Crystal Structure of This DT
Crystallisation Method:EM
Corresponding Chain:A
Sequence Length:1-1480
Detail: Struture Info
Detail Information of Inter-species Structural Difference
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0060 Transporter Info | ||||
| Gene Name | ABCC7 | ||||
| Protein Name | Cystic fibrosis transmembrane conductance regulator | ||||
| Gene ID | |||||
| UniProt ID | |||||
| 3D Structure |
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| Inter-species Structural Differences (ISD) | |||||
| Macaca fascicularis (Cynomolgus monkey) | |||||
| Gene Name | CFTR | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5UAK_A Sequence Length:1481 Identity:98.244% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3179.255 kcal/mol | |||
| Ramachandra Favored | Medium |
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| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-1.38 ±0.2 Residues in Favored Region:1435 Ramachandran favored:97.03% Number of Outliers:11 Ramachandran outliers:0.74% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
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| Click to Save Local Quality Plot in PNG Format | |||||
| Bos taurus (Bovine) | |||||
| Gene Name | CFTR | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5UAK_A Sequence Length:1481 Identity:90.621% |
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| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3193.346 kcal/mol | |||
| Ramachandra Favored | Medium |
||||
| QMEANBrane Quality | Medium |
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| Ramachandran Plot |
Ramz Z Score:-0.94 ±0.2 Residues in Favored Region:1437 Ramachandran favored:97.16% Number of Outliers:8 Ramachandran outliers:0.54% |
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| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| Cavia porcellus (Guinea pig) | |||||
| Gene Name | CFTR | ||||
| UniProt ID | |||||
| UniProt Entry | |||||
| 3D Structure |
Method:Homology modeling Teplate PDB:5UAK_A Sequence Length:1481 Identity:90.682% |
||||
| Click to Save PDB File in TXT Format | |||||
| Performance | Minimized Score | -3220.184 kcal/mol | |||
| Ramachandra Favored | Medium |
||||
| QMEANBrane Quality | Medium |
||||
| Ramachandran Plot |
Ramz Z Score:-0.84 ±0.2 Residues in Favored Region:1441 Ramachandran favored:97.43% Number of Outliers:6 Ramachandran outliers:0.41% |
||||
| Click to Save Ramachandran Plot in PNG Format | |||||
| Local Quality |
QMEANBrane Score:0.75 |
||||
| Click to Save Local Quality Plot in PNG Format | |||||
| References | |||||
| 1 | Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J. 2004 Jan 28;23(2):282-93. | ||||
| 2 | Side chain and backbone contributions of Phe508 to CFTR folding. Nat Struct Mol Biol. 2005 Jan;12(1):10-6. | ||||
| 3 | Requirements for efficient correction of F508 CFTR revealed by analyses of evolved sequences. Cell. 2012 Jan 20;148(1-2):164-74. | ||||
| 4 | Conformational Changes of CFTR upon Phosphorylation and ATP Binding. Cell. 2017 Jul 27;170(3):483-491.e8. | ||||
| 5 | Cystic fibrosis transmembrane conductance regulator: solution structures of peptides based on the Phe508 region, the most common site of disease-causing DeltaF508 mutation. Biochemistry. 1999 Jun 8;38(23):7453-61. | ||||
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