep. 2013 Sep;14(9):804-10.
12 Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2. Nat Struct Mol Biol. 2014 Aug;21(8):728-31.
13 Engineering and functional characterization of a proton-driven beta-lactam antibiotic translocation module for bionanotechnological applications. Sci Rep. 2021 Aug 26;11(1):17205.
14 Gut Microbiota-Mediated Bile Acid Transformations Alter the Cellular Response to Multidrug Resistant Transporter Substrates in Vitro: Focus on P-glycoprotein. Mol Pharm. 2018 Dec 3;15(12):5711-5727.
15 Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice. BMC Genomics. 2018 Nov 21;19(1):834.
16 New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium. Clin Pharmacol Ther. 2022 Sep;112(3):540-561.
17 Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes. Drug Metab Pharmacokinet. 2019 Apr;34(2):159-162.
18 Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia. Front Pharmacol. 2022 Sep 15;13:977370.
19 RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice. Drug Metab Dispos. 2017 Dec;45(12):1225-1238.

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