Crystal Structure of This DT
Crystallisation Method:EM
Corresponding Chain:A/C/E/G
Sequence Length:76-620
Detail: Struture Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0513 Transporter Info | ||||
| Gene Name | KCNQ1 | ||||
| Protein Name | Voltage-gated potassium channel Kv7.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Sus scrofa (Pig) | |||||
| Gene Name | KCNQ1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UZZ_A Sequence Length:546 Identity:93.04% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1135.723 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.06 ±0.34 Residues in Favored Region:530 Ramachandran favored:97.43% Number of Outliers:1 Ramachandran outliers:0.18% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Cavia porcellus (Guinea pig) | |||||
| Gene Name | KCNQ1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UZZ_A Sequence Length:545 Identity:95.596% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1100.984 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.25 ±0.33 Residues in Favored Region:532 Ramachandran favored:97.97% Number of Outliers:3 Ramachandran outliers:0.55% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Xenopus laevis (African clawed frog) | |||||
| Gene Name | kcnq1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5VMS_A Sequence Length:547 Identity:99.452% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1114.135 kcal/mol | |||
| Ramachandra Favored | Medium |
||||
| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.16 ±0.32 Residues in Favored Region:533 Ramachandran favored:97.80% Number of Outliers:2 Ramachandran outliers:0.37% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277. Nat Commun. 2022;13(1):3760. | ||||
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