Crystal Structure of This DT
Crystallisation Method:EM
Corresponding Chain:A/C/E/G
Sequence Length:76-620
Detail: Struture Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0513 Transporter Info | ||||
| Gene Name | KCNQ1 | ||||
| Protein Name | Voltage-gated potassium channel Kv7.1 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Mus musculus (Mouse) | |||||
| Gene Name | Kcnq1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UZZ_A Sequence Length:544 Identity:94.301% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1115.512 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.16 ±0.36 Residues in Favored Region:522 Ramachandran favored:96.31% Number of Outliers:2 Ramachandran outliers:0.37% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Rattus norvegicus (Rat) | |||||
| Gene Name | Kcnq1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UZZ_A Sequence Length:544 Identity:94.853% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1082.15 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.94 ±0.34 Residues in Favored Region:519 Ramachandran favored:95.76% Number of Outliers:2 Ramachandran outliers:0.37% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| Oryctolagus cuniculus (Rabbit) | |||||
| Gene Name | KCNQ1 | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:6UZZ_A Sequence Length:547 Identity:92.139% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -1197.318 kcal/mol | |||
| Ramachandra Favored | Excellent |
||||
| QMEANBrane Quality | Medium |
||||
| Ramachandran Plot |
Ramz Z Score:0.03 ±0.35 Residues in Favored Region:535 Ramachandran favored:98.17% Number of Outliers:2 Ramachandran outliers:0.37% |
||||
| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277. Nat Commun. 2022;13(1):3760. | ||||
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